A5087598092- Housing Market and Economics
- Housing, Finance, and Neoliberalism
- Gamma-ray bursts and supernovae
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Astronomy and Astrophysical Research
- Bioinformatics and Genomic Networks
- Neuropeptides and Animal Physiology
- Cancer Genomics and Diagnostics
- Banking stability, regulation, efficiency
- Astrophysics and Cosmic Phenomena
- Microbial Metabolic Engineering and Bioproduction
- Gene Regulatory Network Analysis
- Gene expression and cancer classification
- Receptor Mechanisms and Signaling
- RNA and protein synthesis mechanisms
- Pain Mechanisms and Treatments
- Urban, Neighborhood, and Segregation Studies
- CAR-T cell therapy research
- Stellar, planetary, and galactic studies
- Genomics and Phylogenetic Studies
- Legal Systems and Judicial Processes
- Taxation and Legal Issues
- Global Financial Regulation and Crises
- Bacterial Genetics and Biotechnology
Institut de génétique et de biologie moléculaire et cellulaire
2014-2025
Bristol-Myers Squibb (United States)
2020-2025
Université de Strasbourg
2011-2024
Inserm
2010-2024
Centre National de la Recherche Scientifique
2010-2024
Predictive Science (United States)
2020-2024
Brooklyn Law School
2010-2023
Institute for Systems Biology
2009-2023
University of Washington
1996-2019
Bristol-Myers Squibb (Switzerland)
2019
We present spectral and photometric observations of 10 Type Ia supernovae (SNe Ia) in the redshift range 0.16 ≤ z 0.62. The luminosity distances these objects are determined by methods that employ relations between SN light curve shape. Combined with previous data from our High-z Supernova Search Team recent results Riess et al., this expanded set 16 high-redshift a 34 nearby used to place constraints on following cosmological parameters: Hubble constant (H0), mass density (ΩM), (i.e.,...
The High-Z Supernova Search is an international collaboration to discover and monitor Type Ia supernovae (SNe Ia) at z > 0.2 with the aim of measuring cosmic deceleration global curvature. Our has pursued a basic understanding in nearby universe, discovering observing large sample objects developing methods measure accurate distances SNe Ia. This paper describes extension this program ≥ 0.2, outlining our search techniques follow-up program. We have devised high-throughput filters that...
We use Type Ia supernovae studied by the High-z Supernova Search Team to constrain properties of an energy component that may have contributed accelerating cosmic expansion. find for a flat geometry equation-of-state parameter unknown component, αx = Px/ρx, must be less than -0.55 (95% confidence) any value Ωm, and it is further limited < -0.60 if Ωm assumed greater 0.1. These values are inconsistent with being topological defects such as domain walls, strings, or textures. The supernova...
We have coordinated Hubble Space Telescope (HST) photometry with ground-based discovery for three supernovae: Type Ia supernovae near z ≈ 0.5 (SN 1997ce, SN 1997cj) and a third event at = 0.97 1997ck). The superb spatial resolution of HST separates each supernova from its host galaxy leads to good precision in the light curves. use these curves relations between luminosity, light-curve shape, color calibrated low-z samples derive relative luminosity distances that are accurate 10% 20% 1....
We present a method (the Inferelator) for deriving genome-wide transcriptional regulatory interactions, and apply the to predict large portion of network archaeon Halobacterium NRC-1. The Inferelator uses regression variable selection identify influences on genes based integration genome annotation expression data. learned successfully predicted Halobacterium's global under novel perturbations with predictive power similar that seen over training Several specific predictions were...
Cohesin is required to prevent premature dissociation of sister chromatids after DNA replication. Although its role in chromatid cohesion well established, the functional significance cohesin's association with interphase chromatin not clear. Using a quantitative proteomics approach, we show that STAG1 (Scc3/SA1) subunit cohesin interacts CCTC-binding factor CTCF bound c-myc insulator element. Both allele-specific binding and Scc3/SA1 at imprinted IGF2/H19 gene locus our analyses human DM1...
As part of a long-term study in schizophrenia, model family intervention has been developed which attempts to diminish relapse rates schizophrenic patients. This reflects theoretical and research findings suggest that certain patients have "core psychological deficit" might increase vulnerability external stimuli. While program maintenance chemotherapy decreae patient vulnerability, series highly structured, supportive, psycho-educational interventions are aimed at de-intensifying the...
Abstract Mycobacterium tuberculosis (MTB) infects 30% of all humans and kills someone every 20–30 s. Here we report genome-wide binding for ~80% predicted MTB transcription factors (TFs), assayed global expression following induction each TF. The DNA-binding network consists ~16,000 events from 154 TFs. We identify >50 TF-DNA consensus motifs >1,150 promoter-binding directly associated with proximal gene regulation. An additional ~4,200 are in promoter windows represent strong...
Abstract Background The learning of global genetic regulatory networks from expression data is a severely under-constrained problem that aided by reducing the dimensionality search space means clustering genes into putatively co-regulated groups, as opposed to those are simply co-expressed . Be cause may be only across subset all observed experimental conditions, biclustering (clustering and conditions) more appropriate than standard clustering. Co-regulated also often functionally...
