A5100699495- Water Systems and Optimization
- Geotechnical Engineering and Underground Structures
- High voltage insulation and dielectric phenomena
- Water Treatment and Disinfection
- Geophysical Methods and Applications
- Robotics and Sensor-Based Localization
- Media Studies and Communication
- Indoor and Outdoor Localization Technologies
- Underwater Vehicles and Communication Systems
- Mechanical stress and fatigue analysis
- Urban Stormwater Management Solutions
- Non-Destructive Testing Techniques
- Cultural Industries and Urban Development
- Water Quality Monitoring Technologies
- Energy Efficiency and Management
- Software Engineering Research
- Plant Stress Responses and Tolerance
- Lipoproteins and Cardiovascular Health
- Canadian Identity and History
- Cancer, Lipids, and Metabolism
- Cardiovascular Function and Risk Factors
- Water Governance and Infrastructure
- Biomarkers in Disease Mechanisms
- Machine Learning and Data Classification
- Wastewater Treatment and Nitrogen Removal
Wellcome Centre for Cell-Matrix Research
2024-2025
University of Manchester
2024-2025
Manchester Academic Health Science Centre
2024-2025
University of Sheffield
2015-2024
UNSW Sydney
2020
City, University of London
2017
Liverpool John Moores University
2017
Wellcome Sanger Institute
2016
Pennine Care NHS Foundation Trust
2014
Academy of Media Arts Cologne
2013
Pentraxin-3 (PTX3) is an octameric protein, comprised of eight identical protomers, that has diverse functions in reproductive biology, innate immunity and cancer. PTX3 interacts with the large polysaccharide hyaluronan (HA) to which heavy chains (HCs) inter-α-inhibitor (IαI) family proteoglycans are covalently attached, playing a key role (non-covalent) crosslinking HC•HA complexes. These interactions stabilise cumulus matrix, essential for ovulation fertilisation mammals, also implicated...
Within drinking water distribution systems (DWDS), microorganisms form multi-species biofilms on internal pipe surfaces. A matrix of extracellular polymeric substances (EPS) is produced by the attached community and provides structure stability for biofilm. If EPS adhesive strength deteriorates or overcome external shear forces, biofilm mobilised into potentially leading to degradation quality. However, little known about within DWDS how this influenced composition environmental parameters,...
In this article, we describe an unmanned aerial system equipped with a thermal-infrared camera and software pipeline that have developed to monitor animal populations for conservation purposes. Taking multi-disciplinary approach tackle problem, use freely available astronomical source detection the associated expertise of astronomers, efficiently reliably detect humans animals in footage. Combining existing machine learning algorithms into single, automated, end-to-end pipeline, test using...
It has been hypothesized that negative pressures caused by transients within water distribution systems may result in ingress of contaminated groundwater through leaks and hence pose a risk to public health. This paper presents results contaminant experiments from novel laboratory facility at The University Sheffield. An engineered leak surrounded porous media was subjected pressure resulting the rapid closure an upstream valve. shown pollutant originating externally drawn transported end...
Leakage from water distribution pipes is a problem worldwide, and are commonly detected using the Vibro-Acoustic Emission (VAE) produced by leak. The ability to quantify leak flow rate VAE would have economic operational benefits. However complex interaction between variables leak's signal make classification of difficult therefore there has been lack research in this area. aim study use monitoring investigate processing techniques that rate. A number alternative deployed evaluated,...
The hydraulics of leakage and intrusion flows through leak openings in pipes is complicated by variations the areas owing to changes pressure. This paper argues that pressure–area relationship can reasonably be assumed a linear function, modified orifice equation proposed for more realistic modeling flows. properties are explored different classes openings. implications current practice using power model then investigated. A mathematical proof an linking parameters equations concept...
Journal Article Three-year follow-up of the Oxford Cholesterol Study: assessment efficacy and safety simvastatin in preparation for a large mortality study Get access A. KEECH, KEECH *MRC/ICRF Clinical Trial Service Unit, Nuffield Department MedicineRadcliffe Infirmary, Oxford†Department CardiologyJohn Radcliffe Hospital, Coresspondence: Study, MRC/ICRF Harkneas Building, Infinnary, OX2 6HE, U.K. Search other works by this author on: Academic PubMed Google Scholar R. COLLINS, COLLINS S....
ABSTRACT Pentraxin-3 (PTX3) is an octameric protein, comprised of eight identical protomers, that has diverse functions in reproductive biology, innate immunity and cancer. PTX3 interacts with the large polysaccharide hyaluronan (HA) to which heavy chains (HCs) inter-α-inhibitor (IαI) family proteoglycans are covalently attached, playing a key role (non-covalent) crosslinking HC•HA complexes. These interactions stabilise cumulus matrix, essential for ovulation fertilisation mammals, also...
This article discusses how pipeline networks that experience sudden pressure differences, even in the absence of initial system flow, can create severe transient pressures. If a pipe is under static and valve suddenly opened, depressurization wave propagates through system. As with any transient, reflection based on material, at dead end original reflected waves superimpose. superposition almost invariably large enough for local pressures to drop below gauge value reach vacuum pressures,...
