A5009836175- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Neural and Behavioral Psychology Studies
- Advanced Memory and Neural Computing
- Visual perception and processing mechanisms
- Muscle activation and electromyography studies
- Motor Control and Adaptation
- Photoreceptor and optogenetics research
- Cryospheric studies and observations
- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- Neural Networks and Applications
- Robotic Locomotion and Control
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Neural Networks and Reservoir Computing
- Functional Brain Connectivity Studies
- Robotics and Sensor-Based Localization
- Underwater Vehicles and Communication Systems
- Soil Mechanics and Vehicle Dynamics
- Cell Image Analysis Techniques
- Image and Signal Denoising Methods
- Retinal Development and Disorders
- Plant Surface Properties and Treatments
- Neuroscience and Neuropharmacology Research
Columbia University
2021-2025
Brain (Germany)
2023-2024
Howard Hughes Medical Institute
2017-2024
McGovern Institute for Brain Research
2024
Massachusetts Institute of Technology
2024
Neurological Surgery
2024
University of California, Davis
2024
Columbia University Irving Medical Center
2021-2023
Neurosciences Institute
2020-2022
Stanford University
2012-2022
Abstract In many experiments, neuroscientists tightly control behavior, record trials, and obtain trial-averaged firing rates from hundreds of neurons in circuits containing billions behaviorally relevant neurons. Di-mensionality reduction methods reveal a striking simplicity underlying such multi-neuronal data: they can be reduced to low-dimensional space, the resulting neural trajectories this space yield remarkably insightful dynamical portrait circuit computation. This raises profound...
The brain makes decisions by accumulating evidence until there is enough to stop and choose. Neural mechanisms of accumulation are established in association cortex, but the site mechanism termination unknown. Here, we show that superior colliculus (SC) plays a causal role terminating decisions, provide for which this occurs. We recorded simultaneously from neurons lateral intraparietal area (LIP) SC while monkeys made perceptual decisions. Despite similar trial-averaged activity, found...
Abstract High-density, integrated silicon electrodes have begun to transform systems neuroscience, by enabling large-scale neural population recordings with single cell resolution. Existing technologies, however, provided limited functionality in nonhuman primate species such as macaques, which offer close models of human cognition and behavior. Here, we report the design, fabrication, performance Neuropixels 1.0-NHP, a high channel count linear electrode array designed enable simultaneous...
Abstract Calcium imaging is a powerful tool for recording from large populations of neurons in vivo. Imaging rhesus macaque motor cortex can enable the discovery fundamental principles cortical function and inform design next generation brain-computer interfaces (BCIs). Surface two-photon imaging, however, cannot presently access somatic calcium signals all layers due to photon scattering. Here, we demonstrate an implant system capable chronic, motion-stabilized neuronal macaques engaged...
Neuroscience is experiencing a data revolution in which simultaneous recording of many hundreds or thousands neurons revealing structure population activity that not apparent from single-neuron responses. This typically extracted trial-averaged data. Single-trial analyses are challenging due to incomplete sampling the neural population, trial-to-trial variability, and fluctuations action potential timing. Here we introduce Latent Factor Analysis via Dynamical Systems (LFADS), deep learning...
Abstract The rich repertoire of skilled mammalian behavior is the product neural circuits that generate robust and flexible patterns activity distributed across populations neurons. Decades associative studies have linked many behaviors to specific population activity, but association alone cannot reveal dynamical mechanisms shape those patterns. Are local high-dimensional reservoirs able arbitrary superpositions with appropriate excitation? Or might circuit dynamics be shaped in response...
We review recent progress in neural probes for brain recording, with a focus on the Neuropixels platform. Historically number of neurons' recorded simultaneously, follows Moore's law like behavior, numbers doubling every 6.7 years. Using traditional techniques probe fabrication, continuing to scale up electrode densities is very challenging. describe custom CMOS process technology that enables counts well beyond 1000 electrodes; aim characterize large populations single neuron spatial...
The National Science Foundation operates stations on the ice sheets of Antarctica and Greenland to investigate Earth's climate history, life in extreme environments, evolution cosmos. Understandably, logistics costs predominate budgets due remote locations harsh environments involved. Currently, manual ground‐penetrating radar (GPR) surveys must preceed vehicle travel across polar detect subsurface crevasses or other voids. This exposes crew risks undetected hazards. We have developed an...
Neurobiological investigations of perceptual decision-making have furnished the first glimpse a flexible cognitive process at level single neurons ( Shadlen and Newsome, 1996 ; Kiani, 2013 ). Neurons in parietal prefrontal cortex Kim Shadlen, 1999 Romo et al., 2004 Hernández 2002; Ding Gold, 2012 ) are thought to represent accumulation noisy evidence, acquired over time, leading decision. Neural recordings averaged many decisions provided support for deterministic rise activity termination...
High-density electrophysiology probes have opened new possibilities for systems neuroscience in human and non-human animals, but probe motion poses a challenge downstream analyses, particularly recordings. We improve on the state of art tracking this with four major contributions. First, we extend previous decentralized methods to use multiband information, leveraging local field potential (LFP) addition spikes. Second, show that LFP-based approach enables registration at sub-second temporal...
Neurobiological investigations of perceptual decision-making have furnished the first glimpse a flexible cognitive process at level single neurons. Neurons in parietal and prefrontal cortex are thought to represent accumulation noisy evidence, acquired over time, leading decision. Neural recordings averaged many decisions provided support for deterministic rise activity termination bound. Critically, it is unobserved stochastic component that confer variability both choice decision time....
Epidermal electrophysiology is a non-invasive method used in research and clinical practices to study the electrical activity of brain, heart, nerves, muscles. However, electrode/tissue interlayer materials such as ionically conducting pastes can negatively affect recordings by introducing lateral electrode-to-electrode ionic crosstalk reducing spatial resolution. To overcome this issue, biocompatible, anisotropic-conducting composites (ACI) that establish an electrically anisotropic...
Neurobiological investigations of perceptual decision-making have furnished the first glimpse a flexible cognitive process at level single neurons. Neurons in parietal and prefrontal cortex are thought to represent accumulation noisy evidence, acquired over time, leading decision. Neural recordings averaged many decisions provided support for deterministic rise activity termination bound. Critically, it is unobserved stochastic component that confer variability both choice decision time....
Summary Voluntary movement requires communication from cortex to the spinal cord, where a dedicated pool of motor units (MUs) activates each muscle. The canonical description MU function rests upon two foundational tenets. First, cannot control MUs independently but supplies with common drive. Second, are recruited in rigid fashion that largely accords Henneman’s size principle. While this paradigm has considerable empirical support, direct test simultaneous observations many across diverse...