A5032126841- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Neonatal Respiratory Health Research
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Cytokine Signaling Pathways and Interactions
- Wound Healing and Treatments
- Trace Elements in Health
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Inflammasome and immune disorders
- Metal complexes synthesis and properties
- RNA Interference and Gene Delivery
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
Cincinnati Children's Hospital Medical Center
2025
Purdue University West Lafayette
2017-2023
Persistent infection with HPV causes nearly 5% of all cancers worldwide, including cervical and oropharyngeal cancers. Compared to HPV-negative (HPV−) head neck squamous cell carcinomas (HNSCCs), HPV-positive (HPV+) HNSCCs exhibit a significantly improved treatment response; however, established regimens were largely developed for HPV− disease. Effectively de-escalating therapy optimizing protocols minimize toxicity both HPV+ tumors has been variably successful, in part due the heterogeneity...
Mesenchymal stromal cells (MSCs) are a multipotent cell population of clinical interest because their ability to migrate injury and tumor sites, where they may participate in tissue repair modulation immune response. Although the processes regulating MSC function incompletely understood, it has been shown that stimulation Toll-like receptors (TLRs) can alter activity. More specifically, reported human bone marrow-derived MSCs be "polarized" by TLR priming into contrasting immunomodulatory...
Some cytokines can reengineer anti-tumor immunity to modify the tumor micro-environment. Interleukin-27 (IL-27) partially reduce growth in several animal models, including prostate cancer. We hypothesized that addition of IL-18, which induce proliferation immune effector cells through inducing IFNγ could synergize with IL-27 enhance control. describe our findings on effects gene delivery cancer and how sequential therapy IL-18 enhanced efficacy IL-27. The combination followed by (27→18)...
An emerging approach in treating skeletal malignancies utilizes osteoimmunology to investigate new multifunctional immune-stimulatory agents that can simultaneously combat tumor growth and promote bone repair. We have hypothesized cytokine Interleukin-27 (IL-27) is an excellent candidate biologic help rebalance the prostate cells cell environment. In this work, we examined proof of principle for a short, secreted luciferase (Nanoluc or Nluc) fusion with IL-27 produce novel cytokine-based...
Introduction: Mesenchymal stromal cells (MSC) are envisioned as a potential cellular vehicle for targeted cancer therapies due to their tumor tropism and immune permissiveness. An obstacle in use is the duality interactions within tumors, rendering them pro-tumorigenic or anti-tumorigenic, context dependent manner. MSC preconditioning, priming, has been proposed strategy directing effector properties of at sites. Methods: We primed human derived from adipose tissues (ASC), clinically...
Mesenchymal stem/stromal cells (MSCs) are a multipotent stromal cell population of interest for clinical applications in different diseases due to their ability home injury, differentiate into non‐hematopoietic lineages, and secrete paracrine factors with roles tissue repair immunomodulation. Although the manner which MSCs modulate many functions incompletely understood, it has been shown that modulating toll‐like receptor (TLR) signaling can alter MSC activity. Promoting desired effector...
Mesenchymal stem cells (MSCs) have been studied often to assess their potential use in cell therapy because of capacity differentiate into non‐hematopoietic lineages, modulate immune responses, and promote tissue repair regeneration. In addition, MSCs found roles the promotion or repression tumor growth migration. However, mechanisms by which MSC affect are not fully understood. Studies with bone marrow‐derived shown that these can be polarized Toll‐like receptor (TLR) signaling two...
Abstract Mesenchymal stem cells (MSCs) are a potential tool for cell therapy because of their ability to home injury sites, modulate immune responses, promote tissue repair, among other features. MSCs can also tumors, similarly how they and exert modulatory functions in the tumor microenvironment. However, mechanisms by which affect is not well understood, apparent contradictory effects MSC-tumor interactions be found literature, claiming that either or repress growth migration. In recent...
Mesenchymal stem/stromal cells (MSCs) are a multipotent stromal cell population of interest for their potential use in therapy and immunotherapy due to many interesting traits, such as: ability home injury sites, differentiate into non‐hematopoietic lineages, secretion paracrine factors with roles tissue repair immunomodulation. Similarly how they MSCs can also tumors, there exert modulatory functions the tumor microenvironment. Contrasting MSC effects on progression have been reported...