A5023772329- Neural dynamics and brain function
- Advanced Fluorescence Microscopy Techniques
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- EEG and Brain-Computer Interfaces
- Cell Image Analysis Techniques
- Neuroscience and Neural Engineering
- Optical Imaging and Spectroscopy Techniques
- Pain Mechanisms and Treatments
- Peripheral Nerve Disorders
- Pulmonary Hypertension Research and Treatments
- Neurological disorders and treatments
- Vascular anomalies and interventions
- Molecular Biology Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Intraoperative Neuromonitoring and Anesthetic Effects
- Advanced Biosensing Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Transcranial Magnetic Stimulation Studies
- Glycosylation and Glycoproteins Research
University of Florida
2025
University of California, Los Angeles
2024
Cold Spring Harbor Laboratory
2020-2023
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2022
Hofstra University
2020-2021
Lenox Hill Hospital
2021
Neurological Surgery
2021
Princeton University
2012-2014
Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Recent efforts in protein engineering have significantly increased the performance of GECIs. The state-of-the art single-wavelength GECI, GCaMP3, has been deployed a number model organisms and can reliably detect three or more action potentials short bursts several vivo . Through structure determination, targeted mutagenesis, high-throughput screening, battery vitro assays, we dynamic range GCaMP3 by...
A major goal of the BRAIN Initiative is development technologies to monitor neuronal network activity during active information processing. Toward this goal, genetically encoded calcium indicator proteins have become widely used for reporting in preparations ranging from invertebrates awake mammals. However, slow response times, narrow sensitivity range Ca2+ and some cases, poor signal-to-noise ratio still limit their usefulness. Here, we review recent improvements field neural...
Abstract Understanding how cortical circuits generate complex behavior requires investigating the cell types that comprise them. Functional differences across pyramidal neuron (PyN) have been observed within areas, but it is not known whether these local extend throughout cortex, nor additional emerge when larger-scale dynamics are considered. We used genetic and retrograde labeling to target tract, intratelencephalic corticostriatal projection neurons measured their cortex-wide activity....
Abstract Motivation Targeted enrichment via capture probes, also known as baits, is a promising complementary procedure for next-generation sequencing methods. This technique employs short biotinylated oligonucleotide probes that hybridize with genetic material in sample. Following hybridization, the target fragments can be easily isolated and processed minimal contamination from irrelevant material. Designing an efficient set of baits sequences, however, NP-hard problem. Results We develop...
Abstract Understanding how cortical circuits generate complex behavior requires investigating the cell types that comprise them. Functional differences across pyramidal neuron (PyN) have been observed within areas, but it is not known whether these local extend throughout cortex, nor additional emerge when larger-scale dynamics are considered. We used genetic and retrograde labeling to target tract (PT), intratelencephalic (IT) corticostriatal projection neurons measured their cortex-wide...
Motivation: Precise and personalized targeting for MR-guided focused ultrasound (MRgFUS) is desired to ensure treatment efficacy avoid side effect. Goal(s): To assess THalamus Optimized Multi Atlas Segmentation (THOMAS) on white-matter nulled MRI of the ventral intermediate (VIM) thalamic nucleus in MRgFUS tremor patients. Approach: We retrospectively assessed relationships standard indirectly targeted coordinates, post-FUS lesions, THOMAS segmentation with effects scores patients who...
Measurements of neuronal activity across brain areas are important for understanding the neural correlates cognitive and motor processes like attention, decision-making, action selection. However, techniques that allow cellular resolution measurements expensive require a high degree technical expertise, which limits their broad use. Widefield imaging genetically encoded indicators is throughput, cost effective, flexible approach to measure specific cell populations with temporal cortex-wide...