A5044039193- Aquaculture Nutrition and Growth
- Physiological and biochemical adaptations
- Acute Myocardial Infarction Research
- Aquaculture disease management and microbiota
- Renin-Angiotensin System Studies
- Nerve injury and regeneration
- Receptor Mechanisms and Signaling
- Fish Ecology and Management Studies
- Retinal Diseases and Treatments
- Adenosine and Purinergic Signaling
- Retinal Imaging and Analysis
- Parkinson's Disease Mechanisms and Treatments
- Reproductive biology and impacts on aquatic species
- Coronary Interventions and Diagnostics
- Sex and Gender in Healthcare
- Heme Oxygenase-1 and Carbon Monoxide
- Nuclear Receptors and Signaling
- Astrophysics and Cosmic Phenomena
- Mechanical Circulatory Support Devices
- Neuroinflammation and Neurodegeneration Mechanisms
- Dark Matter and Cosmic Phenomena
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurogenesis and neuroplasticity mechanisms
- Solar and Space Plasma Dynamics
- Cardiac Structural Anomalies and Repair
Universidade de Santiago de Compostela
2001-2022
Complejo Hospitalario Universitario de Santiago
2020-2022
Centro de Supercomputación de Galicia
2002-2021
October 6 University
2001
Abstract Cell death induced by 6‐hydroxydopamine (6‐OHDA) is thought to be caused reactive oxygen species (ROS) derived from 6‐OHDA autooxidation and a possible direct effect of on the mitochondrial respiratory chain. However, process has not been totally clarified. In rat primary mesencephalic cultures, we observed significant increase in dopaminergic (DA) cell loss 24 h after administration (40 μmol/L) NADPH subunit expression, microglial activation superoxide anion/superoxide‐derived ROS...
The neurotoxin MPTP reproduces most of the biochemical and pathological hallmarks Parkinson's disease. In addition to reactive oxygen species (ROS) generated as a consequence mitochondrial complex I inhibition, microglial NADPH-derived ROS play major roles in toxicity MPTP. However, exact mechanism regulating this response remains be clarified. peptide angiotensin II (AII), via type 1 receptors (AT1), is one important inflammation oxidative stress inducers, produces by activation...
OBJECTIVE—Detecting and grading of diabetic retinopathy (DR) by means digital retinal images sent via the Internet. RESEARCH DESIGN AND METHODS—Four nonstereoscopic (45° field each) 126 eye fundus from 70 patients were obtained with a nonmydriatic camera at two peripheral units. The Internet using web-based system to reference center, where they diagnosed graded one ophthalmologist. These results compared those other ophthalmologists, each unit, after direct examination patients. A modified...
Abstract It is now established that the brain possesses a local renin‐angiotensin system and angiotensin II exerts multiple actions in nervous system, including regulation of striatal dopamine release. Furthermore, activates NADPH‐dependent oxidases, which are major source superoxide, angiotensin‐converting enzyme inhibitors, commonly used treatment hypertension chronic heart failure, have shown antioxidant properties several tissues. Oxidative stress key contributor to pathogenesis...
Abstract The results of several in vitro studies have shown that cysteine prodrugs, particularly N‐acetylcysteine, are effective antioxidants increase the survival dopaminergic neurons. N‐acetylcysteine can be systemically administered to deliver brain and is potential use for providing neuroprotection treatment Parkinson's disease. However, it has also been reported an excess may induce neurotoxicity. In present study, we injected adult rats intrastriatally with 2.5 μl 6‐hydroxydopamine...
Epidermal growth-factor-responsive rat mesencephalic precursor cells incubated in differentiation media produce only a small number of dopaminergic (DA) cells. Supplementation the medium with N-acetylcysteine (NAC) induced marked increase (∼400%) tyrosine hydroxylase (TH)-positive Treatment interleukin-1α also significant (∼300%) TH-positive However, we did not find additive effects between these drugs. The results suggest that NAC is effective production DA from precursors, and this may be...
Research on cosmic rays is of big interest either for getting a better understanding about their origin and properties or because they offer very valuable information the galactic, solar Earth's environment. In order to improve our knowledge all those fields, high resolution ray tracking detector, TRAGALDABAS, being commissioned at Faculty Physics Univ. Santiago de Compostela (Spain). this article we make overview main performances detector present some preliminary results showing that...
Abstract Seasonal changes on gill ATPases activities of domesticated rainbow trout (Salmo gairdneri ), reared under natural conditions, were studied during 1988. There is a peak in the (Na+‐K+) ATPase activity between May 10th and July 13rd. The highest average appears June, just before after summer solstice (June 15th 29th). Ca2+‐, Mg2+‐ HCO 3‐ATPases show annual significant variations their (p<0.05); nevertheless, none them present seasonal pattern. It seems to be that, all implicated...
The dynamics of the levels and metabolism dopamine, norepinephrine, serotonin were studied in pituitaries male female rainbow trout at different stages gonadal development. In trout, turnover dopamine (calculated using inhibitor tyrosine hydroxylase α‐methyl‐p‐tyrosine methyl‐ester HCl), metabolism, norepinephrine decreased advanced stage exogenous vitellogenesis with respect to initial stage. Data obtained males did not show changes either serotonergic or noradrenergic during last...
Abstract Seasonal changes on intestinal ATPases activities of domesticated rainbow trout (Salmo gairdneri), reared under natural conditions, were studied during 1988. (Na+/K+)‐ATPase activity shows peak in all regions, between May and July. Ca2+, Mg2+ HCO3‐ATPases show significant variations, none present a seasonal pattern. is positively correlated to both temperature photoperiod, negative correlation exists HCO3‐ATPase regions. The data demonstrates that the enzymes which could be involved...
Abstract The search for alternative sources of dopaminergic cells, other than primary fetal tissue transplantation in Parkinson's disease has become a major focus research. Different methodological approaches have led to generation vitro cells expressing DA‐cell markers, although these are frequently unable survive long time vivo after and/or induce functional effects the host brain. In present study, we grafted cell aggregates treated with antibodies against fibroblast growth factor 4 into...
Cosmic rays originating from extraterrestrial sources are permanently arriving at Earth atmosphere, where they produce up to billions of secondary particles. The analysis the particles reaching surface may provide a very valuable information about Sun activity, changes in geomagnetic field and among others. In this article, we present first preliminary results cosmic measured with high resolution tracking detector, TRAGALDABAS, located Univ. Santiago de Compostela, Spain.
This paper describes a case of the implementation pan-European operational oceanography service coexisting with non-operative research jobs that are executed on same computational resources. The complexity designing good increases when resources will be used shared other workloads. However, once is achieved result an optimised and robust service. Computational necessary services permanently monitored in order to detect solve potential problems real-time. These can by researchers during time...
Renal dysfunction in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) indicates a poor long-term prognosis. However, the prognostic value of improvement or stabilisation renal function during follow-up has not yet been assessed. This study aimed to investigate predictive impact after one year STEMI pPCI at discharge.This prospective, single-centre cohort included 2170 consecutive who underwent pPCI. The glomerular...