We present observations of the Type Ia supernovae (SNe) 1999M, 1999N, 1999Q, 1999S, and 1999U, at redshift z ≈ 0.5. They were discovered in early 1999 with 4.0 m Blanco telescope Cerro Tololo Inter-American Observatory by High-z Supernova Search Team (HZT) subsequently followed many ground-based telescopes. SNe 1999Q 1999U also observed Hubble Space Telescope. computed luminosity distances to new using two methods added them high-z diagram that HZT has been constructing since 1995. The...
Abstract Background Systems biologists work with many kinds of data, from different sources, using a variety software tools. Each these tools typically excels at one type analysis, such as microarrays, metabolic networks and predicted protein structure. A crucial challenge is to combine the capabilities (and other forthcoming) data resources create exploration analysis environment that does justice complexity systems biology sets. solution this problem should recognize types, formats in high...
Opioid receptors are major actors in pain control and broadly distributed throughout the nervous system. A challenge research is identification of key opioid receptor populations within nociceptive pathways, which physiological pathological pain. In particular, respective contribution peripheral vs. central remains unclear, it has not been addressed by genetic approaches. To investigate delta control, we created conditional knockout mice where deleted specifically NaV1.8-positive primary...
Article16 June 2009Open Access Prevalence of transcription promoters within archaeal operons and coding sequences Tie Koide Institute for Systems Biology, Seattle, WA, USAPresent address: Departamento de Bioquímica e Imunologia, Faculdade Medicina Ribeirão Preto, Universidade São Paulo, Brazil. E-mail: [email protected]Search more papers by this author David J Reiss USA Search Christopher Bare Wyming Lee Pang Marc T Facciotti Department Biomedical Engineering UC Davis Genome Center, One...
The Large Synoptic Survey Telescope (LSST) is a large-aperture, wide-field, ground-based survey system that will image the sky in six optical bands from 320 to 1050 nm, uniformly covering approximately $18,000$deg$^2$ of over 800 times. LSST currently under construction on Cerro Pachón Chile, and expected enter operations 2022. Once operational, explore wide range astrophysical questions, discovering "killer" asteroids examining nature Dark Energy. generate average 15 TB data per night,...
Opiates are powerful drugs to treat severe pain, and act via mu opioid receptors distributed throughout the nervous system. Their clinical use is hampered by centrally-mediated adverse effects, including nausea or respiratory depression. Here we used a genetic approach investigate potential of peripheral as targets for pain treatment. We generated conditional knockout (cKO) mice in which deleted specifically primary afferent Nav1.8-positive neurons. Mutant animals were compared controls...
Assess safety and efficacy of nivolumab plus nab-paclitaxel gemcitabine in patients with locally advanced/metastatic pancreatic cancer a two-part, open-label, phase I trial.Fifty chemotherapy-naive received 125 mg/m2 1,000 (days 1, 8, 15) 3 mg/kg 1 28-day cycles. The primary endpoints were dose-limiting toxicities (DLTs; part 1) grade 3/4 treatment-emergent adverse events (TEAEs) or treatment discontinuation due to TEAEs (parts 1/2). Secondary progression-free survival (PFS), overall (OS),...
We have measured the rest-frame B,V, and I-band light curves of a high-redshift type Ia supernova (SN Ia), SN 1999Q (z=0.46), using HST ground-based near-infrared detectors. A goal this study is measurement color excess, E_{B-I}, which sensitive indicator interstellar or intergalactic dust could affect recent cosmological measurements from SNe Ia. Our observations disfavor 30% opacity visual by as an alternative to accelerating Universe. This statement applies both Galactic-type (rejected at...
We present analysis of MACHO Alert 95-30, a dramatic gravitational microlensing event toward the Galactic bulge whose peak magnification departs significantly from standard point-source model. 95-30 was observed in real time by Global Microlensing Network (GMAN), which obtained densely sampled photometric and spectroscopic data throughout event. interpret light-curve "fine structure" as indicating transit lens across extended face source star. This signifies resolution star several...
Cells responding to dramatic environmental changes or undergoing a developmental switch typically change the expression of numerous genes. In bacteria, sigma factors regulate much this process, whereas in eukaryotes, four RNA polymerases and multiplicity generalized transcription (GTFs) are required. Here, by using systems approach, we provide experimental evidence (including protein-coimmunoprecipitation, ChIP-Chip, GTF perturbation knockout, measurement transcriptional these genetically...
Mycobacterium tuberculosis (MTB) is a highly successful pathogen that infects over billion people. As with most organisms, MTB adapts to stress by modifying its transcriptional profile. Remodeling of the transcriptome requires both altering transcription rate and clearing away existing mRNA through degradation, process can be directly regulated in response stress. To understand better how harsh environs human host, we performed global survey decay rates transcripts. Decay were measured for...
Facebook takes performance monitoring seriously. Performance issues can impact over one billion users so we track thousands of servers, hundreds PB daily network traffic, code changes, and many other metrics. We require latencies under a minute from events occuring (a client request on phone, bug report filed, change checked in) to graphs showing those developers' monitors. Scuba is the data management system uses for most real-time analysis. fast, scalable, distributed, in-memory database...
Opiates are potent analgesics but their clinical use is limited by side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). The produce analgesia other adverse through activation of the mu opioid receptor (MOR) encoded Oprm1 gene. However, MOR morphine metabolism involvement in OIH have been little explored. Hence, we examined contribution to comparing morphine-induced wild type (WT) knockout (KO) mice. We found that repeated administration led WT mice not KO absence...