A5000955182- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Neutropenia and Cancer Infections
- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Antifungal resistance and susceptibility
- Chronic Myeloid Leukemia Treatments
- Fungal Infections and Studies
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Oral health in cancer treatment
- Hematological disorders and diagnostics
- Eosinophilic Disorders and Syndromes
- CNS Lymphoma Diagnosis and Treatment
- Blood disorders and treatments
- Nutrition and Health in Aging
- interferon and immune responses
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chemotherapy-related skin toxicity
- Polyomavirus and related diseases
Kawasaki Medical School
2024-2025
Kagawa University
2015-2024
Kagawa University Hospital
2008-2024
Dana-Farber Cancer Institute
2009-2023
Brigham and Women's Hospital
2010-2023
Harvard University
2010-2023
Kyoto University
2019-2021
Shizuoka Cancer Center
2005-2017
Ontario Institute for Cancer Research
2011
Princess Margaret Cancer Centre
2011
Although advanced-stage melanoma patients have a median survival of less than year, adoptive T cell therapy can induce durable clinical responses in some patients. Successful to treat cancer requires engraftment antitumor lymphocytes that not only retain specificity and function vivo but also display an intrinsic capacity survive. To date, adoptively transferred CD8(+) (CTLs) had limited life spans unless the host has been manipulated. generate CTLs persist vivo, we developed human...
Methotrexate (MTX) is used as an anchor drug for rheumatoid arthritis (RA). Lymphoproliferative disease (LPD) occasionally develops in patients treated with MTX, and known MTX-associated LPD (MTX-LPD). Although MTX-LPD occurs mainly RA patients, it has not been established if MTX administration independent risk factor patients. We examined the clinical characteristics of Japanese attempted to determine factors development.We performed a nested case-control study on enrolled 5,753 from...
Many preclinical experiments have attested to the critical role of CD4+ T cell help in CD8+ cytotoxic lymphocyte (CTL)-mediated immunity. Recent clinical trials demonstrated that reinfusion cells can induce responses infectious diseases and cancer. However, few standardized versatile systems exist expand antigen-specific Th for use. K562 is a human erythroleukemic line, which lacks expression HLA class I II, invariant chain HLA-DM but expresses adhesion molecules such as intercellular...
Using in vivo mouse models, the mechanisms of CD4+ T cell help have been intensively investigated. However, a mechanistic analysis human is largely lacking. Our goal was to elucidate CD8+ proliferation using novel vitro model.We developed genetically engineered cell-based artificial APC, aAPC/mOKT3, which expresses membranous form anti-CD3 monoclonal antibody OKT3 as well other immune accessory molecules. Without requiring addition allogeneic feeder cells, aAPC/mOKT3 enabled expansion both...
Small-cell lung cancer (SCLC) is intractable due to its high propensity for relapse. Novel agents are thus needed SCLC treatment. Lemongrass essential oil (LG-EO) and major constituent, citral, have been reported inhibit the proliferation survival of several types cells. However, precise mechanisms through which LG-EO citral exert their effects on cells not fully elucidated. express Src levels Src-tyrosine kinase (Src-TK) activity. In most cell lines, constitutive phosphorylation...
Oncolytic herpes simplex virus type 1 (HSV-1) has been investigated to expand its application various malignancies. Because hematopoietic cells are resistant HSV-1, hematological malignancies rare. Here, we show that the third generation oncolytic T-01, infected and killed 18 of 26 human cell lines 8 15 primary derived from lineages T-01 replicated at low levels in lines. Viral entry effect were positively correlated with expression level nectin-1 a lesser extent 3-O-sulfated heparan...
Human multiple myeloma (MM) is an incurable hematological malignancy for which novel therapeutic agents are needed. Calmodulin (CaM) antagonists have been reported to induce apoptosis and inhibit tumor cell invasion metastasis in various models. However, the antitumor effects of CaM on MM poorly understood. In this study, we investigated naphthalenesulfonamide derivative selective W-7 W-13 lines both vitro vivo.The proliferative ability was analyzed by WST-8 assay. Cell cycle evaluated flow...
Abstract Background Acute myeloid leukemia (AML) is a progressive hematological malignancy that can be fatal when left untreated. However, spontaneous remission rarely observed in the presence of infectious diseases. Case presentation We treated an 80-year-old woman with AML who spontaneously underwent after infections. Spontaneous was each three independent clinical infections caused by different pathogens—nontuberculous Mycobacterium infection, pulmonary aspergillosis, and Escherichia coli...
BACKGROUND Fermenting bacilli producing lactic acid, including Bifidobacterium spp., are supposed to have low pathogenicity and no virulence for humans. Probiotics consisting of those fermenting can prevent treat symptomatic gastrointestinal conditions, such as diarrhea. We use probiotics even in cancer patients, who immunocompromised, because a preferable effect the intestinal commensal microbiome has been shown recent report. Some case reports warn rare risk bloodstream infection caused by...
BACKGROUND: TRALI is one of the most serious, life‐threatening complications after blood transfusion. Antibodies against neutrophils or HLA molecules from donor are thought to be primary causative agents. Rarely, antibodies in recipient may react with transfused and initiate same events, which raises possibility that also occur an allogeneic PBPC transplantation setting. CASE REPORT: A 30‐year‐old Japanese man acute lymphoblastic leukemia developed immediately infusion marrow cells unrelated...
There have been no detailed analyses of the induction donor cell-type chimerism, onset and incidence acute chronic graft-versus-host disease (GVHD), immune recovery kinetics after reduced-intensity stem cell transplantation (RIST).To address these, with particular emphasis on impact use antithymocyte globulin (ATG) in RIST, we compared 39 consecutively registered patients who underwent RIST from an HLA-matched related 33 conventional marrow-ablative transplantation.The incidences grades II...
In previous cancer vaccine clinical trials targeting survivin, induction of specific CD8(+) T-cell responses did not consistently lead to responses. Considering the critical role CD4(+) help in generating antitumor immunity, integration anti-survivin may enhance efficacy immunotherapy. Human leukocyte antigen (HLA)-DP4 is emerging as an attractive MHC target allele T cell-mediated immunotherapy, because it one most frequent HLA alleles many ethnic groups. this article, we aimed elucidate...
Allogeneic stem cell transplantation (SCT) from an HLA-matched sibling donor (MSD) is a postremission treatment that offers potential cure for adults with cytogenetically normal (CN) acute myelogenous leukemia (AML) in first complete remission (CR1). The best alternative the absence of MSD remains unclear, however. aim this study was to retrospectively compare outcomes autologous peripheral blood (auto-PBSCT; n = 177) and allogeneic bone marrow (BMT) unrelated (MUD; 173) adult patients...
This prospective study evaluates the safety and efficacy of pravastatin for treatment chronic graft-versus-host disease (GVHD). We included 18 patients with refractory GVHD. Oral was started at 10 mg/day, dose increased up to 40 mg/day in 4 weeks. maximum administered over 8 There were no severe adverse events caused by pravastatin. A clinical response observed skin score two patients, mouth five eye liver three platelet count one patient, weight loss patients. The overall rate 28%....
Abstract Intravascular large B‐cell lymphoma (IVLBCL) is a rare characterized by the presence of tumour cells within blood vessels. It has been considered that IVLBCL highly malignant disease with poor prognosis. However, it shown therapeutic effect resembling conventional lymphomas may be obtained application systemic chemotherapy at early stage this disease. Although involvement in lung often detected autopsy, diagnosis quite difficult. In report, we present case pulmonary where...