Charlotte Daker

ORCID: 0000-0001-5218-5973
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About
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Research Areas
  • Gastrointestinal motility and disorders
  • Gastroesophageal reflux and treatments
  • Helicobacter pylori-related gastroenterology studies
  • Diet and metabolism studies
  • Inflammatory Bowel Disease
  • Pathogenesis and Treatment of Hiccups
  • Child Nutrition and Feeding Issues
  • Gastrointestinal disorders and treatments
  • Eosinophilic Esophagitis
  • Traditional Chinese Medicine Studies
  • Health, psychology, and well-being
  • Clinical Nutrition and Gastroenterology
  • Colorectal Cancer Screening and Detection
  • Dysphagia Assessment and Management
  • Autoimmune and Inflammatory Disorders
  • Infant Health and Development
  • Diverticular Disease and Complications
  • Esophageal and GI Pathology
  • Pancreatic and Hepatic Oncology Research
  • Diagnosis and treatment of tuberculosis
  • Microscopic Colitis
  • Gastric Cancer Management and Outcomes
  • Urticaria and Related Conditions
  • Digestive system and related health
  • Dermatology and Skin Diseases

North Shore Hospital
2022-2024

Waitemata District Health Board
2022-2024

University of Calgary
2024

University of Auckland
2024

University of Otago
2018-2020

Christchurch Hospital
2019

University College London
2013

The Royal Free Hospital
2013

Chase Farm Hospital
2011-2012

Chronic nausea and vomiting syndromes (NVSs) are prevalent debilitating disorders. Putative mechanisms include gastric neuromuscular disease dysregulation of brain-gut interaction, but clinical tests for objectively defining motor function lacking. A medical device enabling noninvasive body surface mapping (BSGM) was developed applied to evaluate NVS pathophysiology. BSGM performed in 43 patients with matched controls using Gastric Alimetry (Alimetry), a conformable high-resolution array (8...

10.1126/scitranslmed.abq3544 article EN Science Translational Medicine 2022-09-21

INTRODUCTION: Body surface gastric mapping (BSGM) is a new noninvasive test of function. BSGM offers several novel and improved biomarkers function capable differentiating patients with overlapping symptom profiles. The aim this study was to define normative reference intervals for spectral metrics in population healthy controls. METHODS: performed controls using Gastric Alimetry (Alimetry, New Zealand) comprising stretchable high-resolution array (8 × 8 electrodes; 196 cm 2 ), wearable...

10.14309/ajg.0000000000002077 article EN The American Journal of Gastroenterology 2022-12-19

Gastric emptying testing (GET) assesses gastric motility, however, is nonspecific and insensitive for neuromuscular disorders. Alimetry (GA) a new medical device combining noninvasive electrophysiological mapping validated symptom profiling. This study assessed patient-specific phenotyping using GA compared with GET.

10.14309/ajg.0000000000002528 article EN cc-by-nc-nd The American Journal of Gastroenterology 2023-10-02

Introduction Disorders of gut-brain interaction (DGBIs) encompass a common group disorders characterised by chronic gastrointestinal symptoms. Psychological comorbidities are in patients with DGBIs and linked poorer patient outcomes. Consequently, assessing managing mental wellbeing may lead to improvements symptoms quality life. Methods This study aimed explore patients' clinicians' opinions on integrating psychometrics into routine DGBI testing. Semi-structured interviews were conducted 16...

10.7759/cureus.67155 article EN Cureus 2024-08-18

Chronic gastroduodenal symptoms are frequently overlapping within existing diagnostic paradigms, and current tests insensitive to underlying pathophysiologies. Gastric Alimetry has emerged as a new test of gastric neuromuscular function with time-of-test symptom profiling. This study aimed assess the impact diagnosis health care utilization after introduction into clinical care.

10.14309/ctg.0000000000000626 article EN cc-by-nc-nd Clinical and Translational Gastroenterology 2023-08-17

Background Chronic gastroduodenal disorders including, chronic nausea and vomiting syndrome, gastroparesis, functional dyspepsia, are challenging to diagnose manage. The diagnostic treatment pathways for these complex, costly overlap substantially; however, experiences of this pathway have not been thoroughly investigated. This study therefore aimed explore clinician patient perspectives on the current clinical pathway. Methods Semi-structured interviews were conducted between June 2020 2022...

10.3389/fpsyg.2023.1232871 article EN cc-by Frontiers in Psychology 2023-08-11

Abstract Objectives Gastric emptying testing (GET) assesses gastric motility, however is non-specific and insensitive for neuromuscular disorders. Alimetry® (GA) a new medical device combining non-invasive electrophysiological mapping validated symptom profiling. This study assessed patient-specific phenotyping using GA compared to GET. Methods Patients with chronic gastroduodenal symptoms underwent simultaneous GET GA, comprising 30-minute baseline, 99m TC-labelled egg meal, 4-hour...

10.1101/2023.05.18.23290134 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2023-05-25

Background: Current classification schemes for chronic gastroduodenal symptoms substantially overlap and therefore do not clearly guide patient-specific therapy. We hypothesized that a mechanism-based approach to symptom may offer valid more specific alternative scheme. Methods: performed multicentre prospective cohort study of patients meeting Rome-IV criteria functional dyspepsia (FD) nausea vomiting syndromes (CNVS). Gastric Alimetry™ (Alimetry, New Zealand) was used body surface gastric...

