A5090250729- Sulfur-Based Synthesis Techniques
- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- X-ray Diffraction in Crystallography
- Synthesis and biological activity
- Inflammatory mediators and NSAID effects
- Synthesis and Biological Evaluation
- Quinazolinone synthesis and applications
- Synthesis and Reactions of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Catalytic Cross-Coupling Reactions
- Membrane Separation Technologies
- Synthesis of heterocyclic compounds
- Nanomaterials for catalytic reactions
- Synthesis of Indole Derivatives
- Cyclopropane Reaction Mechanisms
- Electrohydrodynamics and Fluid Dynamics
- Crystallography and molecular interactions
- Coagulation and Flocculation Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Synthesis of β-Lactam Compounds
- Multicomponent Synthesis of Heterocycles
- Click Chemistry and Applications
National Institute of Technology Kurukshetra
2013-2022
Shri Vishwakarma Skill University
2022
Indian Institute of Technology Delhi
2016-2018
Kurukshetra University
2011-2013
Copper chalcogenide nanoparticles (Cu2S) synthesized for the first time from a single-source precursor, CuSPh, act as highly efficient and reusable heterogeneous catalyst regioselective amination of N,N-dimethylbenzylamines with various azoles. The reaction involves N–H/C–H cross-dehydrogenative coupling (CDC) demonstrates wide functional group tolerance. It provides selective access to N1-alkylated benzotriazoles, N2-alkylated 1,2,3-triazoles 4-phenyl-1,2,3-triazoles, N-alkylated carbazoles...
A solvent-free green synthesis of N-sulfonylformamidines is reported via the direct condensation N,N-dimethylformamide dimethyl acetal (DMF-DMA) and sulfonamide derivatives at room temperature. The described method avoids use metal catalysts as well hazardous solvents, which are not permitted for pharmaceutical manufacture, reactions or isolation products. Hence, current work presents a fast efficient alternative to earlier methods. mild nature procedure demonstrated by varied functional...
Copper chalcogenide nanoparticles (Cu7S4) supported on graphene oxide (GO) have been synthesized for the first time from Cu2S, and used as highly efficient heterogeneous catalysts oxidative ortho-selective C-H aminomethylation of phenols with N,N-dimethylbenzylamines. The NPs (30-80 nm) characterized by HRTEM, SEM-EDX, PXRD, FTIR, Raman, ICP-AES XPS analyses. NP catalyzed sp2-sp3 cross dehydrogenative coupling (CDC) features a broad substrate scope, excellent functional group tolerance, high...
An efficient copper-catalyzed intermolecular hydroindolation reaction of terminal aryl alkynes to expeditiously synthesize bis(indolyl)alkanes in moderate high yields is described. The double nucleophilic addition two molecules indole one molecule alkyne occurs a tandem manner through an anti-Markovnikov pathway. Various arenes and allow for this transformation. Preliminary mechanistic study sheds light on the observed regioselectivity involving Cu-vinylidene complex, 3-styryl-1H-indole as...
A series of pyrazolylbenzyltriazoles as celecoxib analogues having a 1,5-diaryl relationship potential leads for the development molecular probes imaging COX-2 expression was prepared by reaction appropriate trifluoromethyl-β-diketones (12a–12i) with 1-[(4-hydrazinophen-1-yl)methyl]-1H-1,2,4-triazole hydrochloride in refluxing ethanol. All compounds were screened vitro cyclooxygenase (COX) assays to determine COX-1 and inhibitory potency. Moreover, anti-inflammatory activity selected...
An efficient and facile method to synthesize N-Mannich bases has been developed using an inexpensive copper(I) bromide/air catalyst system at ambient temperature. A cross-dehydrogenative coupling of N,N-dimethylarylamines occurs efficiently with aromatic heterocyclic amides (oxindoles, isatins), cyclic (lactams), simple (benzamide), as well imides (succinimide, phthalimide) furnish the corresponding amidated/imidated derivatives in good excellent yields. Preliminary mechanistic...
A quick and efficient method for the reduction of azides to amines in water using <sc>d</sc>-glucose KOH as green reagents is reported.
A simple and efficient iodine-assisted protocol for synthesis of 5-substituted-3-methyl/benzyl-1,3,4-oxadiazol-2(3<italic>H</italic>)-ones has been developed.
A series of novel derivatives 1,3-oxazolidin-2-one 12a-12n has been synthesized starting from 4-nitro-(L)- phenylalanine by involving five-step reaction sequence. All the compounds were screened for their in vitro antibacterial activity against four pathogenic bacterial strains namely, Staphylococcus aureus, Bacillus subtilis (Gram-positive), Escherichia coli, Pseudomonas aeruginosa (Gram-negative) and antifungal two fungal Candida albicans Saccharomyces cerevisiae. showed Gram-positive...
Abstract from readily available carbazates and aldehydes under transition‐metal‐free conditions