A5067073731- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neural Engineering
- Neurogenesis and neuroplasticity mechanisms
- Neurobiology and Insect Physiology Research
- Immune cells in cancer
- Vestibular and auditory disorders
- Noise Effects and Management
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- Hearing Loss and Rehabilitation
- Advanced Memory and Neural Computing
- Cellular transport and secretion
Stanford University
2018-2022
University of Southern California
2010-2018
Hematopoietic cell transplantation after myeloablative conditioning has been used to treat various genetic metabolic syndromes but is largely ineffective in diseases affecting the brain presumably due poor and variable myeloid incorporation into central nervous system. Here, we developed characterized a near-complete homogeneous replacement of microglia with bone marrow cells mice without need for manipulation donor or host. The high chimerism resulted from competitive advantage scarce...
Abstract Sparse representation is considered an important coding strategy for cortical processing in various sensory modalities. It remains unclear how sparseness arises and being regulated. Here, unbiased recordings from primary auditory cortex of awake adult mice revealed salient layer (L)2/3, with a majority excitatory neurons exhibiting no increased spiking response to each sound types tested. was not observed parvalbumin (PV) inhibitory neurons. The nonresponding did receive...
Intensity defines one fundamental aspect of sensory information and is specifically represented in each modality. Interestingly, only the central auditory system are intensity-selective neurons evolved. These characterized by nonmonotonic response-level functions. The synaptic circuitry mechanisms underlying generation intensity selectivity from nonselective nerve inputs remain largely unclear. Here, we performed vivo whole-cell recordings pyramidal rat dorsal cochlear nucleus (DCN), where...
In central auditory pathways, neurons exhibit a great diversity of temporal discharge patterns, which may contribute to the parallel processing signals. How such response emerges in circuits remains unclear. Here, we investigated whether synaptic mechanisms can generation at first stage along neuraxis. By vivo whole-cell voltage-clamp recording dorsal cochlear nucleus rats, revealed excitatory and inhibitory inputs underlying three different firing patterns fusiform/pyramidal stimuli:...
Abstract Oligodendrocytes in the central nervous system (CNS) produce myelin sheaths that insulate axons to facilitate efficient electrical conduction. These contain lamellar microtubules enable vesicular transport into inner sheath. Mechanistically, oligodendrocytes rely on Golgi outpost organelles and associated protein tubulin polymerization promoting (TPPP) nucleate or form new outside of cell body. Consequently, elongation is defective Tppp knock-out (KO) mice, which have thinner...