A5067837609- Sodium Intake and Health
- Nitric Oxide and Endothelin Effects
- Diabetes and associated disorders
- Tryptophan and brain disorders
- Immune responses and vaccinations
- Gut microbiota and health
- T-cell and B-cell Immunology
- Blood Pressure and Hypertension Studies
University Hospital Bonn
2020-2021
University of Bonn
2020
Although it is well established that microbial infections predispose to autoimmune diseases, the underlying mechanisms remain poorly understood. After infection, tissue-resident memory T (TRM) cells persist in peripheral organs and provide immune protection against reinfection. However, whether TRM participate responses unrelated primary such as inflammation, unknown. By using high-dimensional single-cell analysis, we identified CD4+ with a TH17 signature (termed TRM17 cells) kidneys of...
A high-salt diet in mice and humans impairs neutrophil antibacterial functions by dysregulating immunosuppressive steroid hormones.
Significance Statement The advent of second-generation radiofrequency ablation has renewed interest in renal denervation (RDN) to treat patients with drug-resistant arterial hypertension. In this study, we demonstrate that RDN-induced alterations glomerular perfusion and filtration have hitherto unknown consequences for inflammatory kidney diseases. Denervated kidneys are more susceptible immune complex GN or endotoxin-induced inflammation. contrast, the improved GFR denervated provides...