A5081274685- Extracellular vesicles in disease
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Nanoplatforms for cancer theranostics
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Sensor Technology and Measurement Systems
- Aldose Reductase and Taurine
- Histone Deacetylase Inhibitors Research
- Neural Networks and Applications
- Magnetic Field Sensors Techniques
- Sarcoma Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- HER2/EGFR in Cancer Research
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Advanced Breast Cancer Therapies
- RNA modifications and cancer
- Prostate Cancer Treatment and Research
- Cancer Treatment and Pharmacology
Seoul National University
2018-2024
Seoul National University Hospital
2018-2024
Korea Advanced Institute of Science and Technology
2012-2024
Abstract Patients with triple-negative breast cancer (TNBC) often develop metastases in visceral organs including the liver, but detailed molecular mechanisms of TNBC liver metastasis is not clearly understood. In this study, we tried to dissect process premetastatic niche formation by using patient-derived xenograft (PDX) models different metastatic propensity. RNA sequencing PDX that successfully metastasized showed upregulation Cx3cr1 gene microenvironment. syngeneic models, preceded...
Patients with triple-negative breast cancer (TNBC) have an increased risk of distant metastasis compared to those other subtypes. In this study, we aimed identify the genes associated in TNBC and their underlying mechanisms.We established patient-derived xenograft (PDX) models using surgically resected tissues from 31 patients TNBC. Among these, 15 subsequently developed metastases. Candidate metastasis-associated were identified RNA sequencing. vitro wound healing, proliferation, migration,...
Paclitaxel is a cytotoxic chemotherapy commonly used in patients with triple negative breast cancer (TNBC); however, the resistance to paclitaxel cause of poor response patients. The aim this study was examine role protein phosphatase 1H (PPM1H) patients.To investigate function PPM1H treatment, we conducted vitro assays and molecular experiments using stable cell line (MDA-MB-231) which overexpressed. We also performed analyses on patient tissue samples. Molecular expression related analyzed...
Malignant phyllodes tumour (MPT) is a rare breast malignancy with epithelial and mesenchymal features. Currently, there are no appropriate research models or effective targeted therapeutic approaches for MPT.We collected fresh frozen tissues from nine patients MPT performed whole-exome RNA sequencing. Additionally, we established patient-derived xenograft (PDX) tested the efficacy of targeting dysregulated pathways in using PDX model one MPT.MPT has unique molecular characteristics when...
Abstract Triple-negative breast cancer (TNBC) is the most heterogeneous and aggressive tumor subtype defined by absence of receptor for estrogen, progesterone, or HER2. However, biologic mechanism TNBC phenotype still unclear. Here, we show that expression Calsequestrin 2 (CASQ2), a Ca2+-binding protein, correlates with increase proliferation, migration, invasion, suggesting intracellular Ca2+ may contribute to growth metastatic phenotype. CASQ2 main protein inside sarcoplasmic reticulum...
In this study, we aimed to establish humanized patient-derived xenograft (PDX) models for triple-negative breast cancer (TNBC) using cord blood (CB) hematopoietic stem cells (HSCs). Additionally, attempted characterize the immune microenvironment of PDX model understand potential implications altered tumor-immune interactions in on behavior TNBC cells.
Abstract Objective: In the cancer research, a highly promising in vivo platform for personalized treatment involves adoption of an advanced approach—specifically, grafting patient-derived xenografts (PDX) onto humanized mouse models. These models capture distinctive aspects interaction with human immune system and tumor microenvironment (TME). this study, we have engineered triple-negative breast (TNBC) PDX to observe alterations differentially expressed genes, thereby enhancing our...
<div>Abstract<p>Triple negative breast cancer (TNBC) patients often develop metastases in visceral organs including the liver but detailed molecular mechanisms of TNBC metastasis is not clearly understood. In this study, we tried to dissect process pre-metastatic niche formation by using patient-derived xenograft (PDX) models with different metastatic propensity. RNA sequencing PDX that successfully metastasized showed up-regulation Cx3cr1 gene microenvironment. syngeneic models,...
Abstract Triple-negative breast cancer (TNBC) is associated with a high risk of distant metastasis, particularly to the lung and liver. Both intrinsic characteristics cells tumor microenvironment (TME) influence TNBC growth metastasis. The TME, comprising stromal, immune, endothelial cells, exhibits heterogeneity both between within cell types. Identifying molecular TME that affect progression crucial. We aim investigate this using single-cell RNA sequencing patient-derived xenograft (PDX)...
Abstract The tumor microenvironment (TME), which the cancer is known to remodel, can interact with in various ways, such as promoting or hindering metastasis. challenge comprehending TME that each patient's individual variance makes it difficult carry out a consistent analysis. We used PDX model analyze alterations entirely brought about by cells of patient same environment exclusively. In 121 breast patients, we created and performed WES RNA-seq. repeatedly metastatic induction tests on...
<div>Abstract<p>Patients with triple-negative breast cancer (TNBC) often develop metastases in visceral organs including the liver, but detailed molecular mechanisms of TNBC liver metastasis is not clearly understood. In this study, we tried to dissect process pre-metastatic niche formation by using patient-derived xenograft (PDX) models different metastatic propensity. RNA sequencing PDX that successfully metastasized showed upregulation <i>Cx3cr1</i> gene...
<div>Abstract<p>Triple negative breast cancer (TNBC) patients often develop metastases in visceral organs including the liver but detailed molecular mechanisms of TNBC metastasis is not clearly understood. In this study, we tried to dissect process pre-metastatic niche formation by using patient-derived xenograft (PDX) models with different metastatic propensity. RNA sequencing PDX that successfully metastasized showed up-regulation Cx3cr1 gene microenvironment. syngeneic models,...
<div>Abstract<p>Patients with triple-negative breast cancer (TNBC) often develop metastases in visceral organs including the liver, but detailed molecular mechanisms of TNBC liver metastasis is not clearly understood. In this study, we tried to dissect process premetastatic niche formation by using patient-derived xenograft (PDX) models different metastatic propensity. RNA sequencing PDX that successfully metastasized showed upregulation <i>Cx3cr1</i> gene...
Abstract Triple Negative Breast Cancer (TNBC) is uncommon type of invasive breast cancer accounting for about 10~20% all cancers. TNBC characterized by a lack expression estrogen receptors (ER), human epidermal growth factor receptor 2 (HER2) and progesterone (PR). Due to this characteristic, common treatments including hormone therapy drugs targeting these are not effective against despite more aggressive clinical behavior when compared other subtypes. Paclitaxel one the well-known...
Abstract Triple negative breast cancer (TNBC) is a subtype with increased risk of distant metastasis, especially to visceral organs. However, the detailed molecular mechanism underlying metastasis TNBC unknown. We used three patient-derived xenograft models derived from tumors different metastatic capacities. PDX1 and PDX2 model developed in only lung liver, respectively. In contrast, PDX3 tumor metastasized both liver. RNA sequencing primary sites these PDX was performed. The gene...