A5002642804- Heart Rate Variability and Autonomic Control
- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Neural and Behavioral Psychology Studies
- Retinal Development and Disorders
- Zebrafish Biomedical Research Applications
- Neural dynamics and brain function
- Hearing Loss and Rehabilitation
- Cellular transport and secretion
- Functional Brain Connectivity Studies
- Neurobiology and Insect Physiology Research
- Genetics and Neurodevelopmental Disorders
- Endoplasmic Reticulum Stress and Disease
University of Southern California
2021-2025
Scripps Research Institute
2022-2024
Oklahoma State University
2023
Protein degradation is critical for brain function through processes that remain incompletely understood. Here, we investigated the in vivo of 20S neuronal membrane proteasome (NMP) Xenopus laevis tadpoles. With biochemistry, immunohistochemistry, and electron microscopy, demonstrated NMPs are conserved tadpole preferentially degrade activity–induced newly synthesized proteins vivo. Using calcium imaging optic tectum, showed acute NMP inhibition rapidly increased spontaneous activity,...
Abstract Introduction: Effective prevention and management strategies for chronic pain remain elusive. This has prompted investigations into biomarkers to better understand the mechanisms underlying development persistence. One promising marker is low peak alpha frequency (PAF), an electroencephalography (EEG) measure that been associated with increased sensitivity during acute experimental pain. However, findings regarding relationship between PAF are variable, potentially due disparate...
Abstract Background Low peak alpha frequency (PAF) is an electroencephalography (EEG) outcome associated reliably with high acute pain sensitivity. However, existing research suggests that the relationship between PAF and chronic more variable. This variability could be attributable to groups typically being examined as homogenous populations, without consideration given potential diagnosis‐specific differences. Indeed, while emerging work has compared individuals healthy controls, no...
tadpoles exhibit an avoidance behavior when they encounter a moving visual stimulus. A event occurs object approaches the eye of free-swimming animal at approximately 90-degree angle and turns in response to encounter. Analysis this requires tracking both stimulus prior after Previous automated software does not discriminate from stimulus, requiring time-consuming manual analysis. Here we present X-Tracker, code that can detect stimuli animals score encounters events. X-Tracker is as...
ABSTRACT Protein degradation is critical for brain function through processes that remain poorly understood. Here we investigated the in vivo of a recently reported neuronal membrane-associated proteasome (NMP) Xenopus laevis tadpoles. We demonstrated NMPs are present tadpole with biochemistry and electron microscopy, showed they actively degrade activity-induced nascent proteins. Using calcium imaging optic tectum, acute inhibition NMP rapidly increased spontaneous activity, resulting...
Introduction: The purpose of the current study was to evaluate speech intelligibility and rate in individuals with Parkinson’s disease using altered auditory feedback (AAF) comparison age-matched healthy controls. Based on prior research, it is hypothesized that use AAF will improve participants’ intelligibility. Methods: Five (clinical group) five controls aged 50 years above participated this pre-/post-group experiment. All participants completed reading monologue tasks without AAF....