This paper presents a new, tractable analytical expression to describe the intrusion of fluids into buried pipes under steady-state conditions. The is validated with results from novel experiments. derivation based on combination relevant existing models flows through porous media and losses an orifice, resulting relating flow rate applied driving pressure. shown yield directly equivalent those generated full three-dimensional (3D) computational fluid dynamics (CFD) model process. Results...
The erosion of the cohesive layers particulate matter that causes discolouration in water distribution system mains has previously been modelled using Prediction Discolouration Distribution Systems (PODDS) model. When first proposed, PODDS featured an unvalidated means by which material regeneration on pipe walls could be simulated. Field and laboratory studies have yielded data suggest formulations incorrectly model these processes. A new is proposed to overcome this shortcoming. It tracks...
Sustainable urban infrastructure planning and maintenance require an integrated approach that considers various assets (e.g., the ground, roads, buried pipes) their inter-linkages as a holistic system. To facilitate usage of this approach, we propose model city interdependencies, providing details on how asset properties processes affect each other. This is represented ontologies in OWL 2 Web Ontology Language Manchester Syntax, which can be read interpreted by machines automatically. These...
The common existence of pressure transients in operational water distribution systems (WDS) requires their characterisation and assessment impact. This paper performs such by evidencing the occurrence differences transient behaviour complex WDS. Ten samples continuously recorded high resolution pressures from diverse networks sources were analysed. presented traces show regular occasional waves various networks. Histogram analysis rate change head provides some insight into these sites....
Leakage from water distribution systems is a worldwide issue with consequences including loss of revenue, health and environmental concerns. Leaks have typically been found through leak noise correlation by placing sensors either side the recording analysing its vibro-acoustic emission. While this method widely used to identify location leak, also record data that could be related leak’s flow rate, yet no reliable exists predict rate in pipes using The aim research medium-density...
Abstract Water loss from leaking pipes represents a substantial of revenue as well environmental and public health concerns. Leak location is normally identified by placing sensors either side the leak recording analysing noise. The noise contains information about leak's characteristics, including its shape. Whilst tool which non-invasively provides shape would be useful for water industry practitioners, no currently exists. This study evaluates effect various shapes on vibration signal...
Effective leakage models are crucial for assessment and control strategies to improve the sustainability of vital water distribution, other pipeline, infrastructure. This paper evaluates interdependence leak hydraulics, structural dynamics soil particularly considering significance conditions external longitudinal slits in viscoelastic pipe. Initial numerical exploration unique physical experimental results presented exploring this complex phenomenon. The existence an idealised fully...
Strategies for managing leakage from water distribution systems require the ability to effectively evaluate such real losses through understanding of behavior individual leaks, including their response changes in pressure regime due demand or management strategies. This paper presents results an innovative experimental investigation aimed at longitudinal slits pressurized viscoelastic pipes, specifically considering interaction between structural and dynamics. For first time, flow rate,...
Fatigue cracking is thought to be a critical failure mode for Grey Cast Iron (GCI) water pipes; however, this mechanism poorly understood. Using novel approach sourcing GCI pipe material testing, the variation in fatigue strength between pipes from same batch was experimentally quantified. These results were used assess impact of on hypothetical but realistic years-to-failure scenario. Full-pipe sections during testing and observed gave physical meaning years-to-fatigue-failure predictions...
Grey Cast Iron (GCI) water pipes are subject to multiaxial, cyclic stresses caused by combinations of loads such as internal pressure and road vehicle weight. However, the multiaxial fatigue performance this material has not previously been characterised. To address gap more than 45 tests, including some under non-proportional tension-torsion loading, were completed using a GCI very similar pipe GCI. Of four criteria tested, Smith-Watson-Topper (SWT) criterion provided best predictions...
Pipelines in potable water distribution system are a vital part of modern infrastructure, providing one the most important services for society. This vital, complex infrastructure is endemic to our urban environments but ageing, with current average age around 70 years and replacement rates an inferred serviceable asset life hundreds years. Hence it that we develop technology will enable pipeline condition assessment without service interruption. Due environmental operational stresses acting...
Water is a highly valuable resource so asset management of associated infrastructure critical importance. distribution pipe networks are usually buried, and difficult to access. Robots therefore appealing for performing inspection detecting damage target repairs. However, robot mapping localisation buried water pipes has not been widely investigated date, challenging because tend be relatively featureless. In this paper we propose algorithm metal with two key novelties: the development new...
One of the most fundamental tasks for robots inspecting water distribution pipes is localization, which allows autonomous navigation, faults to be communicated, and interventions instigated. Pose-graph optimization using spatially varying information used enable localization within a feature-sparse length pipe. We present novel method improving estimation robot’s trajectory measured acoustic field, applicable other measurements such as magnetic field sensing. Experimental results show that...