A5002021083- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- Neural dynamics and brain function
- CCD and CMOS Imaging Sensors
- Analog and Mixed-Signal Circuit Design
- Superconducting and THz Device Technology
- Radiation Effects in Electronics
- Particle Detector Development and Performance
- Nuclear reactor physics and engineering
- EEG and Brain-Computer Interfaces
- Advancements in Semiconductor Devices and Circuit Design
- Photoreceptor and optogenetics research
- Advanced Semiconductor Detectors and Materials
- Nuclear Materials and Properties
- Integrated Circuits and Semiconductor Failure Analysis
- Silicon and Solar Cell Technologies
- Parallel Computing and Optimization Techniques
- Nuclear and radioactivity studies
- Physics of Superconductivity and Magnetism
- Semiconductor materials and devices
- Atomic and Subatomic Physics Research
- Infrared Target Detection Methodologies
- Embedded Systems Design Techniques
- Nuclear Engineering Thermal-Hydraulics
- Photocathodes and Microchannel Plates
IMEC
2016-2025
Imec the Netherlands
2016
KU Leuven
2010
Joint Research Centre
1970
The Photodetector Array Camera and Spectrometer (PACS) is one of the three science instruments on ESA's far infrared submillimetre observatory. It employs two Ge:Ga photoconductor arrays (stressed unstressed) with 16x25 pixels, each, filled silicon bolometer 16x32 32x64 respectively, to perform integral-field spectroscopy imaging photometry in 60-210μ m wavelength regime. In mode, it simultaneously images bands, 60-85μ or 85-125μ\m 125-210μ m, over a field view ~1.75'x3.5', close Nyquist...
Measuring the dynamics of neural processing across time scales requires following spiking thousands individual neurons over milliseconds and months. To address this need, we introduce Neuropixels 2.0 probe together with newly designed analysis algorithms. The has more than 5000 sites is miniaturized to facilitate chronic implants in small mammals recording during unrestrained behavior. High-quality recordings long were reliably obtained mice rats six laboratories. Improved site density...
In vivo recording of neural action-potential and local-field-potential signals requires the use high-resolution penetrating probes. Several international initiatives to better understand brain are driving technology efforts towards maximizing number sites while minimizing probe dimensions. We designed fabricated (0.13- μm SOI Al CMOS) a 384-channel configurable for large-scale in signals. Up 966 selectable active electrodes were integrated along an implantable shank (70 wide, 10 mm long, 20...
Abstract High-density, integrated silicon electrodes have begun to transform systems neuroscience, by enabling large-scale neural population recordings with single cell resolution. Existing technologies, however, provided limited functionality in nonhuman primate species such as macaques, which offer close models of human cognition and behavior. Here, we report the design, fabrication, performance Neuropixels 1.0-NHP, a high channel count linear electrode array designed enable simultaneous...
High-resolution extracellular electrophysiology is the gold standard for recording spikes from distributed neural populations, and especially powerful when combined with optogenetics manipulation of specific cell types high temporal resolution. We integrated these approaches into prototype Neuropixels Opto probes, which combine electronic photonic circuits. These devices pack 960 electrical sites two sets 14 light emitters onto a 1 cm shank, allowing spatially addressable optogenetic...
We present a high electrode density and channel count CMOS (complementary metal-oxide-semiconductor) active neural probe containing 1344 neuron sized recording pixels (20 µm × 20 µm) 12 reference 80 µm), densely packed on 50 thick, 100 wide, 8 mm long shank. The electrodes or consist of dedicated in-situ circuits for signal source amplification, which are directly located under each electrode. supports the simultaneous all 1356 with sufficient to noise ratio typical neuroscience...
Abstract To study the dynamics of neural processing across timescales, we require ability to follow spiking thousands individually separable neurons over weeks and months, during unrestrained behavior. address this need, introduce Neuropixels 2.0 probe together with novel analysis algorithms. The new has 5,000 sites is miniaturized such that two probes plus a headstage, recording 768 at once, weigh just 1 g, suitable for implanting chronically in small mammals. Recordings high quality...
Multi-electrode arrays (MEAs) are a candidate technology to screen cardiotoxicity <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in vitro</i> because they enable noninvasive recording of cardiac beating rate, electrical field potential duration, and other parameters. In this paper, we present an active MEA chip featuring 16 384 electrodes, 1024 simultaneous readout channels, 64 stimulation units (SUs) six different cell-interfacing...
Large-scale <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in vivo</i> electrophysiology requires tools that enable simultaneous recording of multiple brain regions at single-neuron level. This calls for the design more compact neural probes offer even larger arrays addressable sites and high channel counts. With this aim, we present in paper a quad-shank approach to integrate as many 5,120 on single probe. Compact fully-differential...
