A5037585820- Malaria Research and Control
- Mosquito-borne diseases and control
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Reproductive Biology and Fertility
- Trypanosoma species research and implications
- Cancer-related molecular mechanisms research
- Vibrio bacteria research studies
- Complement system in diseases
- Genomics and Chromatin Dynamics
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- Mycobacterium research and diagnosis
- Renal and related cancers
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Advanced Electron Microscopy Techniques and Applications
- Lipid Membrane Structure and Behavior
- Herpesvirus Infections and Treatments
The University of Melbourne
2021-2023
Walter and Eliza Hall Institute of Medical Research
2018-2023
Imperial College London
2021
Medical Research Council
2015-2016
MRC Laboratory of Molecular Biology
2015-2016
Centre National de la Recherche Scientifique
2013
Institut Curie
2013
Abstract The most severe form of malaria is caused by Plasmodium falciparum . These parasites invade human erythrocytes, and an essential step in this process involves the ligand PfRh5, which forms a complex with cysteine-rich protective antigen (CyRPA) PfRh5-interacting protein (PfRipr) (RCR complex) binds basigin on host cell. We identified heteromeric disulfide-linked consisting P. thrombospondin-related apical merozoite (PfPTRAMP) small secreted (PfCSS) have shown that it RCR to...
The equalization of pericentric heterochromatin from distinct parental origins following fertilization is essential for genome function and development. recent implication noncoding transcripts in this process raises questions regarding the connection between RNA nuclear organization chromatin environments. Our study addresses interrelationship replication transcription two (PHC) domains their reorganization during early embryonic We demonstrate that PHC dispensable its clustering at late...
Abstract Host membrane remodeling is indispensable for viruses, bacteria, and parasites, to subvert the barrier obtain entry into cells. The malaria parasite Plasmodium spp . induces biophysical molecular changes erythrocyte through ordered secretion of its apical organelles. To understand this process address debate regarding how parasitophorous vacuole (PVM) formed, we developed an approach using lattice light-sheet microscopy, which enables interaction with host cell be tracked...
Once every menstrual cycle, eggs are ovulated into the oviduct where they await fertilization. The arrested in metaphase of second meiotic division, and only complete meiosis upon It is crucial that maintenance arrest tightly controlled, because spontaneous activation egg would preclude development a viable embryo (Zhang et al. 2015 J. Genet. Genomics 42 , 477–485. ( doi:10.1016/j.jgg.2015.07.004 ); Combelles 2011 Hum. Reprod. 26 545–552. doi:10.1093/humrep/deq363 Escrich Assist. 28 111–117....
Abstract Plasmodium falciparum causes the most severe form of malaria in humans. The protozoan parasite develops within erythrocytes to mature schizonts, that contain more than 16 merozoites, which egress and invade fresh erythrocytes. aspartic protease plasmepsin X (PMX), processes proteins proteases essential for merozoite from schizont invasion host erythrocyte, including leading vaccine candidate PfRh5. PfRh5 is anchored surface through a 5-membered complex (PCRCR), consisting...
Malaria remains a major burden world-wide, but the disease-causing parasites from genus Plasmodium are difficult to study in vitro. Owing small size of parasites, subcellular imaging poses challenge and use super-resolution techniques has been hindered by parasites' sensitivity light. This is particularly apparent during blood-stage life cycle, which presents an important target for drug research. The iron-rich food vacuole parasite undergoes disintegration when illuminated with high-power...
Cell division in mammalian cells is regulated by Aurora kinases. The activity of A indispensable for correct function centrosomes and proper spindle formation, while B chromosome biorientation separation. also responsible the phosphorylation histone H3 serine 10 (H3S10Ph) from G2 to metaphase. Data concerning H3S10Ph embryonic are limited primordial maturing oocytes advanced pronuclei zygotes. In present study we have analyzed 1- 2-cell mouse embryos. We show that H3S10 remains...
Abstract RhopH complexes consists of Clag3, RhopH2 and RhopH3 are essential for growth Plasmodium falciparum inside infected erythrocytes. Proteins released from rhoptry organelles during merozoite invasion trafficked to the surface erythrocytes enable uptake nutrients. RhopH3, unlike other proteins, is required parasite invasion, suggesting some cellular processes proteins function as single players rather than a complex. We show complex has not formed invasion. Clag3 directly into host...
Abstract Plasmodium falciparum causes the most severe form of malaria in humans. The protozoan parasite develops within erythrocytes to mature schizonts, that contain more than 16 merozoites, which egress and invade fresh erythrocytes. aspartic protease plasmepsin X (PMX), processes proteins proteases essential for merozoite from schizont invasion host erythrocyte, including leading vaccine candidate PfRh5. PfRh5 is anchored surface through a 5-membered complex (PCRCR), consisting...