A5062350477- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Soil Carbon and Nitrogen Dynamics
- Amino Acid Enzymes and Metabolism
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Rice Cultivation and Yield Improvement
- Higher Education Research Studies
- Agronomic Practices and Intercropping Systems
- Agriculture, Soil, Plant Science
- MicroRNA in disease regulation
- Forensic and Genetic Research
- Steroid Chemistry and Biochemistry
- Adenosine and Purinergic Signaling
- Service-Learning and Community Engagement
- Soil and Land Suitability Analysis
- Crop Yield and Soil Fertility
- Plant Micronutrient Interactions and Effects
- Molecular Biology Techniques and Applications
- Genomics, phytochemicals, and oxidative stress
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- Clay minerals and soil interactions
- Circular RNAs in diseases
Indiana University School of Medicine
2019-2024
Indiana University Bloomington
2019-2024
Animal Husbandry and Veterinary Department
2024
Harbin University
2021
Harbin Engineering University
2021
Huazhong Agricultural University
2010-2018
Ministry of Agriculture
2018
Institute of Forensic Science
2018
Lanzhou University
2018
National Chung Cheng University
2007-2016
Abstract Background Platinum based agents—cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, majority OC patients develop recurrent, platinum resistant disease that is uniformly fatal. enriches chemoresistant aldehyde dehydrogenase (ALDH) + stem cells (OCSCs), which contribute to tumor recurrence relapse. Acquired resistance also includes metabolic reprograming switching oxidative phosphorylation (OXPHOS). Chemosensitive...
A straw interlayer added to soil can effectively reduce salinity effects on plant growth, however, the of moisture, salt and microbial community composition growth under a are unclear. rhizobox study was conducted investigate role thickness migration, composition, as well root in sunflower. The included four treatments: Control (no interlayer); S3 (straw 3.0 cm); S5 5.0 S7 7.0 cm). Straw treatments increased moisture by 8.2%-11.0% after irrigation decreased content bud stage 0-40 cm soil....
The majority of women diagnosed with epithelial ovarian cancer eventually develop recurrence, which rapidly evolves into chemoresistant disease. Persistence stem cells (OCSC) at the end therapy may be responsible for emergence resistant tumors. In this study, we demonstrate that in OCSC, tumor suppressor disabled homolog 2-interacting protein (DAB2IP) is silenced by EZH2-mediated H3K27 trimethylation DAB2IP promoter. CRISPR/Cas9-mediated deletion cell lines upregulated expression...
Ovarian cancer is a chemoresponsive tumor with very high initial response rates to standard therapy consisting of platinum/paclitaxel. However, most women eventually develop recurrence, which rapidly evolves into chemoresistant disease. Persistence ovarian stem cells (OCSCs) at the end has been shown contribute resistant tumors. In this study, we demonstrate that long noncoding RNA HOTAIR overexpressed in HGSOC cell lines. Furthermore, expression was upregulated OCSCs compared non-CSC,...
Abstract Soil testing is an important diagnostic tool for assessing crop-available soil potassium (K) and hence making appropriate fertilizer recommendation. This study was aimed at correlating grain yield response data to soil-test K extracted with ammonium acetate (NH 4 OAc), cold nitric acid (HNO 3 ), sodium tetraphenylboron (NaTPB) boiling HNO solution, based on 54 field trials conducted during 2011 2015 across 15 counties in Hubei province, China. The specific objectives were establish...
The persistence of cancer stem cells (CSC) is believed to contribute resistance platinum-based chemotherapy and disease relapse in ovarian cancer, the fifth leading cause cancer-related death among US women. HOXC transcript antisense RNA (HOTAIR) a long, noncoding (lncRNA) overexpressed high-grade serous linked chemoresistance. However, HOTAIR impacts chromatin dynamics CSCs. Oncogenic lncRNA's contributions drug-resistant are incompletely understood. Here, we generated knockout (KO) cell...
In this study, we studied the genetic polymorphisms of short tandem repeat (STR) loci from 13 CODIS and 26 non-CODIS system in Beijing Han population for first time, established a database 39 STR whose forensic parameters were further evaluated. Our results demonstrated no significant deviation Hardy-Weinberg equilibrium pairwise linkage disequilibrium between them. The power discriminations, expected heterozygosity, polymorphic information content, exclusion ranged 0.7740-0.9818,...
Therapeutic targeting of estrogen receptor-α (ERα) by the anti-estrogen tamoxifen is standard care for premenopausal breast cancer patients and remains a key component treatment strategies postmenopausal patients. While significantly increases overall survival, resistance major limitation despite continued expression ERα in resistant tumors. Previous reports have described increased oxidative stress versus sensitive role PARP1 mediating damage repair. We hypothesized that activity mediated...
Long seen as adaptive, responsive, and flexible higher education institutions in the face of educational, economic, social changes, American community college model has been adapted many parts world. However, extent to which could be successfully implemented depends on political, socioeconomic contexts each country. Therefore, better understand how by other countries requires critical analysis these systems case case. This article aims critically analyze models are countries, particularly...
Y chromosome Short tandem repeats (Y-STRs) analysis has been widely used in forensic identification, kinship testing, and population evolution. An accurate understanding of haplotype mutation rate will benefit these applications. In this work, we analyzed 1123 male samples from Northern Chinese Han which including 578 DNA-confirmed father-son pairs at 22 Y-STRs loci. A total 537 haplotypes were observed the overall diversity was calculated as 1.0000 ± 0.0001. Except that only two twice, all...
This article begins by reviewing the development of community education in two-year colleges. It focuses on five major types programs: adult education, continuing lifelong learning, services, and especially community-based education. The concludes discussing challenges programs face due to conflicting missions college, it provides suggestions for research practice.
Overestimation of nitrogen (N) uptake requirement is one the driving forces overuse N fertilization and low efficiency use in China. In this study, we collected data from 1 844 site-years rice (Oryza sativa L.) under various rotation cropping systems across Yangtze River Valley. Selected treatments included without (N0 treatment) with application (N which were recommended by local technicians, a wide grain range 1.5–11.9 t ha−1. Across site-years, over 96% sites showed yield increase...
<title>Abstract</title> The degradable film can solve the problem that traditional plastic is difficult to recycle and heavy pollution for a long time. effects of degraded mulching on microbial diversity are significant. However, responses relevant communities in different ecological niches (e.g., bulk soil, rhizosphere endosphere) sunflower roots poorly understood. This study analyzed plastics bacterial fungal diversities, community assembly process, key dominant species roots. results...
<p>Supplementary Figure 3</p>