A5034705146- Ion channel regulation and function
- Microtubule and mitosis dynamics
- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Cancer Treatment and Pharmacology
Seoul National University
2020
Seoul National University Hospital
2018
Paclitaxel is a cytotoxic chemotherapy commonly used in patients with triple negative breast cancer (TNBC); however, the resistance to paclitaxel cause of poor response patients. The aim this study was examine role protein phosphatase 1H (PPM1H) patients.To investigate function PPM1H treatment, we conducted vitro assays and molecular experiments using stable cell line (MDA-MB-231) which overexpressed. We also performed analyses on patient tissue samples. Molecular expression related analyzed...
Abstract Triple-negative breast cancer (TNBC) is the most heterogeneous and aggressive tumor subtype defined by absence of receptor for estrogen, progesterone, or HER2. However, biologic mechanism TNBC phenotype still unclear. Here, we show that expression Calsequestrin 2 (CASQ2), a Ca2+-binding protein, correlates with increase proliferation, migration, invasion, suggesting intracellular Ca2+ may contribute to growth metastatic phenotype. CASQ2 main protein inside sarcoplasmic reticulum...