Daniel W. Nascimento

ORCID: 0000-0001-5321-4166
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About
Contact & Profiles
Research Areas
  • Cell Adhesion Molecules Research
  • Erythrocyte Function and Pathophysiology
  • Immune Response and Inflammation
  • Bone Metabolism and Diseases
  • Immune cells in cancer
  • Cellular Mechanics and Interactions
  • Neutrophil, Myeloperoxidase and Oxidative Mechanisms
  • Bone and Dental Protein Studies

Cleveland Clinic Lerner College of Medicine
2021-2022

The cellular and molecular mechanisms of bone development homeostasis are clinically important, but not fully understood. Mutations in integrins Kindlin3 humans known as Leukocyte adhesion deficiencies (LAD) cause a wide spectrum complications, including osteopetrosis. Yet, the rarity, frequent misdiagnosis, lethality LAD preclude mechanistic analysis skeletal abnormalities these patients. Here, using inducible constitutive tissue-specific knockout (K3KO) mice, we show that lack...

10.1016/j.bone.2022.116397 article EN cc-by-nc-nd Bone 2022-03-25
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