A5067131951- Cellular Mechanics and Interactions
- Bone health and osteoporosis research
- 3D Printing in Biomedical Research
- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Force Microscopy Techniques and Applications
- Orthopaedic implants and arthroplasty
- Elasticity and Material Modeling
- Silk-based biomaterials and applications
- Bone health and treatments
- Bone and Joint Diseases
- Microtubule and mitosis dynamics
- Medical Imaging Techniques and Applications
- Medical Imaging and Analysis
- Pluripotent Stem Cells Research
- Nanofabrication and Lithography Techniques
- Tissue Engineering and Regenerative Medicine
- Dental Implant Techniques and Outcomes
- Polymer Surface Interaction Studies
- Cell Image Analysis Techniques
- Mathematical Biology Tumor Growth
- Osteoarthritis Treatment and Mechanisms
- Tendon Structure and Treatment
- Mechanical Behavior of Composites
- Cardiomyopathy and Myosin Studies
Kyoto University
2016-2025
Kyoto University of Education
2021-2024
Japan Agency for Medical Research and Development
2019-2020
Mazda Motor Corporation (Japan)
2002-2019
The University of Tokyo
2004-2018
University of Sheffield
2018
Frontier Medical College
2016-2017
RIKEN
2002-2013
RIKEN Center for Advanced Photonics
2013
In-Q-Tel
2012
Organogenesis is a self-organizing process of multiple cells in three-dimensional (3D) space, where macroscopic tissue deformations are robustly regulated by multicellular autonomy. It clear that this robust regulation requires to sense and modulate 3D formation across different scales, but its underlying mechanisms still unclear. To address question, we developed versatile computational model dynamics at single-cell resolution combined it with the culture system pluripotent stem...
Abstract Formation of oriented myofibrils is a key event in musculoskeletal development. However, the mechanisms that drive myocyte orientation and fusion to control muscle directionality adults remain enigmatic. Here, we demonstrate developing skeleton instructs directional outgrowth skeletal other soft tissues during limb facial morphogenesis zebrafish mouse. Time-lapse live imaging reveals early craniofacial development, myoblasts condense into round clusters corresponding future groups....
A computational simulation method for three-dimensional trabecular surface remodeling was proposed, using voxel finite element models of cancellous bone, and applied to the experimental data. In simulation, microstructure modeled based on digital images, its morphological changes due movement at level were directly expressed by removing/adding elements from/to surface. single under uniaxial compressive loading demonstrated smooth even though trabeculae with discrete elements. Moreover, axis...
Osteocytes play a pivotal role in the regulation of skeletal mass. Osteocyte processes are thought to sense flow interstitial fluid that is driven through osteocyte canaliculi by mechanical stimuli placed upon bone, but how this elicits cellular response virtually unknown. Modern theoretical models assume contain ultrastructural features amplify flow-derived signal. Unfortunately calcified bone matrix has considerably hampered studies on process within its canaliculus. Using one few ultra...
Abstract This study demonstrates computational simulations of multicellular deformation coupled with chemical patterning in the three-dimensional (3D) space. To address these aspects, we proposes a novel mathematical model, where reaction–diffusion system is discretely expressed at single cell level and combined 3D vertex model. investigate complex phenomena emerging from coupling deformation, as an example, employed activator–inhibitor converted activator concentration individual cells into...
Neural tube closure is an important and necessary process during the development of central nervous system. The formation neural structure from a flat sheet epithelium requires several cell morphogenetic events tissue dynamics to account for mechanics deformation. Cell elongation changes cuboidal cells into columnar cells, apical constriction then causes them adopt apically narrow, wedge-like shapes. In addition, plate in Xenopus stratified, non-neural deep layer (deep cells) pull overlying...
The length of long bones is determined by column formation proliferative chondrocytes and subsequent chondrocyte hypertrophy in the growth plate during bone development. Despite importance mechanical loading development, conditions cells within plate, such as stress field, remain unclear owing to difficulty investigating spatiotemporal changes dynamically growing tissues. In this study, mechanisms longitudinal were investigated from a perspective through before secondary ossification center...
Abstract The generation of complex organ structures such as the eye requires intricate orchestration multiple cellular interactions. In this paper, early retinal development is discussed with respect to structure formation optic cup. Although recent studies have elucidated molecular mechanisms differentiation, little known about how unique shape cup determined. A report has demonstrated that optic‐cup morphogenesis spontaneously occurs in three‐dimensional stem‐cell culture without external...
In bone functional adaptation by remodelling, osteocytes in the lacuno-canalicular system are believed to play important roles mechanosensory system. Under dynamic loading, matrix deformation generates an interstitial fluid flow system; this induces shear stress on osteocytic process membrane that is known stimulate osteocytes. sense, behave as mechanosensors and deliver mechanical information neighbouring cells through intercellular communication network. study, remodelling assumed be...