Multi-electrode arrays, both active or passive, emerged as ideal technologies to unveil intricated electrophysiological dynamics of cells and tissues. Active MEAs, designed using complementary metal oxide semiconductor technology (CMOS), stand over passive devices thanks the possibility achieving single-cell resolution, reduced electrode size, crosstalk higher functionality portability. Nevertheless, most reported CMOS MEA systems mainly rely on a single operational modality, which strongly...
Although CMOS fabrication has enabled a quick evolution in the design of high-density neural probes and neural-recording chips, scaling miniaturization complete data-acquisition systems happened at slower pace. This is mainly due to complexity many requirements that change depending on specific experimental settings. In essence, fundamental challenge system getting signals describing largest possible set neurons out brain down data storage for analysis. requires optimization considers...
In vivo recording of neural action-potential (AP) and local-field-potential (LFP) signals requires the use high-resolution penetrating probes. Driven by need for large-scale minimal tissue damage, a technology roadmap has been defined next-generation probes aiming to maximize number sites while minimizing probe dimensions [1]. this paper we present 384-channel configurable active high-density which implements in situ buffering under each electrode minimize crosstalk between adjacent metal...
The current demand for high-channel-count neural-recording interfaces calls more area- and power-efficient readout architectures that do not compromise other electrical performances. In this article, we present a miniature 128-channel neural recording integrated circuit (NRIC) the simultaneous acquisition of local field potentials (LFPs) action (APs), which can achieve very good between area, power, noise, input range, electrode dc offset (EDO) cancellation. An ac-coupled 1st-order...
We present a high density CMOS neural probe with active electrodes (pixels), consisting of dedicated in-situ circuits for signal source amplification. The complete contains 1356 neuron sized (20×20 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) pixels densely packed on 50 thick, 100 wide and 8 mm long shank. It allows simultaneous high-performance recording from 678 possibility to simultaneously observe all the increased noise....
We review recent progress in neural probes for brain recording, with a focus on the Neuropixels platform. Historically number of neurons' recorded simultaneously, follows Moore's law like behavior, numbers doubling every 6.7 years. Using traditional techniques probe fabrication, continuing to scale up electrode densities is very challenging. describe custom CMOS process technology that enables counts well beyond 1000 electrodes; aim characterize large populations single neuron spatial...
Patch clamp is currently the gold standard for studying cell electrophysiology in preclinical drug discovery. Since it a time-consuming technique, passive and active multielectrode arrays (MEAs) have been introduced increased throughput extracellular (ExC) vitro measurements [1-3]. However, most of these tools cannot capture essential features intracellular (InC) action potentials (APs) used toxicity. It has shown that InC access can be achieved by highly localized electroporation [4], which...
In this paper, we present a miniature 128-channel neural recording IC (NRIC) for the simultaneous acquisition of local field potentials (LFPs) and action (APs). An AC-coupled 1 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">st</sup> -order Δ-ΔΣ architecture is proposed to achieve rail-to-rail electrode DC offset rejection, low power small area, while providing noise larger input range compared other designs. This digitally-intensive leverages...
Abstract It is an uninformative truism to state that the brain operates at multiple spatial and temporal scales, each with own set of emergent phenomena. More worthy attention point our current understanding it cannot clearly indicate which these phenomenological scales are significant contributors brain’s function primary output (i.e. behaviour). Apart from sheer complexity problem, a major contributing factor this affairs lack instrumentation can simultaneously address without causing...
We present the development of a monolithically integrated CMOS and photonics platform, capable supporting passive active visible with thermooptic switches. This platform is co-integrated 130-nm SOI-based 6-level Al-BEOL, enabling range bi-modal opto-electronic sensor applications. Through this we demonstrate an implantable CMOS-based neural probe that integrates high-density array 960 selectable electrodes 384 recording channels, along 14 programmable optical emission sites for two...
Recording neural activity from freely behaving animals has become extremely important for basic research in neuroscience. One of the major limitations this domain arises need a low-power, lightweight, wireless recording unit that can be used on small at least couple hours. To conserve power, it is essential to reduce large data volume tens or even hundreds sites. Since widely considered primary information limited infrequent action potentials (AP spike), considerably reduced by using system...
We present the first measurement results from hybrid AlGaN-on-Si-based Extreme Ultraviolet (EUV) imagers with 10 µm pixel-to-pixel pitch. The 256×256 backside illuminated Focal Plane Arrays (FPAs) were hybridized to dedicated Si-based CMOS Readouts (ROICs). AlGaN active layer 40% Al concentration provides an intrinsic rejection of wavelengths larger than 280 nm (solar blindness), together enhanced radiation hardness (1). Sensitivity in Deep UV (DUV), Far (FUV) and was verified using...