10.2139/ssrn.4517181 preprint EN 2023-01-01

Abstract Importance Chronic nausea and vomiting syndromes (NVS) are prevalent debilitating disorders. Putative mechanisms include gastric neuromuscular disease dysregulation of brain-gut interaction, but clinical tests for objectively defining motor function lacking. Objective A novel medical device enabling non-invasive body surface mapping (BSGM) was developed applied to evaluate NVS pathophysiology. Design case-control study where BSGM performed in patients matched controls using Gastric...

10.1101/2022.02.07.22270514 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2022-02-08

Chronic gastroduodenal symptoms are common but remain a diagnostic challenge. The underlying mechanisms of chronic heterogeneous, including gastric dysmotility, hypersensitivity, gut-brain axis dysregulation, pyloric resistance, duodenal immune and other causes. Gastric Alimetry® (New Zealand) is new test function, employing simultaneous body surface mapping (BSGM) validated symptom profiling. These provide synergistic data for more accurate profiling neuromuscular disorders to enable...

10.2139/ssrn.4425865 article EN SSRN Electronic Journal 2023-01-01

Abstract Objective To define phenotypes of gastric myoelectrical abnormalities and relation to symptoms in people with longstanding T1D, compared matched healthy controls, using a novel non-invasive body surface mapping (BSGM) device. Research design methods BSGM was performed on T1D >10 years duration employing Gastric Alimetry (Alimetry, New Zealand), comprising high-resolution 64-channel array, validated symptom logging App, wearable reader. Results 32 were recruited (15 high burden),...

10.1101/2022.08.10.22278649 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2022-08-11

Abstract Introduction Body surface gastric mapping (BSGM) is a new non-invasive test of function. BSGM offers several novel and improved biomarkers function capable differentiating patients with overlapping symptom-profiles. The aim this study was to define normative reference intervals for spectral metrics in population healthy controls. Methods performed controls using Gastric Alimetry (Alimetry, New Zealand) comprising stretchable high-resolution array (8×8 electrodes; 196 cm 2 ),...

10.1101/2022.07.25.22278036 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2022-07-26

Abstract Background Chronic gastroduodenal disorders such as chronic nausea and vomiting syndrome (CNVS), functional dyspepsia (FD) gastroparesis, are more prevalent among young women, many of whom hormonal contraception users. We aimed to evaluate the effects on symptom severity gastric myoelectrical activity in people with disorders. Methods This analysis was conducted a large international cohort patients who met Rome IV criteria for CNVS or FD had undergone body surface mapping using...

10.1101/2024.04.20.24306132 preprint EN cc-by-nd medRxiv (Cold Spring Harbor Laboratory) 2024-04-22

Chronic nausea and vomiting syndromes (CNVS), gastroparesis functional dyspepsia (FD) are complex disorders. Body Surface Gastric Mapping (BSGM), a new test of gastric function, using Alimetry® (Alimetry, New Zealand) may be useful for de-escalating healthcare utilisation. This study aimed to define costs estimate health economic impacts implementing this in patients with chronic gastroduodenal symptoms. Consecutive at tertiary referral centre evaluated Alimetry were included. Frequency cost...

10.1007/s10620-024-08455-0 article EN cc-by-nc Digestive Diseases and Sciences 2024-04-30

Abstract Background Many diagnostic tests for gastroduodenal symptoms, such as gastric emptying scintigraphy (GES), breath (GEBT), and electrogastrography (EGG) show variable intra‐individual reproducibility over time. This study investigated the short‐ long‐term of body surface mapping (BSGM), a non‐invasive test assessing function, in controls patients with chronic disorders. Methods Participants completed three standardized BSGM using Gastric Alimetry® (Alimetry, New Zealand). The...

10.1111/nmo.14812 article EN cc-by Neurogastroenterology & Motility 2024-04-30

Objective There is currently a lack of validated questionnaires designed specifically to assess mental health within patients with chronic gastroduodenal symptoms. This research describes the multi-phase process used develop and validate novel scale for symptoms, Alimetry® Gut-Brain Wellbeing (AGBW) Survey. Methods A patient-centered was implemented. In Phase 1, most relevant concepts this patient population were selected from existing scales, using data 79 patients. 2, an interdisciplinary...

10.3389/fpsyg.2024.1389671 article EN cc-by Frontiers in Psychology 2024-07-08

<b><i>Background:</i></b> Inflammatory Bowel Disease (IBD) can have considerable effects on employment outcomes because of its disabling character. <b><i>Goals:</i></b> We aimed to investigate the impact IBD in workplace and better understand need for accommodations adaptations. <b><i>Study:</i></b> Between November 2017 March 2018, patients were recruited from outpatient clinics Christchurch Hospital, New Zealand. The...

10.1159/000506702 article EN cc-by-nc-nd Inflammatory Intestinal Diseases 2020-01-01

Abstract Background Psychological comorbidities are common in patients with disorders of gut-brain interaction (DGBIs) and often linked poorer patient outcomes. Likewise, extensive research has shown a bidirectional association between psychological factors gastrointestinal symptoms, termed the axis. Consequently, assessing managing mental wellbeing, an integrated care pathway, may lead to improvements symptoms quality life for some patients. This study aimed explore patients’...

10.1101/2023.06.06.23291063 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2023-06-10

Electrogastrography (EGG) non-invasively evaluates gastric motility but is viewed as lacking clinical utility. Gastric Alimetry® a new diagnostic test that combines high-resolution body surface mapping (BSGM) with validated symptom profiling, the goal of overcoming EGG's limitations. This study directly compared EGG and BSGM to define performance differences in spectral analysis. Comparisons between Alimetry were conducted by protocolized retrospective evaluation 178 subjects [110 controls;...

10.1038/s41598-023-41645-w article EN cc-by Scientific Reports 2023-09-11
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