A5040155709- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Motor Control and Adaptation
- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- Visual perception and processing mechanisms
- Risk and Safety Analysis
- Fault Detection and Control Systems
- Face Recognition and Perception
- Neural and Behavioral Psychology Studies
- Ferroelectric and Negative Capacitance Devices
- Neuroscience and Neuropharmacology Research
- Neurobiology of Language and Bilingualism
- Visual Attention and Saliency Detection
- Cell Image Analysis Techniques
- Neuroscience and Music Perception
- Image and Signal Denoising Methods
- Blind Source Separation Techniques
- Tactile and Sensory Interactions
- Language Development and Disorders
- Action Observation and Synchronization
Massachusetts General Hospital
2022-2025
Harvard University
2022-2025
KU Leuven
2018-2022
Allen Institute for Brain Science
2020-2021
VIB-KU Leuven Center for Brain & Disease Research
2018-2021
California Institute of Technology
2020-2021
Abstract Humans are capable of generating extraordinarily diverse articulatory movement combinations to produce meaningful speech. This ability orchestrate specific phonetic sequences, and their syllabification inflection over subsecond timescales allows us thousands word sounds is a core component language 1,2 . The fundamental cellular units constructs by which we plan words during speech, however, remain largely unknown. Here, using acute ultrahigh-density Neuropixels recordings sampling...
From sequences of speech sounds
High-density electrophysiology probes have opened new possibilities for systems neuroscience in human and non-human animals, but probe motion poses a challenge downstream analyses, particularly recordings. We improve on the state of art tracking this with four major contributions. First, we extend previous decentralized methods to use multiband information, leveraging local field potential (LFP) addition spikes. Second, show that LFP-based approach enables registration at sub-second temporal...
ABSTRACT High-density electrophysiology probes have opened new possibilities for systems neuroscience in human and non-human animals, but probe motion (or drift) while recording poses a challenge downstream analyses, particularly recordings. Here, we improve on the state of art tracking this drift with an algorithm termed DREDge ( D ecentralized R egistration E lectrophysiology ata) four major contributions. First, extend previous decentralized methods to exploit multiband information,...
High-density microelectrode arrays (MEAs) have opened new possibilities for systems neuroscience in human and non-human animals, but brain tissue motion relative to the array poses a challenge downstream analyses, particularly recordings. We introduce DREDge (Decentralized Registration of Electrophysiology Data), robust algorithm which is well suited registration noisy, nonstationary extracellular electrophysiology In addition estimating from spikes action potential (AP) frequency band,...
Abstract Efficient object grasping requires the continuous control of arm and hand movements based on visual information. Previous studies have identified a network parietal frontal areas that is crucial for prehension movements. Electrical microstimulation 3D shape-selective clusters in AIP during functional magnetic resonance imaging activates F5a 45B, suggesting these may represent important downstream processing grasping, but role area 45B unknown. To assess their causal network, we...
Abstract Efficient object grasping requires the continuous control of arm and hand movements based on visual information. Previous studies have identified a network parietal frontal areas that is crucial for prehension movements. Electrical microstimulation 3D shape-selective clusters in AIP during fMRI activates F5a 45B, suggesting these may represent important downstream processing grasping, but role area 45B unknown. To assess their causal network, we reversibly inactivated F5p...
The cortical network controlling the arm and hand when grasping objects consists of several areas in parietal frontal cortex. Recently, more anterior prefrontal have also been implicated object grasping, but their exact role is currently unclear. To investigate neuronal encoding during these regions relation with other network, we performed large-scale recordings (more than 2000 responsive sites) cortex monkeys a saccade-reach-grasp task. When an appeared peripheral vision, first burst...
Abstract To perform real-world tasks like grasping, the primate brain has to process visual object information so that grip aperture can be adjusted before contact with is made. Previous studies have demonstrated posterior subsector of Anterior Intraparietal area (pAIP) connected frontal 45B, and anterior AIP (aAIP) F5a (Premereur et al., 2015). However, role 45B in visually-guided grasping poorly understood. Here, we investigated F5p grasping. If a neuronal response an during passive...
Abstract To perform tasks like grasping, the brain has to process visual object information so that grip aperture can be adjusted before touching object. Previous studies have demonstrated posterior subsector of Anterior Intraparietal area (pAIP) is connected 45B, and its anterior counterpart (aAIP) F5a. However, role 45B F5a in visually-guided grasping poorly understood. Here, we investigated F5p processing during two monkeys. If presentation an activates a motor command related preshaping...
Previous studies have shown that neurons in parieto-frontal areas of the macaque brain can be highly selective for real-world objects, disparity-defined curved surfaces, and images objects (with without disparity) a similar manner as described ventral visual stream. In addition, are believed to convert object information into appropriate motor outputs, such pre-shaping hand during grasping. To better characterize selectivity cortical network involved visuomotor transformations, we provide...
Previous studies have shown that neurons in parieto-frontal areas of the macaque brain can be highly selective for real-world objects, disparitydefined curved surfaces, and images objects (with without disparity) a similar manner as described ventral visual stream.In addition, are believed to convert object information into appropriate motor outputs, such pre-shaping hand during grasping.To better characterize selectivity cortical network involved visuomotor transformations, we provide...
Abstract We make eye movements to objects before grasping these objects, and the gaze direction generally indicates where object will be grasped. Hence, brain has coordinate eye-, arm- hand movements. performed large-scale recordings (more than 2000 responsive sites) in frontal cortex of monkeys during a saccade-reach-grasp task. When an appeared peripheral vision, first burst activity emerged prearcuate areas (the FEF area 45B), followed by dorsal ventral premotor cortex, buildup primary...
To perform tasks like grasping, the brain has to process visual object information so that grip aperture can be adjusted before touching object. Previous studies have demonstrated posterior subsector of Anterior Intraparietal area is connected 45B, and its anterior counterpart F5a. However, role 45B F5a in visually-guided grasping poorly understood. Here, we investigated F5p processing during two monkeys. We tested whether presentation an near peripersonal space activated neurons more than...