A5065494498- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Pharmaceutical and Antibiotic Environmental Impacts
- Glycosylation and Glycoproteins Research
- Environmental Toxicology and Ecotoxicology
- Advanced Proteomics Techniques and Applications
- Magnetic Properties and Synthesis of Ferrites
- Advanced Chemical Physics Studies
- Chemical Reactions and Isotopes
- Sleep and related disorders
- Chemical Synthesis and Analysis
- Physics of Superconductivity and Magnetism
- Lipid Membrane Structure and Behavior
- Sensor Technology and Measurement Systems
- Sphingolipid Metabolism and Signaling
- Ion-surface interactions and analysis
- Salivary Gland Disorders and Functions
- Effects and risks of endocrine disrupting chemicals
- Isotope Analysis in Ecology
- Water Treatment and Disinfection
- Analytical chemistry methods development
- Iron-based superconductors research
- ATP Synthase and ATPases Research
- Protein Structure and Dynamics
- Circadian rhythm and melatonin
Rudjer Boskovic Institute
2015-2024
Catalan Institute for Water Research
2017-2023
University of Connecticut
2022-2023
Universidad Autónoma de Madrid
2005
Jožef Stefan Institute
1992-1998
University of Ljubljana
1992-1994
A wide range of pharmaceuticals and endocrine disrupting compounds enter freshwaters globally. As these contaminants are transported through aquatic food webs, understanding their impacts on both terrestrial ecosystems remains a major challenge. Here, we provide the first direct evidence transfer disruptors aquatic–terrestrial habitat linkage by emerging insects. We also show that type insect metamorphosis feeding behavior determine bioaccumulation patterns contaminants. Adult Trichoptera,...
Hydrothermal synthesis has been used to synthesize nano‐sized manganese zinc ferrite powder. The results show that the pH value of starting suspension a decisive influence on composition hydrothermally prepared At ∼8.5, stoichiometric amounts and can be incorporated in ferrite. grain size powder increases with temperature time hydrothermal treatment. nanosized produced is superparamagnetic becomes ferri‐magnetic after grains become larger than ∼100 nm. are very prone oxidation disintegrate...
The dissolved organic matter (DOM) in wastewater is typically described by a limited number of concentration measurements select DOM fractions or micro-contaminants, which determine the removal efficiency treatment. Current methods do not necessarily reflect true performance treatment with regard to environmental and public health risk. Herein we describe development application non-targeted liquid chromatography-high resolution mass spectrometry (LC-HRMS) data analysis for evaluation...
In this paper, nanostructured TiO₂ film was prepared by the sol-gel process and dip-coating technique with titanium tetraisopropoxide as a precursor. After heat treatment at 550 °C, deposited characterized means of micro-Raman spectroscopy atomic force microscopy (AFM). It found that consisted only anatase phase showed granular microstructure. Photocatalytic degradation azithromycin using studied to define most effective for potential use in wastewater treatment. Different factors were...
The sintering and microstructural evolution of nanosized MnZn ferrite powders prepared by a hydrothermal method were investigated. microstructure sintered compacts depends strongly on the strength agglomerates formed during compacting powders. It was found that at 700°C theoretical density can almost be reached, while above 900°C an increase porosity identified. formation extra higher temperatures is caused mainly oxygen release which accompanies dissolution relatively large grains residual...
Gas-phase H/D exchange and density functional theory study of the Asp Glu side-chain carboxylic group intrinsic reactivity is reported. site specific treatment some additional theoretical calculations showed that a may initiate proton transfer along with bond formation to one its oxygens, i.e., possibility selective cleavage peptide ("aspartic acid effect"). That finding used select aspartic mechanisms (side-chain either backbone carbonyl or amide nitrogen) for further computational study....
The gas-phase dissociation of phosphorylated peptides was modelled using a combination quantum mechanics and the Rice–Ramsperger–Kassel–Marcus theory. Potential energy surfaces unimolecular reaction rates for several low-energy fragmentation rearrangement pathways were estimated, general mechanism proposed. neutral loss phosphoric acid mainly an outcome intramolecular nucleophilic substitution mechanism. involves attack amino N-terminal carbonyl oxygen on β-carbon, yielding cyclic...
ABSTRACT In the present study, we investigated possible combined anticancer ability of bee venom (BV) and cisplatin towards two pairs tumour cell lines: parental cervical carcinoma HeLa cells their cisplatin‐resistant CK subline, as well laryngeal HEp‐2 CK2 subline. Additionally, identified several peptides BV in sample used course study determined exact concentration MEL. applied alone concentrations 30 to 60 µg ml –1 displayed dose‐dependent cytotoxicity against all lines tested....
The recent identification of plasma membrane (Ca2+)-ATPase (PMCA)-Neuroplastin (Np) complexes has renewed attention on cell regulation cytosolic calcium extrusion, which is particular relevance in neurons. Here, we tested the hypothesis that PMCA-Neuroplastin exist specific ganglioside-containing rafts, could affect homeostasis. We analyzed abundance all four PMCA paralogs (PMCA1-4) and Neuroplastin isoforms (Np65 Np55) lipid rafts bulk fractions from GM2/GD2 synthase-deficient mouse brains....
The dissociation of protein ions (5–30 kDa) as a function charge state has been explored in order to suggest the optimal range for top‐down sequencing. Proteins were generated under denaturing conditions and their states modified via ion/ion proton transfer reactions prior dissociation. Electron (ETD) data suggested sequence coverage m/z from 700 950 while limited was noted when precursor above 1000. Sequence ETD found be dependent on size, with smaller proteins having better coverage. An...
Gas-phase H/D exchange experiments with CD3OD and D2O quantum chemical ab initio G3(MP2) calculations were carried out on protonated histidine methyl ester in order to elucidate their bonding structure. The show that both ions have three equivalent fast hydrogens one appreciably slower exchangeable hydrogen assigned the amino group participating a strong intramolecular bond (IHB) nearest N(sp2) nitrogen of imidazole fragment distal ring NH-group, respectively. It is taken for granted proton...
Abstract The complexes formed by alkali metal cations (Cat + = Li , Na K Rb ) and singly charged tryptic peptides were investigated combining results from the low‐energy collision‐induced dissociation (CID) ion mobility experiments with molecular dynamics density functional theory calculations. structure reactivity of [M H Cat] 2+ is greatly influenced charge repulsion as well ability peptide to solvate points. Charge separation between fragment ions occurs upon dissociation, i.e. b tend be...
Melatonin's role in circadian rhythm is well documented, as are its' anti-oxidant, oncostatic and anti-inflammatory properties. Poor sleep quality has been associated a potential risk factor for several malignancies, including head neck cancers. The purpose of this study to determine salivary melatonin (MLT) levels oral squamous cell carcinoma (OSCC) patients, compare the MLT with those healthy individuals serum OSCC patients. Furthermore, aim investigate relationship between Unstimulated...
The gas-phase interaction of sodiated amino acids and acid methyl esters with various deuterium donors is investigated by combining results H/D exchange reactions those from density functional theory molecular dynamics calculations. Discrepancy between experimentally theoretically obtained structures for sodium cationized explained donor caused perturbation the most stable conformation. Detailed study mechanism on shows that reaction preceded a multistep quasi-isoenergetic transition...