A5090622284- Reconstructive Surgery and Microvascular Techniques
- Body Image and Dysmorphia Studies
- Breast Implant and Reconstruction
- DNA and Nucleic Acid Chemistry
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- DNA Repair Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Facial Rejuvenation and Surgery Techniques
- Genomics and Chromatin Dynamics
- Acute Ischemic Stroke Management
- Cerebral Venous Sinus Thrombosis
- Carcinogens and Genotoxicity Assessment
- Chemical Reaction Mechanisms
- Molecular Biology Techniques and Applications
- Genetic Syndromes and Imprinting
- Tissue Engineering and Regenerative Medicine
- Body Contouring and Surgery
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Intracranial Aneurysms: Treatment and Complications
- Lymphatic System and Diseases
- Genomics, phytochemicals, and oxidative stress
- Hair Growth and Disorders
- Tracheal and airway disorders
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2025
University of Minnesota
2023
Rush University
1983-2022
Philadelphia University
2022
Agilent Technologies (United States)
2015-2016
Hackensack University Medical Center
2016
Northern Westchester Hospital
2000-2015
University at Albany, State University of New York
2015
Agilent Technologies (Germany)
2014
University of Florida
2009-2013
Inter-individual DNA methylation variations were frequently hypothesized to alter individual susceptibility Type 2 Diabetes Mellitus (T2DM). Sequence-influenced methylations described in T2DM-associated genomic regions, but evidence for direct, sequence-independent association with disease risk is missing. Here, we explore disease-contributing through a stepwise study design: first, pool-based, genome-scale screen among 1169 case and control individuals revealed an excess of differentially...
Understanding how the epigenetic blueprint of genome shapes human phenotypes requires systematic evaluation complex interplay between gene activity and different layers epigenome. Utilizing microarray-based techniques, we explored relationships DNA methylation, replication timing expression levels across a variety tissues cell lines. The analyses revealed unequal methylation among early- late-replicating fractions genome: was hypomethylated compared with early-replicating DNA. Moreover,...
Metered dose inhalers (MDIs) are widely used in clinical practice for administering pharmaceuticals targeted to the lung. It is well known that inhalation technique with MDIs can substantially influence response inhaled medications. To determine acceptability of MDI maneuvers, we studied 59 subjects (26 females and 33 males; age, 20 81 yr; mean 38 yr) whether by these individuals complied published recommendations acceptable technique. Measurements were made an adapter contained unobtrusive,...
Common recommendations for cell line authentication, annotation and quality control fall short addressing genetic heterogeneity. Within the Human Toxome Project, we demonstrate that there can be marked cellular phenotypic heterogeneity in a single batch of human breast adenocarcinoma MCF-7 obtained directly from bank are invisible with usual authentication by tandem repeat (STR) markers. STR profiling just fulfills purpose testing, which is to detect significant cross-contamination...
Background: Acellular dermal matrices (ADMs) provide clinical benefits in breast reconstruction but have been associated with increased postoperative complications, most frequently seromas. Fenestration of the ADM before insertion into reconstructed may reduce incidence complications. In this retrospective analysis, complications were assessed after or without fenestrated ADMs. Methods: Patients who underwent immediate 2-staged implant reconstructions using at a single center assessed. The...
Summary: Serotonin syndrome is a condition associated with increased serotonergic transmission in the central nervous system. Although shortfalls diagnostic criteria have led to misleading associations multiple medications, possible precipitant diphenhydramine. Documentation of such an association would prove important for physician practice, as diphenhydramine remains one most popular antihistamines available. We present case 43-year-old woman who developed serotonin after bilateral...
The twenty-first century vision for toxicology involves a transition away from high-dose animal studies to in vitro and computational models (NRC Toxicity testing the 21st century: strategy, National Academies Press, Washington, DC, 2007). This requires mapping pathways of toxicity by understanding how systems respond chemical perturbation. Uncovering transcription factors/signaling networks responsible gene expression patterns is essential defining toxicity, ultimately, determining modes...
Acute mortality for high-risk, or massive, pulmonary embolism (PE) is almost 30% even when treated using advanced therapies. This analysis assessed the safety and effectiveness of mechanical thrombectomy (MT) high-risk PE.
A knowledge of the biochemical basis for UV-induced mutagenesis requires an understanding interaction SOS-activated proteins with DNA polymerase at replication-blocking dipyrimidine lesions. We have suggested previously that presence RecA in this multiprotein complex might be important feature induced because associates preferentially UV-irradiated double-stranded compared to nonirradiated DNA. Previous work by others has indicated (6-4) lesions more mutagenic than common cyclobutane dimer....
The ability to perform abdominal cosmetic surgery in the ambulatory setting provides a more comfortable environment for patient, ease of scheduling physician, and decreased costs. Avoiding use general anesthesia allows quicker recovery, shorter length hospital stay, rate postoperative complications. authors report 106 consecutive abdominoplasties, including fascial plication when indicated, using local anesthesia, with procedural sedation analgesia. All procedures were performed an...
The authors began to use 1-desamino-8-D-arginine vasopressin (DDAVP) Desmopressin Acetate routinely in their facelift patients who had a relatively high risk of bleeding, either from Von Willebrand factor deficiency, platelet dysfunction, aspirin intake, or ease ecchymosis. Based on observations that these enhanced clotting and recovery times, they decided undertake prospective evaluation the effects when administered as preoperative intravenous supplement during cosmetic facioplasty. A...
Transcription factor USF is a ubiquitously expressed member of the helix-loop-helix family proteins. It binds with high affinity to E-box elements and, through interaction coactivators, aids in formation transcription complexes. Previous work demonstrated that regulates genes during erythroid differentiation, including HoxB4 and beta-globin. Here, we show cell-specific expression dominant-negative mutant USF, A-USF, transgenic mice reduces all beta-type globin leads diminished association...
The Human Toxome Project is part of a long-term vision to modernize toxicity testing for the 21st century. In initial phase project, consortium six academic, commercial, and government organizations has partnered map pathways toxicity, using endocrine disruption as model hazard. Experimental data generated at multiple sites, analyzed range computational tools. While effectively gathering, managing, analyzing high-content experiments challenge in its own right, doing so growing number -omics...
The Box-To-X incision and closure is a novel technique for skin-sparing mastectomy with immediate prosthetic reconstruction. portal creates 27% larger access dissection as compared standard periareolar incision, while containing the entire scar within limits of original areola. Following nipple-areolar reconstruction tattooing, virtually scarless results. Over 54-month period, 159 mastectomies using were performed on 98 patients. Allograft slings used in all Successful was achieved 93...
ABSTRACT The human β‐globin genes are regulated by a locus control region (LCR) and expressed at extremely high levels in erythroid cells. How transcriptional fidelity of highly is maintained during the cell cycle not completely understood. Here, we analyzed association transcription factor USF, co‐activator CBP, topoisomerase I (Topo I), basal TFIIB, RNA polymerase II (Pol II) with gene specific cell‐cycle stages. data demonstrate that while Pol globin associated chromatin decreased...
Introduction: Primary reconstruction of the breast is standard care for patients undergoing a mastectomy cancer. Surgical techniques involving immediate implant following skin-sparing can offer improved patient self-image and enhanced aesthetic outcomes compared with other techniques. The use an acellular dermal matrix (ADM) as supporting material has been shown to further improve cosmetic results. Here, we describe technique that allows primary mound after in single procedure using new form...