Ling Shan

ORCID: 0000-0001-5356-3956
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About
Contact & Profiles
Research Areas
  • Autism Spectrum Disorder Research
  • Child Nutrition and Feeding Issues
  • Child Development and Digital Technology
  • Attention Deficit Hyperactivity Disorder
  • Vitamin D Research Studies
  • Cerebral Palsy and Movement Disorders
  • Additive Manufacturing Materials and Processes
  • High Entropy Alloys Studies
  • Crystallization and Solubility Studies
  • Aluminum Alloys Composites Properties
  • COVID-19 and Mental Health
  • Genetics and Neurodevelopmental Disorders
  • X-ray Diffraction in Crystallography
  • Infant Development and Preterm Care
  • Additive Manufacturing and 3D Printing Technologies
  • Acupuncture Treatment Research Studies
  • Family and Disability Support Research
  • Botulinum Toxin and Related Neurological Disorders
  • Impact of Technology on Adolescents
  • MXene and MAX Phase Materials
  • Educational Methods and Impacts
  • Boron and Carbon Nanomaterials Research
  • Connective tissue disorders research
  • Electromagnetic wave absorption materials
  • Epigenetics and DNA Methylation

Jilin University
2015-2025

First Hospital of Jilin University
2015-2025

Guangzhou Metro Design & Research Institute
2024

Zhejiang Medicine (China)
2024

Guangzhou Metro Group (China)
2024

Weatherford College
2020

Associated Research (United States)
2020

Autism spectrum disorder (ASD) is a common neurodevelopmental caused by complex interaction between genetic and environmental risk factors. Among the factors, vitamin D3 (cholecaliferol) seems to play significant role in etiology of ASD because this important for brain development. Lower concentrations may lead increased size, altered shape, enlarged ventricles, which have been observed patients with ASD. Vitamin converted into 25-hydroxyvitamin liver. Higher serum steroid reduce autism....

10.1542/peds.2014-2121 article EN PEDIATRICS 2014-12-16

High prevalence of vitamin D deficiency was previously reported in children with Autism Spectrum Disorder (ASD), but little is known about the efficacy D3 treatment ASD, although data from pilot studies seem promising. We hypothesized that serum levels are reduced ASD and correlate severity disease. Also, we may be beneficial for a considerable portion ASD.In total, 215 285 healthy control were recruited our study. Thirty seven received treatment. The Behaviour Checklist (ABC) Childhood...

10.1080/1028415x.2015.1123847 article EN Nutritional Neuroscience 2016-01-18

Objective: The purpose of this study was to investigate the therapeutic effects combined bumetanide and applied behavior analysis (ABA) treatment in children with autism. Methods: Sixty diagnosed autism according International Classification Diseases, Tenth Revision (ICD-10) criteria (mean age 4.5 years) were randomly divided into two groups: A single group (n=28) a (n=32). received ABA training oral (0.5 mg twice day). only. Autism symptoms evaluated Behavior Checklist (ABC) Childhood...

10.1089/cap.2015.0045 article EN Journal of Child and Adolescent Psychopharmacology 2015-08-10

Background Previous studies have mostly explored the comorbidities of Global developmental delay (GDD) in children with Autism Spectrum Disorders (ASD) from perspective ASD. The study focus on GDD to investigate prevalence and profiles ASD explore correlation between level symptoms autism. Methods Clinical data 521 aged 24 60 months were retrospectively analyzed. Analyses performed first for whole sample then subdivided into two subgroups (GDD + − , ) according whether had Symptoms autism...

10.3389/fpsyt.2021.794238 article EN cc-by Frontiers in Psychiatry 2022-01-18

In order to meet the demand for structural/functional integrated materials in field of electromagnetic shielding, a graphene nanosheets (GNSs) reinforced magnesium matrix composite was fabricated using an electrophoretic deposition and subsequent accumulative roll bonding process (ARB). The microstructure, mechanical properties, interference (EMI) shielding effectiveness (SE) GNSs/Mg composites were characterized systematically. results showed that synergistic strengthening properties EMI...

10.3390/coatings15030250 article EN Coatings 2025-02-20

Abstract This study aims to explore the psychosocial and behavioral problems of children adolescents in early stage reopening schools. In this national cross-sectional study, a total 11072 students from China were naturally divided into two groups based on their schooling status: reopened schools (RS) home (HS) group. The functioning measured by Achenbach Child Behaviour Checklist (CBCL) compared these groups. Multivariable logistic regression analyses conducted independent predictors...

10.1038/s41398-021-01462-z article EN cc-by Translational Psychiatry 2021-06-03

Objective: To investigate the current status of screen time in children with ASD, its correlation autistic symptoms and developmental quotient (DQ), factors affecting time. Method: One hundred ninety-three Chinese ASD were recruited. We collected demographic data using a questionnaire. The core (DQ) measured by Autism Behavior Checklist (ABC), Childhood Rating Scale (CARS), Diagnostic Observation Schedule-Second Edition (ADOS-2), Griffiths Development Scales-Chinese Language (GDS-C),...

