A5055058370- Tryptophan and brain disorders
- Treatment of Major Depression
- Stress Responses and Cortisol
- HIV/AIDS drug development and treatment
- Cytomegalovirus and herpesvirus research
- Herpesvirus Infections and Treatments
- Long-Term Effects of COVID-19
- Pharmacovigilance and Adverse Drug Reactions
- Epilepsy research and treatment
- Systemic Lupus Erythematosus Research
- Cardiovascular and exercise physiology
- SARS-CoV-2 and COVID-19 Research
- Rheumatoid Arthritis Research and Therapies
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Phytochemicals and Medicinal Plants
- Ergonomics and Musculoskeletal Disorders
- COVID-19 Clinical Research Studies
- Retinopathy of Prematurity Studies
- Toxin Mechanisms and Immunotoxins
- MicroRNA in disease regulation
- Parvovirus B19 Infection Studies
- Neuropeptides and Animal Physiology
University College of Medical Sciences
2015-2025
Guru Teg Bahadur Hospital
2014-2025
Sanofi (United States)
2023-2025
University of Delhi
2012-2024
Visva-Bharati University
2021-2023
Institute of Medical Sciences
2013-2022
Creative Commons
2022
Maulana Azad Medical College
2022
College of Medical Sciences
2022
IBM (United States)
2022
We evaluated the use of urinary anion gap (sodium plus potassium minus chloride) in assessing hyperchloremic metabolic acidosis 38 patients with altered distal acidification and 8 diarrhea. In seven normal subjects given ammonium chloride for three days, was negative (-27±9.8 mmol per liter) pH under 5.3 (4.9±0.03). eight diarrhea also (-20±5.7 liter), even though above (5.64±0.14). contrast, positive all acidification, who were classified as having classic renal tubular (23±4.1 liter, 11...
Valacyclovir exhibits better oral absorption and higher, more prolonged serum concentrations than acyclovir. The efficacy of valacyclovir acyclovir on genital herpes simplex virus (HSV) shedding was assessed in a double-blind, 3-period crossover trial.Sixty-nine immunocompetent participants with HSV-2 received valacyclovir, acyclovir, matching placebo random order for 7-week periods. Participants provided daily mucosal swabs HSV detection by viral culture polymerase chain reaction (PCR).HSV...
<b><i>Background:</i></b> This study evaluated the clinical efficacy of mirtazapine and its effect on serum brain-derived neurotrophic factor (BDNF) tumor necrosis factor-α (TNF-α) levels in patients major-depressive disorder (MDD) with severe depression. <b><i>Methods:</i></b> Patients (aged 18-60) MDD diagnosed by DSM-IV criteria, Hamilton Rating Scale for Depression (HAM-D) score ≥25 were included (n = 30). Mirtazapine was given doses 30...
We previously reported the safety and immunogenicity data from a randomized trial comparing booster responses of vaccinees who received monovalent (MV) recombinant protein Beta-variant (MVB.1.351) MV ancestral (MVD614) vaccines with AS03 adjuvant (Sanofi/GSK) to response mRNA strain BNT162b2 vaccine (Pfizer-BioNTech). First was administered in adult participants primed 2 doses BNT162b2. A subset these available blood samples collected at Day 0 (D0), 28 days (D28), 3 months (M3) post-booster...
Introduction: Telemonitoring and home blood pressure monitoring (HBPM) are becoming popular approaches for managing hypertension. They believed to improve patient compliance as compared the usual care monitoring. This network meta-analysis was undertaken compare (BP) reduction following telemonitoring, HBPM BP approaches. Methods: PubMed clinicaltrial.gov were searched till 15 May 2024 randomized controlled trials (RCTs) comparing in postintervention hypertensive adults. Results: A with 24...
Evidence suggests that neurotrophic factors, inflammatory markers, and circadian rhythm dysfunctions could be involved in pathophysiology of major depressive disorder. This study evaluated the efficacy tolerability agomelatine, a melatonergic drug, fluoxetine (positive comparator) their effect on serum brain-derived factor (BDNF) tumor necrosis (TNF)-α level patients having disorder with severe depression. In present study, we chose TNF-α BDNF because reduction rise levels are linked...
ABSTRACT Members of the Bacteroides fragilis group are among most common anaerobic bacterial isolates in clinical specimens. Metronidazole, a 5-nitroimidazole, is often used as empirical therapy for infections. Susceptibility testing not routinely performed because nearly universal susceptibility spp. to this agent. We report case metronidazole-resistant United States and demonstrate presence nimA gene, encoding nitroreductase previously shown mediate resistance 5-nitroimidazole...
<b>Objective: </b>Good biomarkers are important to guide decisions in the clinical management of rheumatoid arthritis (RA). RA patients harbor antibodies directed against carbamylated proteins which may predict joint damage. This study investigated whether (anti-CarP) serve as surrogate prognostic markers.<br /> <b>Material and methods: </b> Fifty-three with a diagnosis according ACR 1987 criteria were included. Blood samples analyzed for CarP antibody levels...
Despite widespread use of acyclovir, infection with acyclovir-resistant herpes simplex virus type 2 (HSV-2) remains uncommon. To understand the frequency and clinical significance isolates, we evaluated in vitro acyclovir sensitivities sequential isolates from 34 immunocompetent women.HSV-2-seropositive women collected daily samples genital secretions while receiving or placebo, each for 10 weeks. In sensitivity testing was performed using dye uptake assay; which concentration that inhibited...
Combination of disease-modifying antirheumatic drugs (DMARDs) is increasingly used in the treatment rheumatoid arthritis (RA) patients. Hepatotoxicity has been an important safety concern with DMARDs therapy. Though leflunomide (CAS 75706-12-6) emerged as effective oral DMARD, its use associated hepatotoxicity. Limited data available regarding hepatotoxic risk when combination therapy RA An open-label, prospective study was conducted to evaluate after addition other patients, who did not...
Summary 1. Following opioid‐induced antinociception in mice, hyperalgesic responses may be observed. The present study was designed to evaluate the effect of different N ‐methyl‐ d ‐aspartate (NMDA) receptor modulators (magnesium, dextromethorphan, ‐serine) on development morphine‐induced hyperalgesia mice. tail‐flick test used assess effects morphine alone and combination with NMDA modulators. 2. Administration a single low dose (2 mg/kg) mice produced that followed by hyperalgesia. 3....
The objectives of this study were to assess visual and structural outcomes in mycotic keratitis after conventional treatment (topical systemic antifungals) intracameral amphotericin B (ICAMB), evaluate any complications.
Introduction: It is estimated that about 14% of people in India with visual impairment are suffering from refractive errors. The prevalence childhood blindness 0.17% and errors alone the major treatable cause (33.3%) blindness. Assessment Visual acuity should not be only criteria for detection ametropia, as children have strong accomodation. Thus it emphasizing importance refraction testing under cycloplegic drugs. Convergence insufficiency prevalent 7.5% population. Purpose: To study...
Introduction: The American Ophthalmological Association defines CVS as that “complex of eye vision problems related to near work which are experienced during or computer use.” most prevalent ophthalmologic symptoms associated headache, dryness eyes, watering, strain, redness, grittiness, blurring often overlooked but preventable at the same time. According Journal Ophthalmology, 70-75% workers have frequently health problems. We conducted this study assess asthenopic occurring in workers....