A5078054289- Neuroscience and Neuropharmacology Research
- Lipid Membrane Structure and Behavior
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Hearing, Cochlea, Tinnitus, Genetics
- Functional Brain Connectivity Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetics and Neurodevelopmental Disorders
- Cellular transport and secretion
- Testicular diseases and treatments
- Connexins and lens biology
- Neurogenesis and neuroplasticity mechanisms
- Vestibular and auditory disorders
- Tryptophan and brain disorders
- Ear Surgery and Otitis Media
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Glycosylation and Glycoproteins Research
- Ion channel regulation and function
- Biochemical Analysis and Sensing Techniques
- Sperm and Testicular Function
- Monoclonal and Polyclonal Antibodies Research
Leibniz Institute for Neurobiology
2019-2024
Ketamine is a common anaesthetic agent used in research and more recently as medication treatment of depression. It has known effects on inhibition interneurons cortical stimulus-locked responses, but the underlying functional network mechanisms are still elusive. Analysing population activity across all layers within auditory cortex, we found that doses this induce stronger activation response to pure-tone stimuli. This driven by gain enhancement thalamocortical input processing selectively...
Abstract Autism spectrum disorder (ASD) is a heterogeneous neurodevelopment resulting from different etiological factors, both genetic and/or environmental. These factors can lead to abnormal neuronal development on dendrite and synaptic function at the central nervous system. Recent studies have shown that subset of ASD patients display increased circulation levels tyrosine metabolite, p ‐cresol, related chronic intestinal disorders because dysbiosis microbiota. In particular, presence...
The recent identification of plasma membrane (Ca2+)-ATPase (PMCA)-Neuroplastin (Np) complexes has renewed attention on cell regulation cytosolic calcium extrusion, which is particular relevance in neurons. Here, we tested the hypothesis that PMCA-Neuroplastin exist specific ganglioside-containing rafts, could affect homeostasis. We analyzed abundance all four PMCA paralogs (PMCA1-4) and Neuroplastin isoforms (Np65 Np55) lipid rafts bulk fractions from GM2/GD2 synthase-deficient mouse brains....
Upon postsynaptic glutamate receptor activation, the cytosolic Ca2+ concentration rises and initiates signaling plasticity in spines. The plasma membrane ATPase (PMCA) is a major player to limit duration of signals. It forms complexes with glycoprotein neuroplastin (Np) isoforms Np55 Np65 functionally interplays N-methyl-D-aspartate (NMDA)-type ionotropic receptors (iGluNRs). Moreover, binding Np65-specific extracellular domain Ca2+-permeable GluA1-containing...
Hearing deficits impact on the communication with external world and severely compromise perception of surrounding. Deafness can be caused by particular mutations in neuroplastin (Nptn) gene, which encodes a transmembrane recognition molecule immunoglobulin (Ig) superfamily plasma membrane Calcium ATPase (PMCA) accessory subunit. This study investigates whether complete absence or loss adult after normal development lead to hearing impairment mice analyzed behavioral, electrophysiological,...
Male reproduction depends on hormonally driven behaviors and numerous genes for testis development spermatogenesis. Neuroplastin-deficient (Nptn−/−) male mice cannot sire offspring. By immunohistochemistry, we characterized neuroplastin expression in the testis. Breeding, mating behavior, hormonal regulation, testicular development, spermatogenesis were analyzed cell-type specific mutant mice. Leydig, Sertoli, peritubular myoid, germ cells express Np, but sperm number are not affected...
The N-methyl-D-aspartate (NMDA) receptor antagonist, ketamine, is commonly used as an anesthetic agent and has more recently gained attention antidepressant. Ketamine been linked to increased stimulus-locked excitability, inhibition of interneurons, modulation intrinsic neuronal oscillations. However, the functional network mechanisms are still elusive. A better understanding these effects may improve upon previous interpretations seminal studies conducted under anesthesia have widespread...