10.3389/fpsyt.2021.675902 article EN cc-by Frontiers in Psychiatry 2021-08-06

Abstract Background This study evaluated vitamin A (VA), copper (Cu), and zinc (Zn) levels in the population with autism spectrum disorder (ASD) Jilin Province, China. Furthermore, we examined their links to core symptoms neurodevelopment, as well gastrointestinal (GI) comorbidities sleep disorders. Methods included 181 children 205 typically developing (TD) children. The participants had not taken vitamin/mineral supplements prior three months. High-performance liquid chromatography was...

10.1186/s12887-023-03987-2 article EN cc-by BMC Pediatrics 2023-04-13

Autism spectrum disorder (ASD) is a common neurodevelopmental caused by complicated interactions between genetic and environmental factors. Clinical trials, including case reports, case–control studies, double-blinded randomized clinical study, have suggested that high-dose vitamin D3 regimens may ameliorate the core symptoms of ASD. Vitamin supplementation was effective in about three-quarters children with To further investigate relationship D ASD D-responsive autistic children, changes...

10.1080/1028415x.2018.1458421 article EN Nutritional Neuroscience 2018-04-08

Objective: This study aimed to investigate the possible association among vitamin D, screen time and other factors that might affect concentration of D in children with autism spectrum disorder (ASD). Methods: In total, 306 ASD were recruited, data, including their age, sex, height, weight, time, outdoor activity, symptoms [including Autism Behavior Checklist (ABC), Childhood Rating Scale (CARS) Diagnostic Observation Schedule-Second Edition (ADOS-2)] concentrations, collected. A multiple...

10.3389/fped.2021.806981 article EN cc-by Frontiers in Pediatrics 2022-01-13

The aim of this study is to evaluate serum 25-hydroxyvitamin D[25(OH)D] levels in children with tic disorders and explore the relationship between 25(OH)D level severity. Children (n = 179, 31 females, 148 males, mean age at diagnosis: 8.0 ± 2.7 years old, ranged from 3 14.5 old) who were diagnosed a disorder enrolled as case group, 189 healthy recruited control group. Serum each child was measured by high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS). Yale Global...

10.1016/j.psychres.2018.05.066 article EN cc-by-nc-nd Psychiatry Research 2018-06-01

Objective To analyze the risk factors for developmental quotients (DQs) of children with autism spectrum disorder (ASD) and to better understand effects screen time on neurodevelopment in ASD. Methods We retrospectively analyzed data 382 ASD, including demographic profiles; socioeconomic status; score Chinese parent–child interaction scale (CPCIS); questionnaire; ASD symptom rating scales, Autism Behavior Checklist (ABC), Childhood Rating Scale (CARS), Diagnostic Observation Schedule Second...

10.3389/fpsyg.2023.1126622 article EN cc-by Frontiers in Psychology 2023-03-13

In the present study, densification behavior, microstructural evolution, mechanical properties, and friction behavior of a TiB2/Al8SiCu composite Al8SiCu alloy manufactured by laser powder-bed fusion (PBF-LB) were systematically investigated. The results confirm that addition in situ TiB2 particles into alloys reduce volumetric energy density required for high-density composite. promoted transformation columnar to equiaxed crystals formation high-angle grain boundaries. grains on vertical...

10.3390/met14091015 article EN cc-by Metals 2024-09-05

The recent discovery of the novel boron-framework in boron-rich metal borides with complex structures and intriguing features under high pressure has stimulated search into unique boron-network monoborides or boron-deficient at pressure. Herein, based on particle swarm optimization algorithm combined first-principles calculations, we thoroughly explored structural evolution properties TiB up to 200 GPa. This material undergoes a pressure-induced phase transition Pnma → Cmcm Pmmm . Besides...

10.1088/1674-1056/ac9222 article EN Chinese Physics B 2022-09-15

Abstract Rationale: Autism spectrum disorder (ASD) is a common neurodevelopmental caused by complex interactions between genetic and environmental factors. Recent studies suggest that Vitamin D 3 or bumetanide therapy may improve the core symptoms of ASD in some individuals. However, there are no guidelines provide clinicians with evidence-based treatment regimens for use these therapies ASD. Patient concerns: A 30-month-old female was referred to our department because she did not respond...

10.1097/md.0000000000018661 article EN cc-by-nc Medicine 2020-01-01

Abstract ZNF148 gene is a Krüppel‐type transcription factor that has transcriptional regulatory function. Heterozygous variant in causes an intellectual disability syndrome characterized by global developmental delay, absence, or hypoplasia of corpus callosum, wide intracerebral ventricles, and dysmorphic facial features, while its associations with ASD ADHD have not been reported. We report new patient disability, autism spectrum disorder (ASD) attention‐deficit hyperactivity (ADHD). The...

10.1111/cge.14272 article EN Clinical Genetics 2022-11-29

Background: The significant lifestyle changes that occurred during the lockdown period associated with COVID-19 pandemic may have had many potential adverse effects on children, in particular, sedentary screen exposure among including those developmental disorders. We conducted a cross-sectional study to investigate and compare time outdoor activity of children typically development (TD) disorders before emergence COVID-19, identified risk factors related pandemic.

10.21037/tp-23-162 article EN Translational Pediatrics 2023-05-01
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