The present study was performed to examine the effect of Eugenia caryophyllata (Myrtaceae) on learning and memory, also evaluate whether it can modulate oxidative stress in mice. Passive avoidance step-down task elevated plus-maze were used assess memory scopolamine-treated Oxidative parameters assessed brain samples by estimating malondialdehyde (MDA) reduced glutathione (GSH) levels at end study. Scopolamine (0.3 mg/kg, i. p.) produced impairment acquisition as evidenced a decrease latency...

The present study was undertaken to explore the effect of essential oil isolated from buds Eugenia caryophyllata on some immunological parameters. Humoral immunity assessed by measuring hemagglutination titre sheep red blood cells and delayed type hypersensitivity foot pad thickness. Clove administration produced a significant increase in primary as well secondary humoral immune response. In addition, it also decrease thickness compared with control group. Thus, these results suggest that...

Cadmium (Cd) is a known pollutant present in the environment at low levels and reported to affect reproduction many ways. The study was undertaken explore effect of Cd F1 generation mice on cognitive parameters, further investigate whether quercetin could modulate these effects. In this study, female lactating were exposed cadmium for seven days just after delivery. new born pups their adulthood tested learning memory parameters by passive avoidance task Morris water maze (MWM) test. It...

Aloe vera (barbadensis Mill., Family Liliaceae) since ancient times has been used for the treatment of skin disorders, infection, and as a laxative. The present study was undertaken to explore effect A. (Family in animal models learning memory, depression, locomotion.To assess passive avoidance task elevated plus-maze were used. For evaluating forced swim test tail suspension performed, locomotor activity, rota rod photoactometer used.A. (200 400 mg/kg, p.o.) found significantly increase...

Combination of opioid and potassium channel openers holds immense potential for the treatment most acute chronic pain. Therefore, study was performed to assess interaction between morphine K(+) -channel openers. Swiss albino mice either sex weighing 25 30 g were used study. The assesses (cromakalim, diazoxide minoxidil), when administered intraperitoneally, using formalin tail-flick tests in mice. Both produced significant antinociception at higher doses both behavioral tests. Lower had no...

The present study aims to investigate the influence of electrical stimulation periaqueductal gray (PAG) following peripheral nerve injury and its modulation by naloxone N-methyl-D-aspartate (NMDA). Chronic neuropathic pain was induced chronic constriction sciatic nerve, subsequently a cannula implanted in PAG area for purpose intra-PAG drug administration. Intra-PAG administration morphine, ketamine, their combination were found elicit antinociceptive response on hot-plate test. Electrical...

Abstract Background: The efficacy of opioids in neuropathic pain is still controversial. Earlier studies have suggested that N-methyl-D-aspartate (NMDA) receptor binding can be affected by and vice versa. present study aims to explore the interactions between NMDA opioid receptors using various combinations drugs acting on these receptors. Methods: We used an animal model sciatic nerve ligation induce pain, a hot-plate test was assess response. Results: It observed naloxone increased...

The essential oil of Eugenia caryophyllata (clove oil; Family: Myrtaceae) is used in dental care as an antiseptic and analgesic. present study investigates the effect clove on animal models depression locomotion.Clove was administered doses 0.025, 0.05, 0.1 ml/kg/day, intraperitoneally (i.p.) for 3 weeks. forced swim test (FST) tail suspension (TST) were to assess depression. To evaluate locomotor activity, rota rod photoactometer procedure performed.In FST, it observed that duration...

Propoxur (a carbamate pesticide) has been shown to adversely affect memory and induce oxidative stress on both acute chronic exposure. This study was designed explore the modulation of effects propoxur over cognitive function by melatonin (MEL). Cognitive assessed using step-down latency (SDL) a passive avoidance apparatus, transfer (TL) an elevated plus maze. Oxidative examining brain malondialdehyde (MDA) reduced glutathione (GSH) levels catalase (CAT) activity. A significant reduction in...

Ovarian cancer is associated with a high relapse rate and the fifth leading cause of deaths in women. The genetic profile tumor responsible for deciding response to chemotherapeutic agents. In this study, we investigate relation between survivin p53 expression agents primary cultures ovarian cells established from ascitic fluid.Ascitic fluid Dulbecco's modified Eagle medium was mixed equal proportion culture flasks incubated establish culture. were treated different combinations carboplatin...

Long term effects of COVID are not fully understood yet. The geriatric population has been badly affected. impact COVID-19 on the health-related quality life after recovery and patient compliance is a matter concern especially in where polypharmacy often prevalent.This study intended to observe occurrence (PP) among recovered older patients with multimorbidity explore its association these patients.Total 90 patients, above 60 years age having two or more co-morbidities from infection were...

Objective: This study was planned to evaluate the correlation between cost borne by patient and medication adherence in common mental disorder patients during COVID-19 pandemic. Methods: A descriptive cross-sectional drug utilization undertaken 200 patients. Pattern of psychotropic drugs usage analyzed as per WHO/INRUD guidelines average monthly patient/hospital prescription correlated with Results: The costs hospital were observed be more pandemic compared pre-pandemic time. It that bearing...

Background: The increased use of Cr in several anthropogenic activities and subsequent contamination water soil is an increasing concern worldwide. It has also recently drawn attention for its widespread dietary supplements. Objective: In this study we proposed to whether chromium (Cr) could alter the antioxidant enzymes brain their gene expression F1 mice when administered dams during gestation quercetin modulate effect. Methods: Animals were alone combination with seven days period....

Pharmacognosy Research,2020,12,2,169-175.DOI:10.4103/pr.pr_93_19Published:May 2020Type:Original ArticleAuthors:Monika Kumari, Amjad Saifi, Mahmood A. Khan, Vinod Kumar Arora, Yasmeen Shamsi, Sumita Halder, and Rafat Sultana Ahmed Author(s) affiliations:Monika Kumari1, Saifi1, A Khan1, Arora2, Shamsi3, Halder4, Ahmed1 1Department of Biochemistry, University College Medical Sciences GTB Hospital (University Delhi), Delhi, INDIA. 2Department Pathology, 3Department Moalajat, Faculty Medicine...