A5091119565- Cellular transport and secretion
- Neuroscience and Neuropharmacology Research
- Lipid Membrane Structure and Behavior
- Retinal Development and Disorders
- Autism Spectrum Disorder Research
- Antimicrobial Peptides and Activities
- Neurogenesis and neuroplasticity mechanisms
- Photoreceptor and optogenetics research
- Virology and Viral Diseases
HUN-REN Institute of Experimental Medicine
2022-2024
Semmelweis University
2022-2024
Hungarian Research Network
2022
University of Jordan
2019
Pronounced differences in neurotransmitter release from a given presynaptic neuron, depending on the synaptic target, are among most intriguing features of cortical networks. Hippocampal pyramidal cells (PCs) glutamate with low probability to somatostatin expressing oriens-lacunosum-moleculare (O-LM) interneurons (INs), and postsynaptic responses show robust short-term facilitation, whereas same axons onto fast-spiking INs (FSINs) is ~10-fold higher excitatory currents (EPSCs) display...
A stunning example of synaptic diversity is the postsynaptic target cell-type-dependent difference in efficacy cortical networks. Here, we show that CA1 pyramidal cell (PC) to fast spiking interneuron (FSIN) connections have 10-fold larger release probability (Pv) than those on oriens lacunosum-moleculare (O-LM) interneurons. Freeze-fracture immunolabeling revealed different nano-topologies and coupling distances between Ca2+ channels sites (RSs) are not responsible for distinct Pv. Although...
Autism spectrum disorder (ASD) describes a range of neurodevelopmental disabilities that impair behavior and communication. Although it is relatively prevalent, the pathophysiology still subject to speculation debate. The aim this study identify possible association between interleukin-6, -8, -9, -10 tumor necrosis factor alpha (TNF-α) in autism among Jordanian children by comparing plasma levels these cytokines autistic with those their unaffected siblings unrelated healthy controls.In...
Selective distribution of proteins in presynaptic active zones (AZs) is a prerequisite for generating postsynaptic target cell type-specific differences vesicle release probability (Pv) and short-term plasticity, characteristic feature cortical pyramidal cells (PCs). In the hippocampus rodents, somatostatin mGluR1α expressing interneurons (mGluR1α+ INs) receive small, facilitating excitatory currents (EPSCs) from PCs express Elfn1 that trans-synaptically recruits mGluR7 into AZ PC axons....