A5021001366- Cancer Cells and Metastasis
- Cancer Research and Treatments
- S100 Proteins and Annexins
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Neonatal Respiratory Health Research
- Ferroptosis and cancer prognosis
- Biomarkers in Disease Mechanisms
- Microtubule and mitosis dynamics
- TGF-β signaling in diseases
- Immunotherapy and Immune Responses
- Hedgehog Signaling Pathway Studies
- Liver physiology and pathology
- DNA Repair Mechanisms
- Cancer Genomics and Diagnostics
- Virus-based gene therapy research
- Hippo pathway signaling and YAP/TAZ
Seoul National University
2018-2023
Namseoul University
2023
Yanbian University
2020
To understand the potential effects of cancer cells on surrounding normal mammary epithelial cells, we performed direct co-culture non-tumorigenic MCF10A and various breast cells. Firstly, observed dynamic cell-cell interactions between including lamellipodia or nanotube-like contacts transfer extracellular vesicles. Co-cultured exhibited features epithelial-mesenchymal transition, showed increased capacity cell proliferation, migration, colony formation, 3-dimensional sphere formation....
Abstract Background Tenascin-C (TNC) is an extracellular matrix protein that widely expressed in the stromal fibroblasts of various cancers. However, roles TNC colorectal cancer (CRC) cells remain unclear. Methods The expression TNC, stem cell-like (CSC) and cell cycle markers, Hedgehog (HH) signaling pathway genes were assessed 100 paraffin embedded clinical CRC patient tissues using immunohistochemistry. interaction between CSC marker or HH related detected by immunofluorescence. Cell...
Chromosomal instability (CIN) contributes to intercellular genetic heterogeneity and has been implicated in paclitaxel (PTX) resistance breast cancer. In this study, we explored polo-like kinase 1 (PLK1) as an important regulator of mitotic integrity a useful predictive biomarker for PTX cancer.We performed screening using the human kinome CRISPR/Cas9 library cancer cells. vitro cell proliferation apoptosis assays vivo xenograft experiments were determine effects PLK1 on Immunofluorescence...
Abstract To understand the potential effects of cancer cells on surrounding normal mammary epithelial cells, we performed direct co-culture non-tumorigenic MCF10A and various breast cells. Firstly, observed dynamic cell-cell interactions between including lamellipodia or nanotube-like contacts transfer extracellular vesicles. Co-cultured exhibited features epithelial-mesenchymal transition, showed increased capacity cell proliferation, migration, colony formation, 3-dimensional sphere...
Abstract Although the established cancer cell lines exhibit less degrees of intratumoral heterogeneity when compared to human solid tumors, studies have suggested that, even within same line, substantial degree may exist. In this study, we performed single cloning experiment using 4T1 mouse mammary carcinoma line and phenotypes different clones. When parental one clone (C12) showed markedly phenotype by exhibiting aggressive features in vitro significantly slower tumor growth metastasis...
Abstract As a new promising in vivo platform for personalized treatment the field of cancer research, most improved way has been adopted by far is grafting patient-derived xenograft (PDX) to humanized mouse models which represent unique features interaction with human immune system and tumor microenvironment (TME). Here, we engineered triple negative breast (TNBC) PDX (Hu-PDX) model observe growth TME. In addition, analyzed gene ontology isolated from hu or non-humanized model. Method: Human...
Abstract Objective Immunotherapy using the tumor-specific antigens (TSAs) is a promising strategy in breast cancer. Studies have suggested that vivo exposures to certain tumors can induce adaptive anti-tumor immunity syngeneic tumor models. In this study, we show efficacy of lysate vaccine and peptide-based against neoantigen suppressing growth metastasis 4T1 Method We used BALB/c mice its cell lines evaluate effect induced by transient exposure cells. For vaccines, synthesized freeze-thaw...