A5103026453- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Biofuel production and bioconversion
- Plant-Microbe Interactions and Immunity
- Electrochemical sensors and biosensors
- Drug-Induced Hepatotoxicity and Protection
- COVID-19 Clinical Research Studies
- Microbial Metabolic Engineering and Bioproduction
- Enzyme Catalysis and Immobilization
- Metal complexes synthesis and properties
- Drug Transport and Resistance Mechanisms
- Plant Disease Resistance and Genetics
- Diabetes Treatment and Management
- Plant Pathogens and Resistance
- bioluminescence and chemiluminescence research
- COVID-19 and healthcare impacts
- Protein Interaction Studies and Fluorescence Analysis
- Mast cells and histamine
- Microbial Fuel Cells and Bioremediation
- Cassava research and cyanide
- Cholinesterase and Neurodegenerative Diseases
- biodegradable polymer synthesis and properties
- GABA and Rice Research
- Spectroscopy and Quantum Chemical Studies
- Fungal Plant Pathogen Control
Jilin Academy of Agricultural Sciences
2025
Nanjing Agricultural University
2021-2024
General Hospital of Shenyang Military Region
2020-2021
Jinzhou Medical University
2020-2021
Peking Union Medical College Hospital
2019
Northwest A&F University
2019
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
China Agricultural University
2018-2019
University Medical Centre Mannheim
2019
Heidelberg University
2019
Summary Oomycete pathogens secrete numerous effectors to manipulate host immunity. While some share a conserved structural fold, it remains unclear if any have targets. Avr3a‐like family effectors, which are related Phytophthora infestans effector PiAvr3a and widely distributed across diverse clades of species, were used study this question. By using yeast‐two‐hybrid, bimolecular fluorescence complementation co‐immunoprecipitation assays, we identified members the plant cinnamyl alcohol...
Ditylenchus destructor, commonly known as the potato rot nematode, is a significant plant-parasitic pathogen affecting over 120 plant species globally. Effective control measures for D. destructor are limited, underscoring need high-quality reference genome to understand its pathogenic mechanisms. Herein, we combined Illumina short reads, PacBio long and Hi-C mapping technology construct chromosome-scale assembly destructor. The totals 133.86 Mb, with 129.51 Mb (96.74%) of sequences anchored...
Lipid metabolism is often disrupted in liver cirrhosis. The present study aimed to evaluate the impact of lipid profile on decompensation events, severity dysfunction, and death patients with cirrhosis.In a cross-sectional study, 778 data were enrolled, then divided into 240 538 without cirrhosis, respectively. In cohort 314 cirrhotic data, who prospectively followed, enrolled. included total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), low-density (LDL-c), triglycerides...
Dihydrofolate reductase (DHFR) is an essential enzyme in the folate pathway and has been recognized as a well-known target for antibacterial antifungal drugs. We discovered eight compounds from ZINC database using virtual screening to inhibit Rhizoctonia solani (R. solani), fungal pathogen crops. These were evaluated with vitro assays enzymatic activity. Among these, compound Hit8 most active R. DHFR inhibitor, IC50 of 10.2 μM. The selectivity inhibition 22.3 against human 227.7 Moreover,...
Abstract β-1,3-glucanase can specifically hydrolyze glucans to oligosaccharides and has potential applications in biotechnology. We used the metatranscriptomic technology discover a thermophilic from compost. The phylogenetic study shows that it belongs family 16 glycoside hydrolase (GH16) is most homologous with an enzyme Streptomyces sioyaensis , actinobacterium. It activity of 146.9 U/mg optimal reaction condition (75 °C pH 5.5). Its catalytic domain was crystallized diffracted 1.14 Å...
β-N-acetyl-D-hexosaminidases have attracted significant attention due to their crucial role in diverse physiological functions including antibacterial synergists, pathogen defense, virus infection, lysosomal storage, and protein glycosylation. In particular, the GH3 β-N-acetyl-D-hexosaminidase of V. cholerae (VcNagZ), human GH20 B (HsHexB), GH84 (hOGA) are three important representative glycosidases. These been found be implicated β-lactam resistance storage disorders (HsHexB) Alzheimer's...
Cirrhotic patients who were consecutively hospitalized between January 2016 and March 2019 screened. Serum cardiac biomarkers at admission, including N-Terminal pro-B-type natriuretic peptide (NT-pro BNP), high-sensitivity troponin T (hs-cTnT), creatine kinase (CK), MB (CK-MB), lactate dehydrogenase (LDH), collected. Acute decompensating events primarily ascites, acute gastrointestinal hemorrhage, acute-on-chronic liver failure (ACLF), recorded.The NT-pro BNP level was significantly higher...
Tobacco black shank, caused by Phytophthora parasitica, is one of the most notorious tobacco diseases and causes huge economic losses worldwide. Understanding genetic variation P. parasitica populations essential to development disease control measures. In this research, 210 simple sequence repeat (SSR) markers for were identified, 10 which polymorphic among nine reference strains. We further performed population analysis 245 isolates randomly collected from fields in Chongqing mating type,...
Background: Anemia is one of the most common disorders in world. Serum iron an essential element for synthesis hemoglobin and contribution oxygen-carrying ability red blood cells (RBCs). Iron sucrose injection may effectively correct deficiency, increase storage, then improve anemia. The aim present study was to evaluate therapeutic effect anemia patients with reduced serum concentration. Methods: Overall, 95 digestive and/or liver diseases were included. They divided according infusion...