A5013759313- Acute Myeloid Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Plant and Fungal Interactions Research
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- T-cell and Retrovirus Studies
- Phagocytosis and Immune Regulation
- Plant Disease Resistance and Genetics
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Plant Virus Research Studies
National Taiwan University Hospital
2022-2024
National Taiwan University
2005-2017
Additional sex combs-like 1 (ASXL1) is frequently mutated in myeloid malignancies. Recent studies showed that hematopoietic-specific deletion of Asxl1 or overexpression mutant ASXL1 resulted myelodysplasia-like disease mice. However, actual effects a "physiological" dose remain unexplored. We established knock-in mouse model bearing the most frequent mutation and studied its pathophysiological on hematopoietic system. Heterozygotes (Asxl1 tm/+ ) marrow cells had higher vitro proliferation...
Homeodomain-only protein homeobox (HOPX) is the smallest homeodomain protein. It was regarded as a stem cell marker in several non-hematopoietic systems. While prototypic genes such HOX family have been well characterized acute myeloid leukemia (AML), clinical and biological implications of HOPX disease remain unknown. Thus we analyzed global gene expression patterns 347 newly diagnosed de novo AML patients our institute. We found that higher closely associated with older age, platelet...
Plant homeodomain finger gene 6 (PHF6) encodes a 365-amino-acid protein containing 2 plant homology domain fingers. Germline mutations of human PHF6 cause Börjeson-Forssman-Lehmann syndrome, congenital neurodevelopmental disorder. Loss-of-function are detected in patients with acute leukemia, mainly T-cell lineage and small proportion myeloid lineage. The functions physiological hematopoiesis leukemogenesis remain incompletely defined. To address this question, we generated conditional Phf6...
Somatic Nucleophosmin (NPM1) mutation frequently occurs in acute myeloid leukemia (AML), but its role leukemogenesis remains unclear. This study reports the first “conventional” knock-in mouse model of Npm1 mutation, which was achieved by inserting TCTG after nucleotide c.857 (c.854_857dupTCTG) to mimic human without any “humanized” sequence. The resultant mutant peptide differed slightly different from that humans exhibited cytoplasmic pulling force. Homozygous (Npm1c+/c+) mice showed...