A5051422729- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Crop Yield and Soil Fertility
- Bioinformatics and Genomic Networks
- Genetics and Plant Breeding
- Mitochondrial Function and Pathology
- Genetic Mapping and Diversity in Plants and Animals
Jilin Academy of Agricultural Sciences
2024
Université de Sherbrooke
2020-2022
RBFOX2 controls the splicing of a large number transcripts implicated in cell differentiation and development. Parsing RNA-binding protein datasets, we uncover that can interact with hnRNPC, hnRNPM SRSF1 to regulate broad range events using different sequence motifs binding modes. Using immunoprecipitation, specific RBP knockdown, RNA-seq splice-sensitive PCR, show target splice sites three configurations: single, multiple or secondary In single mode is recruited its through canonical motif,...
Serine-rich splicing factor 3 (SRSF3) was recently reported as being necessary to preserve RNA stability via an mTOR mechanism in a cardiac mouse model adulthood. Here, we demonstrate the link between Srsf3 and mitochondrial integrity embryonic cardiomyocyte-specific conditional knockout (cKO) model. Fifteen-day-old cKO mice showed dramatically reduced (below 50%) survival left ventricular systolic performance, histological analysis of these hearts revealed significant increase cardiomyocyte...
Leaf width is a key determinant of planting density and photosynthetic efficiency. In an effort to determine which genes regulate maize plant leaf width, we performed genome-wide association study (GWAS) 1.49 × 106 single nucleotide polymorphisms (SNPs) in 80 sequenced backbone inbred lines Jilin Province, China, based upon phenotypic data from two years. total, 14 SNPs were identified as being significantly related (
Abstract Background Alternative splicing can increase the diversity of gene functions by generating multiple isoforms with different sequences and functions. However, extent to which events have functional consequences remains unclear predicting impact on protein activity is limited gene-specific analysis. Results To accelerate identification functionally relevant alternative we created SAPFIR, a predictor features associated events. This webserver tool uses InterProScan predict such as...
Abstract Srsf3 was recently reported as being necessary to preserve RNA stability via an mTOR mechanism in a cardiac mouse model adulthood. Here, we demonstrate the link between and mitochondrial integrity embryonic cardiomyocyte-specific conditional knockout (cKO) model. Fifteen-day-old cKO mice showed dramatically reduced (below 50%) survival left ventricular systolic performance, histological analysis of these hearts revealed significant increase cardiomyocyte size, confirming severe...