A5103259431- Microbial Metabolism and Applications
- Natural Compound Pharmacology Studies
- Morinda citrifolia extract uses
- Neuropeptides and Animal Physiology
- Liver physiology and pathology
- Bioactive natural compounds
- Neuroinflammation and Neurodegeneration Mechanisms
- Olfactory and Sensory Function Studies
- Mast cells and histamine
- Pharmacological Effects of Natural Compounds
- Flavonoids in Medical Research
- S100 Proteins and Annexins
- Ginseng Biological Effects and Applications
- Liver Disease Diagnosis and Treatment
- Phytochemistry and biological activity of medicinal plants
- Atherosclerosis and Cardiovascular Diseases
- Biological Stains and Phytochemicals
- Traditional Chinese Medicine Analysis
- Chromatography in Natural Products
- Barrier Structure and Function Studies
- Synthesis of Organic Compounds
- Metabolomics and Mass Spectrometry Studies
National Taiwan University
2012-2015
National Research Institute of Chinese Medicine
2012-2015
Ministry of Health and Welfare
2014
National Taiwan University of Science and Technology
2010
Tumor necrosis factor-alpha (TNF-α) is a crucial inflammatory cytokine when hepatocytes are damaged. Glycyrrhiza uralensis Fisch. (Chinese licorice) has been widely used in Chinese herbal prescriptions for the treatment of liver diseases and as food additive. Nuclear factor-kappa B (NF-κB) reporter gene assay TNF-α-induced HepG2 was screening platform. IκBα phosphorylation p65 translocation were measured by Western blotting, nitric oxide (NO) production inducible synthase (iNOS) expression...
Stroke is the second-leading cause of death worldwide, and tissue plasminogen activator (TPA) only drug used for a limited group stroke patients in acute phase. Buyang Huanwu Decoction (BHD), traditional Chinese medicine prescription, has long been improving neurological functional recovery stroke. In this study, we characterized therapeutic effect TPA BHD cerebral ischemia/reperfusion (CIR) injury mouse model using multiplex proteomics approach. After iTRAQ-based analysis, 1310 proteins...
Hypericum sampsonii Hance (Clusiaceae) is a folk medicine used in Taiwan to treat blood stasis, relieve swelling, and as an anti-hepatitis drug. Two new polyprenylated phloroglucinol derivatives, hypersampsone R (1) S (2), known prenylated benzophenone, hyperibone K (3) were isolated from the aerial parts of H. sampsonii. Their structures determined by extensive 1D 2D NMR, MS spectral analyses.