A5034238743- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neuroscience and Neural Engineering
- Neuroscience and Neuropharmacology Research
- Molecular Communication and Nanonetworks
- CCD and CMOS Imaging Sensors
- Optical Imaging and Spectroscopy Techniques
- Memory and Neural Mechanisms
- Neurological disorders and treatments
- EEG and Brain-Computer Interfaces
- Image and Signal Denoising Methods
- Neuroinflammation and Neurodegeneration Mechanisms
- History of Medical Practice
- Neural and Behavioral Psychology Studies
- Cell Image Analysis Techniques
- Cellular transport and secretion
- Medical History and Innovations
- History of Medicine Studies
- Genetic Neurodegenerative Diseases
University of California, Los Angeles
2023-2025
Olive View-UCLA Medical Center
2023
UCLA Medical Center
2023
California Institute of Technology
2023
Stanford University
2016-2018
Abstract Understanding how brain activity is related to animal behavior requires measuring multi-area interactions on multiple timescales. However, methods perform chronic, simultaneous recordings of neural from many areas are lacking. Here, we introduce a novel approach for independent chronic probe implantation that enables flexible, interrogation regions during head restrained or freely moving behavior. The approach, called indie ( in dependent d ovetail implants e lectrophysiology),...
Electrophysiology has proven invaluable to record neural activity, and the development of Neuropixels probes dramatically increased number recorded neurons. These are often implanted acutely, but acute recordings cannot be performed in freely moving animals neurons tracked across days. To study key behaviors such as navigation, learning, memory formation, must chronically. An ideal chronic implant should (1) allow stable for weeks; (2) reuse after explantation; (3) light enough use mice....
Electrophysiology has proven invaluable to record neural activity, and the development of Neuropixels probes dramatically increased number recorded neurons. These are often implanted acutely, but acute recordings cannot be performed in freely moving animals neurons tracked across days. To study key behaviors such as navigation, learning, memory formation, must chronically. An ideal chronic implant should (1) allow stable for weeks; (2) reuse after explantation; (3) light enough use mice....
Abstract Electrophysiology has proven invaluable to record neural activity, and the development of Neuropixels probes dramatically increased number recorded neurons. These are often implanted acutely, but acute recordings cannot be performed in freely moving animals neurons tracked across days. To study key behaviors such as navigation, learning, memory formation, must chronically. An ideal chronic implant should (1) allow stable for weeks; (2) reuse after explantation; (3) light enough use...
Electrophysiology has proven invaluable to record neural activity, and the development of Neuropixels probes dramatically increased number recorded neurons. These are often implanted acutely, but acute recordings cannot be performed in freely moving animals neurons tracked across days. To study key behaviors such as navigation, learning, memory formation, must chronically. An ideal chronic implant should (1) allow stable for weeks; (2) reuse after explantation; (3) light enough use mice....
Existing work demonstrates that animals alternate between engaged and disengaged states during perceptual decision-making. To understand the neural signature of these states, we performed cortex-wide measurements activity in mice making auditory decisions. The trial-averaged magnitude was similar two states. However, trial-to-trial variance higher disengagement. this increased variance, trained separate linear encoding models on data from each state. demonstrated although task variables...
Electrophysiology has proven invaluable to record neural activity, and the development of Neuropixels probes dramatically increased number recorded neurons. These are often implanted acutely, but acute recordings cannot be performed in freely moving animals neurons tracked across days. To study key behaviors such as navigation, learning, memory formation, must chronically. An ideal chronic implant should (1) allow stable for weeks; (2) reuse after explantation; (3) light enough use mice....
High-density microelectrode arrays (MEAs) have opened new possibilities for systems neuroscience in human and non-human animals, but brain tissue motion relative to the array poses a challenge downstream analyses, particularly recordings. We introduce DREDge (Decentralized Registration of Electrophysiology Data), robust algorithm which is well suited registration noisy, nonstationary extracellular electrophysiology In addition estimating from spikes action potential (AP) frequency band,...
Hippocampal spiking sequences encode and link behavioral information across time. How inhibition sculpts these remains unknown. We performed longitudinal voltage imaging of CA1 parvalbumin- somatostatin-expressing interneurons in mice during an odor-cued working memory task, before after training. During this pyramidal odor-specific the cue throughout a delay period. In contrast, most encoded odor delivery, but not identity, nor Population was stable days, with constant field turnover,...