A5038015477- Effects and risks of endocrine disrupting chemicals
- Pregnancy and Medication Impact
- Carcinogens and Genotoxicity Assessment
- Microplastics and Plastic Pollution
- Toxic Organic Pollutants Impact
- Sexual Differentiation and Disorders
- Environmental Toxicology and Ecotoxicology
- Birth, Development, and Health
- Estrogen and related hormone effects
- Pesticide Exposure and Toxicity
- Maternal Mental Health During Pregnancy and Postpartum
- Sperm and Testicular Function
- Pesticide and Herbicide Environmental Studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Marine Biology and Environmental Chemistry
- Heavy Metal Exposure and Toxicity
- Weed Control and Herbicide Applications
- Pharmacological Effects and Toxicity Studies
- Reproductive System and Pregnancy
- Animal testing and alternatives
- Stress Responses and Cortisol
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Testicular diseases and treatments
- Contact Dermatitis and Allergies
- Neuroendocrine regulation and behavior
Universidade Federal do Paraná
2016-2025
Creative Commons
2023
Instituto de Tecnologia do Paraná
2023
Icahn School of Medicine at Mount Sinai
2015-2022
Rigshospitalet
2022
Institut de Recherche en Santé, Environnement et Travail
2022
University of Copenhagen
2022
Karlstad University
2022
Inserm
2022
Aarhus University
2022
Polybrominated diphenyl ethers (PBDEs) are capable of disrupting thyroid hormone homeostasis. PBDE-47 (2,2',4,4'-tetrabromodiphenyl ether) is one the most abundant congeners found in human breast adipose tissue and maternal milk samples.We evaluated effects developmental exposure to low doses on female reproductive system.Pregnant Wistar rats were administered vehicle (peanut oil) or [140 700 microg/kg body weight (bw)] gestation day (GD) 6, 5 mg 6-n-propyl-2-thiouracil (PTU)/L drinking...
Glyphosate-based herbicides (GBHs) are broad-spectrum that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs human health subject an intense public debate for both its potential carcinogenic non-carcinogenic effects, including endocrine system present pilot study examine whether exposure to at dose glyphosate considered be "safe" (the US Acceptable Daily Intake - ADI 1.75 mg/kg bw/day), starting from utero life, affect development across different life...
Summary Prior studies report that penile size and male anogenital distance ( AGD ), sensitive markers of androgen action in utero, may be shortened by prenatal exposure to certain phthalates, including diethylhexyl phthalate DEHP but no human study has investigated the importance timing these associations. The aim this was examine significance on phthalates particular , infant . In Infant Development Environment Study TIDES ) we measured width PW as well anoscrotal AS anopenile AGP AP...
Phthalates, a class of chemicals used as plasticizers, are economically important due to several industrial applications. Di(2-ethylhexyl)phthalate (DEHP) is the most commonly phthalate plasticizer, and it has been described potent antiandrogen in males. We performed an extensive dose-response study following developmental exposure DEHP evaluated effects on female reproductive development. Two wide ranges doses that included dose levels relevant for human well high typically toxicological...
We examined the anogenital distance (AGD) plasticity in rats through manipulation of androgen environment utero and during puberty. Dams were treated from gestation days 13-20 with vehicle, flutamide (20mg/kg/day), di-(2-ethylhexyl) phthalate (DEHP, 750mg/kg/day), or testosterone (1.0mg/kg/day). After weaning, male pups randomly assigned to one four postnatal groups, which received same treatments given prenatally. Sixteen treatment groups established based on combination pre- exposures. The...
Phthalates are chemicals used in many industrial products (plastic toys, shampoos, soaps), and suspected of inducing adverse effects on the male reproductive system. In present study, we evaluated plasticizer di-(2-ethylhexyl)-phthalate (DEHP) function sexual behavior offspring rats, exposed utero during lactation (0, 20, 100 500 mg/kg per day by gavage). The produced clearly demonstrate ability DEHP to disrupt androgen-regulated development tract. Absolute relative weights...
Suppression of tau protein expression has been shown to improve behavioral deficits in mouse models tauopathies, offering an attractive therapeutic approach. Experimentally this had achieved by switching off the promoters controlling transgenic human gene (MAPT), which is not possible patients. The aim present study was therefore evaluate effectiveness small interfering RNAs (siRNAs) and their cerebral delivery suppress vivo, might be a option for tauopathies. We used primary cortical...
Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred analgesic for pain relief and fever during pregnancy. It has therefore caused concern that several studies have reported prenatal exposure to APAP results in developmental alterations both reproductive tract brain. Genitals nervous system of male mammals are actively masculinised foetal development early postnatal life by combined actions prostaglandins androgens, resulting male-typical behaviour seen adulthood. Both...
Summary The reproductive effects of the coadministration di‐2‐(ethylhexyl) phthalate (DEHP) and di‐butyl (DBP) were studied in both foetal adult male rat offspring exposed utero . Pregnant Wistar rats treated by oral gavage from gestation day 13 to 21 with vehicle control, 150 mg DEHP/kg body weight (bw)/day, 100 DBP/kg bw/ or a combination two compounds (DEHP + DBP mg/kg bw/day). An additional group dams received 500 bw/day. A significant decrease testicular testosterone levels was observed...