A5017653834- Nanoplatforms for cancer theranostics
- Photochromic and Fluorescence Chemistry
- Nanoparticle-Based Drug Delivery
- Nanocluster Synthesis and Applications
- Luminescence and Fluorescent Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- X-ray Diffraction in Crystallography
- Dendrimers and Hyperbranched Polymers
- Crystallization and Solubility Studies
- Antioxidant Activity and Oxidative Stress
- Cancer therapeutics and mechanisms
- Polydiacetylene-based materials and applications
- RNA Interference and Gene Delivery
- Nonlinear Optical Materials Studies
- Advanced Polymer Synthesis and Characterization
- Advanced biosensing and bioanalysis techniques
- Synthesis and Properties of Aromatic Compounds
- Radiation Detection and Scintillator Technologies
- Metal complexes synthesis and properties
- Click Chemistry and Applications
- Quantum Dots Synthesis And Properties
- Porphyrin and Phthalocyanine Chemistry
- Organic Light-Emitting Diodes Research
- Moringa oleifera research and applications
- Atmospheric Ozone and Climate
Japan Agency for Marine-Earth Science and Technology
2018-2024
Tohoku University
2014-2024
Sendai National College of Technology
2024
National Institute of Technology
2024
Advanced Institute of Materials Science
2022
Sendai University
2018-2020
Graduate School USA
2018
Naval Hospital Yokosuka Japan
2018
Abstract Controlling or switching the optical signal from a large collection of molecules with minimum photons represents an extremely attractive concept. Promising fundamental and practical applications may be derived such photon‐saving principle. With this aim in mind, we have prepared fluorescent photochromic organic nanoparticles (NPs), showing bright red emission, complete ON–OFF contrast full reversibility, excellent fatigue resistance. Most interestingly, upon successive UV visible...
SNC4DC, a dimer of SN-38 derivatives, has been synthesized. SNC4DC nanoparticles called nano-prodrugs are internalized into the cell and dissociate, active is released after reduction S–S bond in presence GSH occurs.
We developed prodrug nanoparticles that release drugs through intracellular dissolution and a cancer-specific hydrogen peroxide response. To reveal the unclear mechanism regarding drug from by reacting with in cancer cells, this study demonstrates
Controlling or switching the optical signal from a large collection of molecules with minimum photons represents an extremely attractive concept. Promising fundamental and practical applications may be derived such photon-saving principle. With this aim in mind, we have prepared fluorescent photochromic organic nanoparticles (NPs), showing bright red emission, complete ON–OFF contrast full reversibility, excellent fatigue resistance. Most interestingly, upon successive UV visible light...
Iridium-hydrido complexes bearing a hemilabile silyl-pyridine-amine pincer ligand were synthesised. They found to catalyse Si-H deuteration of trialkylsilanes with excess benzene-d6 in 99-94% conversion at room temperature through C-D bond activation and H/D exchange.
Carotenoids are increasingly used as naturally occurring food colorants. For application beverage colorants, fat-soluble carotenoids formulated into dispersion systems via nanoparticle (NP) formation. In recent years, the antioxidant properties of have gained immense recognition for their preventive health benefits, thereby highlighting further interest in development functional ingredients. Although dispersion-based formulations desirable, knowledge regarding structural and optical NPs...
Abstract As an exceptional carrier for localized drug delivery to tumors, hydrogels can achieve prolonged release through careful design and adjustments, effectively targeting cancer cells minimizing side effects. This study investigates a novel dual‐responsive hydrogel system designed the of nanomedicines, focusing on local antitumor efficacy SN‐38‐cholesterol nanoparticles (SN‐38‐chol NPs) polydopamine NPs (PDA NPs)/poly(n‐isopropylacrylamide) (pNIPAM) hydrogels. By combining...
We have successfully fabricated fluorescent [Cu(μ-Br)dppb]2 nanoparticles by developing the heterogeneous reaction process. The fluorescence peak position of resulting was redshifted ca. 20 nm from that bulk crystal. In addition, crystallinity and quantum yield were improved adopting a suitable annealing treatment.
The development of pure nanodrugs (PNDs) has led to the possibility delivering anticancer agents without involving nanocarriers. On path its clinical application, dispersion stability PNDs must be improved. In present study, we tried improve ester-linked SN-38 dimer by surface modification with coordination complexes between tannic acid (TA) and metal ions. TA FeIII coated (TA-Fe/PNDs) showed superior colloidal as they did not show aggregation, comparing non-coated PNDs. It was also found...
