Rajan Sundaresan Vediappan

ORCID: 0000-0001-5370-8262
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About
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Research Areas
  • Sinusitis and nasal conditions
  • Intestinal and Peritoneal Adhesions
  • Head and Neck Surgical Oncology
  • Electrospun Nanofibers in Biomedical Applications
  • Infectious Diseases and Tuberculosis
  • Hemostasis and retained surgical items
  • Hernia repair and management
  • Surgical Sutures and Adhesives
  • Osteomyelitis and Bone Disorders Research
  • Spinal Fractures and Fixation Techniques
  • Otolaryngology and Infectious Diseases
  • Spine and Intervertebral Disc Pathology
  • Voice and Speech Disorders
  • Ear and Head Tumors
  • Nasal Surgery and Airway Studies
  • Head and Neck Cancer Studies
  • Mycobacterium research and diagnosis
  • Oral microbiology and periodontitis research
  • Orthopedic Infections and Treatments
  • Reconstructive Surgery and Microvascular Techniques
  • Meningioma and schwannoma management
  • Bacterial biofilms and quorum sensing
  • Phenothiazines and Benzothiazines Synthesis and Activities
  • Allergic Rhinitis and Sensitization
  • Infectious Diseases and Mycology

Christian Medical College & Hospital
2020-2025

The University of Adelaide
2019-2023

Basil Hetzel Institute
2023

Queen Elizabeth Hospital
2020

Abstract This article aims to assess the presence of skeletal and soft tissue infections before or after treatment response in Ga-68 citrate positron emission tomography/computed tomography (PET/CT) scan positive patients. A prospective study was conducted for 43 The eligibility criteria included those patients clinically suspected who underwent a PET/CT. Exclusion were pregnancy lactation. Patients with suspicion infection failure PET/CT between January 2020 November 2021. Among these,...

10.1055/s-0045-1807256 article EN cc-by World Journal of Nuclear Medicine 2025-04-01

Background Chronic rhinosinusitis patients (CRS) suffer from chronic inflammation of the sinus mucosa associated with relapsing infections. Mucosal biofilms, Staphylococcus aureus , have been implicated as a cause. We compared effect exoproteins secreted clinical isolates S CRS in planktonic and biofilm form on nasal epithelial barrier. Methods Clinical 39 were grown forms their concentrated. These applied to primary human cells at air‐liquid interface. Transepithelial electrical resistance,...

10.1002/alr.22566 article EN International Forum of Allergy & Rhinology 2020-06-07

Background: Adhesion formation after abdominal surgery is considered almost inevitable and a major cause of morbidity. Novel treatments have been proposed, however there lack suitable small animal models for pre-clinical evaluation, mainly due to inconsistency in adhesion positive control animals. Here, we propose new rat model adhesions using Kaolin as the adhesion-inducing agent at an optimized dosage testing newer agents respect their anti-adhesive property. Materials Methods: Twenty-five...

10.3389/fsurg.2020.00012 article EN cc-by Frontiers in Surgery 2020-04-08

Introduction: Allergic fungal rhinosinusitis (AFRS), a subset of sinusitis secondary to hypersensitivity, is clinically similar chronic with nasal polyp but histologically different rich eosinophils and Charcot Leyden crystals. Since the primary pathology in AFRS immune mediated, recurrence rates are high. In this study, we describe application radical extended sinus surgery (RESS) as surgical technique usage postoperative high-volume steroidal irrigation short-term oral steroid therapy –...

10.4103/cmi.cmi_3_24 article EN cc-by-nc-sa Current Medical Issues 2024-06-26

Introduction Adhesions are often considered to be an inevitable consequence of abdominal and pelvic surgery, jeopardizing the medium long-term success these procedures. Numerous strategies have been tested reduce adhesion formation, however, date, no surgical or medical therapeutic approaches successful in its prevention. This study demonstrates safety efficacy Chitogel with Deferiprone and/or antibacterial Gallium Protoporphyrin different concentrations preventing formation after surgery....

10.1371/journal.pone.0244503 article EN cc-by PLoS ONE 2021-01-14

This study aimed to determine the safety and efficacy of Chitogel, with without Deferiprone (Def) Gallium Protoporphyrin (GaPP), as a promoter wound healing improve surgical outcomes after endoscopic sinus susgery.A double-blinded, randomised control human clinical trial was conducted in patients undergoing ESS treatment for chronic rhinosinusitis. Participants underwent functional or FESS drill out required were receive test product Chitogel combination Def Def-GaPP versus no packing...

10.1111/coa.13996 article EN cc-by Clinical Otolaryngology 2022-11-01

Abstract Background As the scope of endoscopic techniques continues to evolve in treatment advanced sinonasal malignancies, primary challenge is reconstruction resulting anterior skull base dural defect. Objective This study aimed assess efficacy vascularized pericranial flap addressing defects particularly when alternative reconstructive methods, such as nasoseptal flaps, are not viable. Methods We conducted a retrospective review nine patients who underwent resection malignancy followed by...

10.1055/s-0044-1792079 article EN Journal of Neurological Surgery Part B Skull Base 2024-10-28

Apparent diffusion coefficient (ADC) value helps in differentiating infections from neoplasms on magnetic resonance imaging (MRI). We investigate the diffusion-weighted images skull base osteomyelitis (SBO) to evaluate if ADC values can differentiate fungal and bacterial SBO analyse microbiology of all patients.

10.1111/coa.14256 article EN Clinical Otolaryngology 2024-11-12

Intraoperative hemorrhage is a major cause of poor post-operative outcome. Beta-chitin patch has previously been found to be an effective haemostat, but whether modifying the can improve its efficacy and safety, remains unknown. In this study, beta-chitin patches were modified using polyethylene oxide, Pluronic-F127 (Chi/F127), calcium (Chi/20%Ca), increased thickness (Chi/Thick) or polyphosphate (Chi/PP).Using rat (Wistar Albino; 8-10 weeks old) vascular neurosurgical models, project...

10.3389/fsurg.2022.830364 article EN cc-by Frontiers in Surgery 2022-04-08
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