A5060843939- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Eosinophilic Disorders and Syndromes
- Food Allergy and Anaphylaxis Research
- Immunodeficiency and Autoimmune Disorders
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Child and Adolescent Psychosocial and Emotional Development
- Digital Mental Health Interventions
- Eosinophilic Esophagitis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Mobile Health and mHealth Applications
- Respiratory and Cough-Related Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood groups and transfusion
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Adenosine and Purinergic Signaling
- Animal Virus Infections Studies
- Cardiac Imaging and Diagnostics
- Restraint-Related Deaths
- Bacterial Infections and Vaccines
- Antimicrobial Resistance in Staphylococcus
- Multiple Myeloma Research and Treatments
- Perfectionism, Procrastination, Anxiety Studies
University of Kansas
2015-2024
University of Kansas Medical Center
2012-2022
Kansas City Public Schools
2016-2021
ENT and Allergy
2019
University Medical Center
2018
German Primate Center
2014
Current treatments for long-term prophylaxis in hereditary angioedema have limitations.To assess the efficacy of lanadelumab, a fully human monoclonal antibody that selectively inhibits active plasma kallikrein, preventing attacks.Phase 3, randomized, double-blind, parallel-group, placebo-controlled trial conducted at 41 sites Canada, Europe, Jordan, and United States. Patients were randomized between March 2016, September 9, 2016; last day follow-up was April 13, 2017. Randomization 2:1...
Objective: Describe the clinical characteristics and histopathology findings in a family with two siblings affected deficiency of adenosine deaminase 2 (DADA2). Both patients presented childhood polyarthritis developed significant neurological gastrointestinal features DADA2 early-adulthood, including variable degrees immunologic hematologic manifestations. Methods: CECR1 exon sequencing serum (ADA2) levels were performed to confirm diagnosis DADA2. Comparison ADA2 made patients, carriers...
Middle East respiratory syndrome coronavirus (MERS-CoV) infection is associated with a high case-fatality rate, and the potential pandemic spread of virus public health concern. The spike protein MERS-CoV (MERS-S) facilitates viral entry into host cells, which depends on activation MERS-S by cellular proteases. Proteolytic during uptake target cells has been demonstrated. However, it unclear whether also cleaved S synthesis in infected cleavage required for infectivity. Here, we show that...
Introduction Asthma is a leading cause of youth morbidity in the USA, affecting >8% youth. Adherence to inhaled corticosteroids (ICS) can prevent asthma-related morbidity; however, typical adolescent with asthma takes fewer than 50% their prescribed doses. Adolescents are uniquely vulnerable suboptimal self-management due still-developing executive functioning capabilities that may impede consistent self-regulation and weaken attempts use problem solving overcome barriers ICS adherence....
Adolescents diagnosed with persistent asthma commonly take less than 50% of their prescribed inhaled corticosteroids (ICS), placing them at risk for asthma-related morbidity. Adolescents' difficulties adherence occur in the context normative developmental changes (eg, increased responsibility disease management) and rely upon still developing self-regulation problem-solving skills that are integral self-management. We developed an adaptive mobile health system, Responsive Asthma Care Teens...
Mast cells are important of the immune system. Although, traditionally considered as key players in allergic and hypersensitivity reactions emerging evidence suggest that mast have many complex roles vascular disease. These include regulation vasodilation, angiogenesis, activation matrix metalloproteinases, apoptosis smooth muscle cells, renin angiotensin also known to play an immunomodulatory role via modulation regulatory T-cell (T-reg), macrophage endothelial cell functions. This dual is...
A 48-year-old man with typical features of Schnitzler Syndrome is presented, followed by a discussion the pathogenesis and clinical aspects this rare disease. Some challenges we others have faced in diagnosing treating disease are also discussed. Clinical pearls pitfalls emphasized to aid clinicians from varying specialties recognizing syndrome providing appropriate therapy. associated high morbidity increased risk lymphoproliferative disorders. Accurate diagnosis vital restoring quality...
Background: As desensitization protocols become more readily available and published, institutions are implementing them searching for ways to streamline the process. There have been no published studies date on effect that electronic medical record systems (EMR) safety efficiency of β-lactam antibiotic desensitization. Objective: The purpose this study was evaluate changes in workflow, efficiency, errors after implementation Methods: A collaborative effort between Allergy/Immunology...