A5017799693- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Autoimmune Bullous Skin Diseases
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Inflammatory Bowel Disease
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Hepatitis B Virus Studies
- Gastrointestinal motility and disorders
- Acute Lymphoblastic Leukemia research
- Microscopic Colitis
- Peripheral Artery Disease Management
- Monoclonal and Polyclonal Antibodies Research
- Biliary and Gastrointestinal Fistulas
- Hemophilia Treatment and Research
- Eosinophilic Esophagitis
- Digestive system and related health
- Systemic Lupus Erythematosus Research
- Endoplasmic Reticulum Stress and Disease
- Gastroesophageal reflux and treatments
- Pharmaceutical studies and practices
Al-Mustafa International University
2017
University of Jordan
1985-2014
Jordan Hospital
1985-2013
Jordan University of Science and Technology
1999
Current treatments for long-term prophylaxis in hereditary angioedema have limitations.To assess the efficacy of lanadelumab, a fully human monoclonal antibody that selectively inhibits active plasma kallikrein, preventing attacks.Phase 3, randomized, double-blind, parallel-group, placebo-controlled trial conducted at 41 sites Canada, Europe, Jordan, and United States. Patients were randomized between March 2016, September 9, 2016; last day follow-up was April 13, 2017. Randomization 2:1...
Hereditary angioedema with C1 inhibitor deficiency is characterized by recurrent, unpredictable swelling episodes caused uncontrolled plasma kallikrein generation and excessive bradykinin release resulting from cleavage of high-molecular-weight kininogen. Lanadelumab (DX-2930) a new the potential for prophylactic treatment hereditary deficiency.We conducted phase 1b, multicenter, double-blind, placebo-controlled, multiple-ascending-dose trial. Patients were randomly assigned in 2:1 ratio to...
The burden of disease due to chronic viral hepatitis constitutes a global threat. In many Balkan and Mediterranean countries, the remains largely unrecognized, including in high-risk groups migrants, because lack reliable epidemiological data, suggesting need for better targeted surveillance public health gains. liver B C is increasing ageing unvaccinated populations migration, probable increase drug injecting. Targeted vaccination strategies virus (HBV) among risk harm reduction...
Extensive atherosclerotic plaque burden in the lower extremities often leads to symptomatic peripheral artery disease (PAD) including impaired walking performance and claudication. Interleukin-1β (IL-1β) may play an important pro-inflammatory role pathogenesis of this disease. Interruption IL-1β signaling was hypothesized decrease progression leg macrovasculature improve mobility patients with PAD intermittent Thirty-eight (mean age 65 years; 71% male) (confirmed by ankle–brachial index)...
Hereditary angioedema (HAE) is characterized by recurrent attacks of subcutaneous or submucosal edema. Attacks are unpredictable, debilitating, and have a significant impact on quality life. Patients may be prescribed prophylactic therapy to prevent attacks. Current treatments difficult administer (i.e., intravenously), require frequent administrations not well tolerated, breakthrough still occur frequently. Lanadelumab subcutaneously-administered monoclonal antibody inhibitor plasma...
The prevalence of coeliac disease among patients with autoimmune hypothyroidism has not been studied before in Jordan and other Arab countries.A cross-sectional record-based review was made all adult who attended a referral centre Jordan, during an 8-month period.Coeliac these diagnosed by the attending physician based on positive serological tests for anti-endomysial antibodies IgA IgG followed duodenal biopsy to confirm diagnosis disease.Of 914 recruited, 117 (12.8%) were seropositive 87...
A 50 year old man presented with progressive unilateral cranial nerve palsies (Garcin9s syndrome) for one year. Skull radiography and computed tomography (CT) showed intracranial extension of a soft tissue tumour from the right base skull. Necropsy revealed papillary cell carcinoma kidney metastases in
YLB113 is being developed as a biosimilar of the antitumor necrosis factor-alpha antagonist etanercept, which approved for treatment moderate-to-severe rheumatoid arthritis (RA) and other chronic immune-mediated inflammatory diseases. An open-label, crossover, pharmacokinetic study was conducted to compare relative bioavailability safety etanercept reference product (RP) Enbrel®. Healthy male subjects aged 18–50 years were randomized receive single subcutaneous dose in one period RP another...
This study was developed to document causes of rectal bleeding Jordanian patients and compare them with results from several parts the world.Diagnostic therapeutic colonoscopy used as a first-line investigation on 701 consecutive presenting bleeding. When indicated, technetium 99m-labeled red blood counts or selective angiography were also.Most common according frequency hemorrhoids, polyps, ulcerative colitis, amebic neoplasm, diverticulosis, anal fissure, Crohn's disease, arteriovenous...
Eight hundred Jordanians with liver enlargement were studied: 369 (46%) males and 431 (54%) females. Ages ranged between 13 85 years, a mean of 47.4%: 766 cases demonstrated single pathological process while 34 showed two or more processes. The most significant findings were: congestion secondary to cardiac failure in 323 (38.5%); inflammatory parasitic processes 192 (22.9%), including acute hepatitis (81 cases), hydatid cyst (63 chronic (27 abscess (19 brucellosis (one case) malaria case);...
Endoscopy within 24 hours from the onset of upper gastrointestinal (UGI) bleeding was carried out on 853 Jordanian patients. Lesions as a source were identified in 799 (93.7%) Radioactively tagged red blood cell (RBC) scan, angiography and follow-through radiography complementary studies endoscopy negative Etiology remained unidentified 16 The six most common causes UGI this study duodenal ulcer, gastric erosions, esophagitis, ulcer esophageal varices. Nonsteroidal anti-inflammatory drugs...
Tongue hyperpigmentation during treatment of hepatitis C virus (HCV) with pegylated interferon (Peg INF) and ribavirin considered a rare finding, we report case review literature to disclose this side effect HCV treatment. Twenty seven cases tongue pigmintation were reported (14 out 27) included the response in their reports,12 (12/14, 85.7%) had 8 (8/14, 57%) achieved sustained virological response(SVR); may raise question whether appearance pigmentation is marker treatment? There no...
Endoscopic retrograde cholangiopancreatography (ERCP) is the method of choice in establishing nature and site common bile pancreatic duct disease related complications. It was used 668 Jordanian patients who presented with biliary or unexplained upper abdominal pain. Common (CBD) stones, postsurgical traumatic CBD strictures, papillary stenosis malignant strictures were most findings this study. The incidence less injuries, mainly complete ligation, more than what reported by others. This...