A5039953190- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Mitochondrial Function and Pathology
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Cholinesterase and Neurodegenerative Diseases
- Tryptophan and brain disorders
- Traumatic Brain Injury Research
- Advanced Neuroimaging Techniques and Applications
- Coenzyme Q10 studies and effects
- Inflammatory mediators and NSAID effects
- Prion Diseases and Protein Misfolding
- Molecular Communication and Nanonetworks
- Cardiac Arrest and Resuscitation
- Natural product bioactivities and synthesis
- Medicinal Plants and Neuroprotection
- Computational Drug Discovery Methods
- Connexins and lens biology
- Protein Structure and Dynamics
- Neural dynamics and brain function
- Biochemical effects in animals
KU Leuven
2016-2023
VIB-KU Leuven Center for Brain & Disease Research
2019-2022
A physiological function for sAPP? Although the pathological role of amyloid-β precursor protein (APP) in Alzheimer's disease is well studied, this has remained elusive. Rice et al. found that secreted ectodomain APP (sAPP) binds to GABA B R1a, metabotropic receptor inhibitory neurotransmitter γ-aminobutyric acid (GABA) (see Perspective by Korte). Binding suppressed synaptic vesicle release and modulated transmission plasticity mice. short, 17–amino peptide bound R1a's sushi 1 domain,...
The hippocampus is important for spatial navigation, episodic memory and affective behaviour. Increasing evidence suggests that these multiple functions are accomplished by different segments along the dorsal-ventral (septal-temporal) axis. Long-term potentiation (LTP), best-investigated cellular correlate of learning memory, has distinct properties this axis in CA1 region, but so far, little known about longitudinal differences dentate gyrus (DG). Therefore, here we examined potential...
Neurocognitive disorders, among which Alzheimer's disease (AD), have become one of the major causes death in developed countries. No effective disease-modifying therapy is available, possibly because current treatments are administered too late to still be able intervene progress. AD characterized by a gradual onset with subclinical neurobiological and behavioral changes that precede diagnosis years even decades. The earlier diagnosis, potential can tested started. Mouse models valuable...
Abstract Background Hyperphosphorylation and intraneuronal aggregation of the microtubule-associated protein tau is a major pathological hallmark Alzheimer’s disease (AD) brain. Of special interest effect cerebral amyloid beta deposition, second main AD, on human pathology. Therefore, studying influence amyloidosis in novel knock-in (htau-KI) mouse model could help to reveal new details their interplay. Methods We studied effects htau-KI under fast-progressing 5xFAD mice terms correlation...
Background: Traumatic brain injury (TBI), even single-impact mild TBI (mTBI), is associated with increased risk of neuronal damage and neurodegeneration, leading to dementia, in particular Alzheimer's disease (AD). The tell-tale histopathological defects AD, deposits amyloid protein tau are observed following TBI. However, little known about the mechanisms underlying association, its impact on synaptic plasticity. Objectives: This study aimed analyze whether mTBI alters or accelerates...
Ionising radiation (IR) is a cause of lipid peroxidation, and epidemiological data have revealed correlation between exposure to IR the development eye lens cataracts. Cataracts remain leading blindness around world. The plasma membranes fibre cells are one most cholesterolrich in human body, forming rafts contributing biophysical properties membrane. Liquid chromatography followed by mass spectrometry was used analyse bovine membrane fractions after 5 50 Gy lenses taken from wholebody 2...
Event Abstract Back to Optogenetic inhibition of long-term potentiation in the mouse dentate gyrus An Schreurs1, Nele Leenders1, Victor Sabanov1, Chris Van Den Haute2, Marleen Welkenhuysen3, Luis Hoffman3, Dries Braeken3, Veerle Baekelandt2 and Detlef Balschun1* 1 KU Leuven, Faculty Psychology Educational Sciences, Brain & Cognition, Laboratory Biological Psychology, Belgium 2 Department Neurosciences, Neurobiology Gene Therapy, 3 imec, Life Science Technologies Department, The hippocampus...
Event Abstract Back to Amyloid aggravates tauopathy: stronger deficits in hippocampal and prefrontal neuroplasticity fear memory APP.V717IxTau.P301L vs. Tau.P301L mice Amira Latif-Hernandez1*, An Schreurs1, Tariq Ahmed2, Fred Van Leuven3, Rudi D'Hooge1 Detlef Balschun1 1 Katholieke Universiteit Leuven, Brain Cognition, Belgium 2 Qatar Biomedical Research Institute, Neurological Disorder Center, 3 KU Department of Human Genetics, Alzheimer’s disease is a neurodegenerative disorder...
Translation of novel therapies against Alzheimer's Disease (AD) into human patients has proven to be challenging, even though preclinical studies in mice frequently showed a disease modifying effect. Therefore, current mouse models are not fully representative for AD pathology. Here, we have generated wild-type tau knock-in model by whole gene replacement and characterized these the high-amyloid background 5xFAD mice. The htau-KI was cross-bred with model, which shows severe AD-related...