A5085220074- BRCA gene mutations in cancer
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- CRISPR and Genetic Engineering
- Cell Image Analysis Techniques
- Machine Learning and Data Classification
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- PARP inhibition in cancer therapy
- Reproductive tract infections research
- Advanced Breast Cancer Therapies
- Chromatin Remodeling and Cancer
- COVID-19 Clinical Research Studies
- Microtubule and mitosis dynamics
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- MicroRNA in disease regulation
Seoul National University
2022-2025
Seoul National University Hospital
2019-2023
Kangbuk Samsung Hospital
2022
Various miRNAs play critical roles in the development and progression of solid tumors. In this study, we describe role miR-204-5p limiting growth breast cancer. cancer tissues, was significantly downregulated compared with normal its expression levels were associated increased survival outcome patients Overexpression inhibited viability, proliferation, migration capacity human murine cells. addition, overexpression resulted a significant alteration metabolic properties cells suppression...
Abstract Single-cell transcriptomics enables the study of cellular heterogeneity, but current unsupervised strategies make it challenging to associate individual cells with sample conditions. We propose scMILD, a weakly supervised learning framework based on Multiple Instance Learning, which leverages sample-level labels identify condition-associated cell subpopulations. scMILD employs dual-branch architecture perform classification and cell-level representation simultaneously. validated...
Abstract Breast cancer (BC) in patients with germline mutations of BRCA1/BRCA2 are associated benefit from drugs targeting DNA damage response (DDR), but they account for only 5–7% overall breast cancer. To define the characteristics these tumors and also to identify without BRCA mutation homologous recombination deficiency (HRD) is clinically relevant. characteristic features HRD analyze correlations between BC subtypes, we analyzed 981 TCGA database using signature analyzer. The was...
Germline mutations of breast cancer susceptibility gene BRCA1 and BRCA2 (gBRCA1/2) are associated with elevated risk in young women Asia. proteins contribute to genomic stability through homologous recombination (HR)-mediated double-strand DNA break repair cooperation other HR-related proteins. In this study, we analyzed the targeted sequencing data Korean patients gBRCA1/2 investigate alterations genes their clinical implications.
In the present study, we aimed to establish a liquid biopsy-based monitoring method using peripheral blood cell-free DNA (cfDNA) for patients with cervical cancer who underwent radical radiotherapy (RT). Twenty-five were prospectively recruited and treated external beam RT brachytherapy. all patients, except one, chemotherapy was administered concurrently during RT. Whole samples obtained at least twice from each patient. We performed next-generation sequencing (NGS) target-captured...
Paclitaxel is a cytotoxic chemotherapy commonly used in patients with triple negative breast cancer (TNBC); however, the resistance to paclitaxel cause of poor response patients. The aim this study was examine role protein phosphatase 1H (PPM1H) patients.To investigate function PPM1H treatment, we conducted vitro assays and molecular experiments using stable cell line (MDA-MB-231) which overexpressed. We also performed analyses on patient tissue samples. Molecular expression related analyzed...
Abstract In single-cell transcriptome analysis, numerous biomarkers related to COVID-19 severity, including cell subtypes, genes, and pathways, have been identified. Nevertheless, most studies focused on severity groups based clinical features, neglecting immunological heterogeneity within the same level. this study, we employed sample-level clustering using cell-cell interaction scores investigate patient uncover novel subtypes. The results were validated external datasets, demonstrating...
Abstract In single-cell transcriptome analysis, numerous biomarkers related to COVID-19 severity, including cell subtypes, genes, and pathways, have been identified. Nevertheless, most studies focused on severity groups based clinical features, neglecting immunological heterogeneity within the same level. this study, we employed sample-level clustering using cell-cell interaction scores investigate patient uncover novel subtypes. The results were validated external datasets, demonstrating...
Abstract Background Germline mutations of breast cancer susceptibility gene BRCA1 and BRCA2 (gBRCA1/2) are associated with elevated risk in young women Asia. proteins contribute to genomic stability through homologous recombination (HR)-mediated double strand DNA break repair (DDR) cooperation other HR-related proteins. In this study, we analyzed the targeted sequencing data patients gBRCA1/2 investigate landscape their clinical implications. Materials Methods Data pathogenic qualified next...
Background: Hypoxia is a well-recognized characteristic of the tumor microenvironment solid cancers. This study aimed to analyze hypoxia-related genes shared by groups based on location. Methods: A total 9 pathways from Kyoto Encyclopedia Genes and Genomes database or Reactome were selected, 850 analyzed. Based their anatomical locations, 14 types categorized into 6 groups. The group-specific genetic risk score was classified as high- low-risk mRNA expression, survival outcomes evaluated....
Abstract The most reliable predictive biomarker of cancer immunotherapy is gene expression profile (GEP) tumor microenvironment. GEPs such as local immune cytolytic activity, interferon-gamma signature, and signature score have been reported to represent anti-tumor signature. Previously, we that was positively correlated with mutational burden, but negatively chromosomal instability (CIN) score, since tumors high CIN had significantly low neoantigen burden. However, methylation or burden...
Introduction: Determining immunogenicity of tumors is important in predicting response to cancer immunotherapy. Tumor mutation burden, the degree copy number variation expressed as chromosomal instability score and gene expression profiles (GEP) tumors, such cytolytic activity score, interferon-gamma signature immune signature, are known biomarkers immunogenicity. However, correlation between methylation burden tumor unknown.Methods: We used The Cancer Genome Atlas (TCGA) pan-cancer database...
Abstract Introduction: Determining immunogenicity of tumors is important in predicting response to cancer immunotherapy. Tumor mutation burden, the degree copy number variation expressed as chromosomal instability score and gene expression profiles (GEP) tumors, such cytolytic activity score, interferon-gamma signature immune signature, are known biomarkers immunogenicity. However, correlation between methylation burden tumor unknown. Methods: We used The Cancer Genome Atlas (TCGA)...
Abstract Background Germline mutations of breast cancer susceptibility gene BRCA1 and BRCA2 ( gBRCA1/2 ) are associated with elevated risk in young women Asia. proteins contribute to genomic stability through homologous recombination (HR)-mediated double strand DNA break repair cooperation other HR-related proteins. In this study, we analyzed the targeted sequencing data patients investigate landscape their clinical implications. Materials Methods Data pathogenic qualified next generation...
Abstract Hypoxia is a well-recognized characteristic of the tumor microenvironment solid cancers. This study aimed to analyze hypoxia-related genes shared by groups based on location. Nine pathways from Kyoto Encyclopedia Genes and Genomes database or Reactome were selected, 850 analyzed. Based their anatomical locations, 14 types categorized into following six groups. The group-specific genetic risk score was classified as high low mRNA expression, survival outcomes evaluated. scores in...