A5046055402- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- Dysphagia Assessment and Management
- Eosinophilic Esophagitis
- Pelvic floor disorders treatments
- Anorectal Disease Treatments and Outcomes
- Esophageal Cancer Research and Treatment
- Hernia repair and management
- Helicobacter pylori-related gastroenterology studies
- Tracheal and airway disorders
- Pelvic and Acetabular Injuries
- Diverticular Disease and Complications
- Respiratory and Cough-Related Research
- Gastrointestinal motility and disorders
- Potassium and Related Disorders
- Neuroscience of respiration and sleep
- Urinary Bladder and Prostate Research
- Obstructive Sleep Apnea Research
- Congenital Diaphragmatic Hernia Studies
- Gastrointestinal disorders and treatments
- Systemic Sclerosis and Related Diseases
- Cardiac Imaging and Diagnostics
- Restless Legs Syndrome Research
- Gastric Cancer Management and Outcomes
- Protein Tyrosine Phosphatases
University of California, San Diego
2016-2025
University of California, Irvine
2003-2024
University of California San Diego Medical Center
2002-2021
VA San Diego Healthcare System
2006-2021
UC San Diego Health System
2008-2017
United States Department of Veterans Affairs
1986-2016
University Gastroenterology
1987-2014
University of California System
2008-2011
Universidade Federal do Rio de Janeiro
2010
Medical College of Wisconsin
1991-2006
Abstract Background Criteria for transient lower esophageal sphincter relaxations ( TLESR s) are well‐defined Dentsleeve manometry. As high‐resolution manometry HRM ) is now the gold standard to assess motility, our aim was propose a consensus definition of s using . Methods Postprandial combined with impedance performed in 10 patients gastroesophageal reflux disease. Transient identification by 17 experts Delphi process. Four investigators then characterized candidates that achieved 100%...
To determine if hiatus hernia (HH) contributes to the delayed clearance of acid from esophagus in patients with gastroesophageal reflux (GER), we performed simultaneous esophageal pH recordings and radionuclide studies three study populations: 12 GER HH, 5 no 8 subjects HH but symptoms. Acid was measured at cm. above manometrically located lower sphincter (LES) after injecting a 15-ml. bolus 0.1 N HCl 15 LES. The labeled 200 mu Ci 99mTc-sulfur colloid. also 10 LES injection 20 faster...
Abstract Objectives Proton‐pump inhibitors are often recommended in the treatment of laryngitis secondary to gastric reflux. Despite prospective studies reporting high efficacy, only one previous report has been placebo‐controlled and blinded. The objective this study was determine efficacy omeprazole treating proven reflux laryngitis. Study Design Prospective, placebo‐controlled, randomized, double‐blind clinical trial. Methods Fifty‐three patients with or more symptoms were recruited...
To determine the effect of contraction diaphragm on lower esophageal sphincter (LES) pressure, we studied eight healthy volunteers during spontaneous breathing, maximal inspiration, and graded inspiratory efforts against a closed airway (Muller's maneuver). Electrical activity crural (DEMG) was recorded from bipolar electrodes, transdiaphragmatic pressure (Pdi) calculated as difference between gastric pressures, LES using sleeve device. During phasic DEMG accompanied by increases in Pdi...
Heartburn occurs in the presence as well absence of acid reflux. We searched for a motor correlate heartburn. Twelve subjects with heartburn were studied 24-h synchronized pressure, pH, and high-frequency intraluminal ultrasound (HFIUS) imaging esophagus. The HFIUS images analyzed every 2 s period min before 30 after onset during 20 reflux-positive reflux-negative episodes. esophageal muscle thickness was measured marker contraction. Esophageal pressure recorded Bernstein test 15 subjects....
We studied the effects of involuntary and voluntary contraction diaphragm on esophagogastric junction (EGJ) pressure during esophageal distension in healthy human volunteers. The EGJ was monitored using a Dent sleeve device. Along with we concurrently electromyogram (EMG) intra-esophageal bipolar electrodes that were placed nonpressure sensing surface Graded distensions performed by graded inflations 2-cm-diameter balloon positioned 7 cm above EGJ. caused increase amplitude lower sphincter...
<h3>Background:</h3> Oesophageal motility, as measured by manometry, is normal in the majority of patients with eosinophilic oesophagitis (EO). However, manometry measures only circular muscle function oesophagus. The goal present study was to assess and longitudinal during peristalsis EO. <h3>Methods:</h3> Ultrasound imaging were simultaneously acquired swallow-induced EO controls measure contraction, respectively. A probe an ultrasound transducer positioned 2 cm then 10 above lower...
BACKGROUND Patients with achalasia, diffuse esophageal spasm (DES), and nutcracker esophagus have a thicker muscularis propria than normal subjects. The goal of our study was to determine the prevalence increased muscle thickness in group unselected patients referred function laboratory for evaluation symptoms. METHODS We studied 40 subjects 94 consecutive patients. Manometry ultrasound images were recorded concurrently, using special custom-built catheter. Esophageal cross-sectional area...
Background Anal sphincter complex consists of anatomically overlapping internal anal (IAS), external (EAS) and puborectalis muscle (PRM). We determined the functional morphology muscles using high definition manometery (HDAM), three dimensional (3D)-ultrasound (US) Magnetic resonance (MR) imaging. Methods studied 15 nulliparous women. High probe equipped with 256 pressure transducers was used to measure canal pressures at rest squeeze. Lengths IAS, PRM, EAS were from 3D-US images...