A5045682218- Immune Cell Function and Interaction
- 3D Printing in Biomedical Research
- Reproductive tract infections research
- Traumatic Brain Injury Research
- Cancer Cells and Metastasis
- Viral-associated cancers and disorders
- Mesenchymal stem cell research
- Immune Response and Inflammation
- Tissue Engineering and Regenerative Medicine
- Blood disorders and treatments
- interferon and immune responses
- RNA Interference and Gene Delivery
- Neurogenetic and Muscular Disorders Research
- Cellular Mechanics and Interactions
- Eosinophilic Disorders and Syndromes
- T-cell and B-cell Immunology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Influenza Virus Research Studies
- Neonatal Respiratory Health Research
- Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Reproductive System and Pregnancy
- Cancer Research and Treatments
- Emergency and Acute Care Studies
- Cervical Cancer and HPV Research
Memorial University of Newfoundland
2022-2023
Shriners Hospitals for Children - Erie
2014-2016
Harvard University
1990-2016
Massachusetts General Hospital
2014-2016
Shriners Hospitals for Children - Boston
2014-2016
Brigham and Women's Hospital
2012-2015
University of North Carolina at Chapel Hill
1988-1991
Cancer Research UK Clinical Trials Unit
1987
University of Birmingham
1987
Latent Epstein-Barr virus (EBV) infection and growth transformation of B lymphocytes is characterized by EBV nuclear membrane protein expression (EBV antigen [EBNA] latent [LMP], respectively). LMP1 known to be an oncogene in rodent fibroblasts induce B-lymphocyte activation cellular adhesion molecules the EBV-negative Burkitt's lymphoma cell line Louckes. EBNA-2 required for EBV-induced transformation; it lowers fibroblast serum dependence specifically induces CD23 Louckes cells. These...
Wide-spread protozoan parasites carry endosymbiotic dsRNA viruses with uncharted implications to the human host. Among them, Trichomonas vaginalis, a parasite adapted genitourinary tract, infects globally ∼250 million each year rendering them more susceptible devastating pregnancy complications (especially preterm birth), HIV infection and HPV-related cancer. While first-line antibiotic treatment (metronidazole) commonly kills pathogen, it fails improve reproductive outcome. We show that...
Infusion of lymph node–derived fibroblastic reticular cells into septic mice increases survival at late time points after disease onset.
Transient cell therapy is an emerging drug class that requires new approaches for pharmacological monitoring during use. Human mesenchymal stem cells (MSCs) are a clinically-tested transient therapeutic naturally secrete anti-inflammatory factors to attenuate immune-mediated diseases. MSCs were used as proof-of-concept with the hypothesis measuring release of secreted after transplantation, rather than biodistribution alone, would be alternative tool understand exposure subject MSCs. By...
Abstract Cancer-associated fibroblasts (CAFs) are a major cancer-promoting component in the tumor microenvironment (TME). The dynamic role of human CAFs cancer progression has been ill-defined because lack unique marker needed for cell-specific, promoter-driven knockout model. Here, we developed an engineered CAF cell line with inducible suicide gene to enable selective vivo elimination at different stages xenograft development, effectively circumventing challenge targeting cell-specific...
Class I molecules of the MHC bind foreign and endogenous peptides allowing recognition by TCR on CTL. The killing cells infected with lymphocytic choriomeningitis virus (LCMV) depends LCMV bound to class MHC. Mutations in have enabled delineation regions molecule important for binding interaction TCR. We constructed a library mutants using saturation mutagenesis report phenotypic change resulting from single amino acid substitution that results heteroclitic (increased) LCMV-infected cells....
The interactive association between T lymphocytes and their target cells is an important system of cell-cell interactions. Major histocompatibility complex class I molecules are the cell surface structures recognized by cytolytic lymphocytes. To define molecular cytotoxic lymphocytes, we have saturated 270-base-pair alpha 1 exon H-2Dp gene with point mutations, rapidly producing a "library" 2.5 x 10(3) independent mutants. library contains enough recombinant clones (each clone encoding...
Objective: The objective of this paper is to outline key principles required for a knowledge translation (KT) strategy on concussion education medical trainees and physicians promote retention practice change. Design: Qualitative review the literature utilizing Canadian Institute Health Research (CIHR) Knowledge Action (KTA) Cycle as framework. Results: Medical appears be increasing, but many gaps persist. Although guidelines standardized assessments have been developed, are either not aware...
Background: Research has shown that concussion education in a proportion of Canadian medical school curriculums is lacking. The objective this study was to measure knowledge among trainees, while comparing the impact lecture-based and clinical learning on their scores. Methods: A validated survey distributed MS1, MS2, MS3, MS4 students, as well post-graduate learners family medicine, pediatrics, emergency medicine. Results: Participants with experience (MS3 + Residents) scored significantly...