A5075663080- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Neuroscience and Neuropharmacology Research
- Neurobiology and Insect Physiology Research
- Neuroscience and Neural Engineering
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Olfactory and Sensory Function Studies
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Spine and Intervertebral Disc Pathology
- CCD and CMOS Imaging Sensors
- Musculoskeletal pain and rehabilitation
- Image Processing Techniques and Applications
- Cellular transport and secretion
- Cultural Insights and Digital Impacts
- Multisensory perception and integration
- Power Line Communications and Noise
- Neural Networks and Applications
- EEG and Brain-Computer Interfaces
- Genetics and Neurodevelopmental Disorders
- Electromagnetic Compatibility and Measurements
Neuroelectronics Research Flanders
2017-2024
KU Leuven
2005-2024
IMEC
2017-2024
VIB-KU Leuven Center for Brain & Disease Research
2017-2024
Allen Institute for Brain Science
2023
VIB-KU Leuven Center for Microbiology
2018-2022
Vlaams Instituut voor Biotechnologie
2017-2018
Harvard University
2009-2016
Beth Israel Deaconess Medical Center
2013
Smith-Kettlewell Eye Research Institute
2003-2010
Many thousands of cortical neurons are activated by any single sensory stimulus, but the organization these populations is poorly understood. For example, in mouse visual cortex—whose preferred orientations arranged randomly—organized with respect to other response properties? Using high-speed vivo two-photon calcium imaging, we characterized receptive fields up 100 excitatory and inhibitory a 200 μm imaged plane. Inhibitory had nonlinearly summating, complex-like were weakly tuned for...
Sparse orthogonal coding is a key feature of hippocampal neural activity, which believed to increase episodic memory capacity and assist in navigation. Some retrosplenial cortex (RSC) neurons convey distributed spatial navigational signals, but place-field representations such as observed the hippocampus have not been reported. Combining cellular Ca2+ imaging RSC mice with head-fixed locomotion assay, we identified population neurons, located predominantly superficial layers, whose ensemble...
How neural circuits develop in the human brain has remained almost impossible to study at neuronal level. Here, we investigate cortical neuron development, plasticity, and function using a mouse/human chimera model which xenotransplanted pyramidal neurons integrate as single cells into mouse cortex. Combined tracing, electrophysiology, vivo structural functional imaging of transplanted reveal coordinated developmental roadmap recapitulating key milestones development. The display prolonged...
Dysfunctions of network activity and functional connectivity (FC) represent early events in Alzheimer's disease (AD), but the underlying mechanisms remain unclear. Astrocytes regulate local neuronal healthy brain, their involvement hyperactivity AD is unknown. We show increased FC human cingulate cortex several years before amyloid deposition. find same disruption AppNL-F mice. Crucially, these disruptions are accompanied by decreased astrocyte calcium signaling. Recovery astrocytic...
The responses of neurons in lateral geniculate nucleus (LGN) exhibit powerful suppressive phenomena such as contrast saturation, size tuning, and masking. These cannot be explained by the classical center-surround receptive field have been ascribed to a variety mechanisms, including feedback from cortex. We asked whether these might all single mechanism, gain control, which is inherited retina possibly strengthened thalamus. formalized an intuitive model retinal control that explicitly...
Retrosplenial cortex (RSC) is involved in visuospatial integration and spatial learning, RSC neurons exhibit discrete, place cell-like sequential activity that resembles the population code of space hippocampus. To investigate origins dynamics this activity, we combined longitudinal cellular calcium imaging dysgranular mice with excitotoxic hippocampal lesions. We tracked emergence stability over consecutive sessions. Overall, was experience-dependent, emerging gradually time, but, as seen...
Human brain ontogeny is characterized by a considerably prolonged neotenic development of cortical neurons and circuits. Neoteny thought to be essential for the acquisition advanced cognitive functions, which are typically altered in intellectual disability (ID) autism spectrum disorders (ASDs). neuronal neoteny could disrupted some forms ID and/or ASDs, but this has never been tested. Here, we use xenotransplantation human into mouse model SYNGAP1 haploinsufficiency, one most prevalent...
Abstract The visual system is composed of diverse cell types that encode distinct aspects the scene and may form separate processing channels. Here we present further evidence for hypothesis whereby functional groups in dorsal lateral geniculate nucleus (dLGN) are differentially modulated during behavior. Using simultaneous multi-electrode recordings dLGN primary cortex (V1) behaving mice, characterized impact locomotor activity on response amplitude, variability, correlation spatiotemporal...
The cerebral cortex contains diverse neural representations of the visual scene, each enabling distinct and spatial abilities. However, extent to which are distributed or segregated across cortical areas remains poorly understood. By determining temporal responses >30,000 layer 2/3 pyramidal neurons, we characterize functional organization parallel streams eight mouse cortex. While dorsal ventral form complementary spatiotemporal frequency, motion speed, patterns, anterior posterior show...
Dendritic architecture plays a crucial role in shaping how neurons extract behaviorally relevant information from sensory inputs. Wide-field the superior colliculus integrate visual retina to encode cues critical for visually guided orienting behaviors. However, principles governing these filter their inputs generate appropriate responses remain unclear. Using viral tracing, two-photon calcium imaging, and computational modeling, we show that wide-field receive functionally diverse twelve...
Intracortical electrical stimulation has emerged as a promising approach for sensory restoration, such cortical visual prosthesis, yet its effectiveness is limited by current spread and electrode density constraints. To determine whether intracortical bipolar steering, via modulation of the return position, can enhance neural activation selectivity compared to traditional monopolar stimulation, with aim improving spatial precision in restoration. We applied used two-photon calcium imaging on...
In the early visual system, a contrast gain control mechanism sets of responses based on locally prevalent contrast. The measure used by this adaptation is commonly assumed to be standard deviation light intensities relative mean (root-mean-square contrast). A number alternatives, however, are possible. For example, might depend absolute deviations mean, or prevalence darkest lightest intensities. We investigated statistical computation underlying in cat9s lateral geniculate nucleus, which...
Silicon neuroprobes hold great potential for studies of large-scale neural activity and brain computer interfaces, but data on response in chronic implants is limited. Here we explored with vivo cellular imaging the to multisite silicon probes recordings. We tested a implant mice consisting CMOS-compatible probe rigidly implanted cortex under cranial window. Multiunit recordings cortical neurons showed no degradation electrophysiological signals weeks after implantation (mean spike noise...
The posterior parietal cortex (PPC) contributes to multisensory and sensory-motor integration, as well spatial navigation. Based on primate studies, the PPC is composed of several subdivisions with differing connection patterns, including areas that exhibit retinotopy. In mice composition still under debate. We propose a revised anatomical delineation in which we classify higher order visual rostrolateral area (RL), anteromedial (AM), Medio-Medial-Anterior (MMA) subregions mouse PPC....