We have successfully fabricated insoluble copper(I) complex [Cu(μ-I)dppet]2 nanocrystals by developing the heterogeneous reaction process between rod-like of dppet ligand prepared in advance and added acetonitrile solution halide. During this process, shape was dramatically changed from to spherical. Probably, complexation subsequent nanocrystallization would proceed on or near swollen surface droplet as restricted field.
We have successfully fabricated insoluble polymer-metal complex [{Cu2(µ-Br)2(PPh3)2}(µ-bpy)]n (bpy = 4, 4′-bipyridine) nanocrystals by developing already-established heterogeneous reaction process, which clearly show luminescence in solid state. Photochromic azopyridine was also adsorbed and modified on the surface of through applying improved process. Interestingly, obtained azopyridine-modified emitted photoresponsive fluorescence alternative photoisomerization surface.
Abstract Azulene derivatives such as guaiazulene have unique properties and thus play important roles in electronic materials. However, the application of these materials is limited by lack functionalization approaches for extracted from natural products. Herein, we report a method synthesis three carboxylic acid four to five steps controlling reactivity guaiazulene. 7-Isopropyl-4-methylazulene-1-carboxylic was prepared protecting C-3 position with an ester group inhibit unexpected...
Tuning the conformations of flexible molecules has recently shown promise as a strategy for creating new materials. However, creation soft-molecule materials remains challenging because these are typically characterized without fully considering contribution molecular distortion. Carotenoids flexible, polyene-based that prone to distortion, which not yet been considered factor controls their optical properties; rather, it only explained via simulations causing differences in arrangements....
Safety concerns in the food industry have increased demand for natural colorants. However, application ranges of blue colorants are insufficient because they scarce nature, and currently available dyes limited to water-soluble products. In this study, we investigated a fat-soluble azulene derivative isolated from mushroom Lactarius indigo as potential candidate colorant. We developed its first total synthesis, where skeleton was constructed pyridine an ethynyl group converted into...
We have successfully visualized the surface terminal structure of polymer-metal complex [{Cu2(μ-Br)2(PPh3)2}(μ-bpy)] n nanocrystals (NCs) using Prussian blue (PB) nanoparticles (NPs). From TEM observation and analysis electron beam diffraction pattern, it was found that (010) plane had grown well, ends main chains would be located on present NCs as a dangling bond. Actually, PB NPs were selectively adsorbed NCs. This fact clearly means bipyridine ligands having nitrogen-terminal coordinate...
It has been difficult to selectively modify the surface of molecular crystals by chemical reactions because they usually have no reaction points on their surfaces. In this paper, focusing unique nanocrystal polymer metal complex (PMC) [{Cu2(μ-Br)2(PPh3)2}(μ-bpy)] n having an exposed reactive terminal chain, we successfully modified PMC nanocrystals (NCs) through alkylation reaction. Interestingly, after reaction, luminescence spectrum NCs blue-shifted, and quantum yield increased. with a...
Photoschaltbare fluoreszierende Nanopartikel mit verbesserter Leistung dank eines effizienten intermolekularen Energietransfers sind das Thema der Zuschrift auf S. 3726 ff. von T. Fukaminato, R. Métivier et al. Die Halbkugel zeigt ein aufgeschnittenes (NP) aus fluoreszierenden photochromen Molekülen (grau und rot). Bestrahlung wenigen Photonen induziert eine Reaktion (NP im Vordergrund), bei einige photochrome Moleküle in den gelöschten Zustand (blau) übergehen; durch Energietransfer (weiße...
難溶性錯体をナノ結晶化する手法「ナノ固相反応法」を独自に開発し，発光性錯体［Cu（μ-Br）dppb］2ナノ結晶の作製に成功した。得られた［Cu（μ-Br）dppb］2ナノ結晶の蛍光極大波長は，室温においてバルク結晶よりも長波長シフトした。この挙動は，バルク結晶よりも安定な立体配座に起因するものと考察した。さらに，［Cu（μ-Br）dppb］2錯体ナノ結晶粒子の発光特性の温度依存性を検討したところ，液体窒素温度からの温度上昇にともない，蛍光極大波長の短波長シフトかつ蛍光強度の増大を観測した。ナノ結晶化による一重項励起状態と三重項励起状態間のエネルギー差および逆項間交差の制御により，遅延蛍光とリン光を基としたナノ結晶特有の光学特性を見いだした。