A5039613954- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Congenital Heart Disease Studies
- Marine Invertebrate Physiology and Ecology
- Single-cell and spatial transcriptomics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Cardiac Arrhythmias and Treatments
- Nutrition and Health in Aging
- Phagocytosis and Immune Regulation
- Immunodeficiency and Autoimmune Disorders
- Kruppel-like factors research
- RNA modifications and cancer
- Coronary Artery Anomalies
- Bariatric Surgery and Outcomes
- Immune Cell Function and Interaction
- Connexins and lens biology
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
National Taiwan University Hospital
2017-2024
National Taiwan University
2017-2022
Additional sex combs-like 1 (ASXL1) is frequently mutated in myeloid malignancies. Recent studies showed that hematopoietic-specific deletion of Asxl1 or overexpression mutant ASXL1 resulted myelodysplasia-like disease mice. However, actual effects a "physiological" dose remain unexplored. We established knock-in mouse model bearing the most frequent mutation and studied its pathophysiological on hematopoietic system. Heterozygotes (Asxl1 tm/+ ) marrow cells had higher vitro proliferation...
Homeodomain-only protein homeobox (HOPX) is the smallest homeodomain protein. It was regarded as a stem cell marker in several non-hematopoietic systems. While prototypic genes such HOX family have been well characterized acute myeloid leukemia (AML), clinical and biological implications of HOPX disease remain unknown. Thus we analyzed global gene expression patterns 347 newly diagnosed de novo AML patients our institute. We found that higher closely associated with older age, platelet...
Plant homeodomain finger gene 6 (PHF6) encodes a 365-amino-acid protein containing 2 plant homology domain fingers. Germline mutations of human PHF6 cause Börjeson-Forssman-Lehmann syndrome, congenital neurodevelopmental disorder. Loss-of-function are detected in patients with acute leukemia, mainly T-cell lineage and small proportion myeloid lineage. The functions physiological hematopoiesis leukemogenesis remain incompletely defined. To address this question, we generated conditional Phf6...
Laparoscopic sleeve gastrectomy (LSG) is an effective treatment for patients with morbid obesity, but the optimal gastric volume (GV) resection remains unclear. Accordingly, we aimed to determine percentage of excised stomach that could engender significant weight loss and improve fatty liver. This prospective study included 63 patients. Computed tomography (CT) scans were performed before 1 year after LSG evaluate lumen (GL) GV. Specifically, was distended effervescent powder, following...
mutation is an unfavorable prognostic factor in patients with primary myelofibrosis (PMF) but its effect on (MF) remains largely unclear.
The homeodomain protein homeobox (HOPX), a multifaceted regulator of cellular functions and developmental processes, is predominantly expressed in stem cells across diverse tissues; it has also emerged as tumour suppressor various solid cancers. However, its role haematological malignancies still remains undefined. This study aimed to elucidate significance T-cell acute lymphoblastic leukaemia (T-ALL). We firstly uncovered novel link between reduced HOPX expression, promoter hypermethylation...
Contrast pooling (CP) reconstruction is widely used in computed tomography (CT) studies of congenital heart diseases. However, endovascular devices are usually obscured CP. To improve visualization the vascular lumen, we developed jellyfish angiography (JFA), a semitransparent blood pool inversion technique. Ten CT patent ductus arteriosus (PDA) or coarctation aorta (CoA) were selected retrospectively for using both CP and JFA. Four conducted before intervention, six after intervention....