About
Contact & Profiles
A5102817994
Research Areas
- Pancreatic function and diabetes
- CRISPR and Genetic Engineering
- Sirtuins and Resveratrol in Medicine
Jeonbuk National University
2019
Nicotinamide is used to maturate pancreatic progenitors from embryonic stem cells (ESCs) into insulin-producing (IPCs). It has been known that nicotinamide inhibits the enzymatic activity of SIRT1, an NAD+-dependent deacetylase. Here we show SIRT1 knockdown enhances differentiation human ESCs IPCs. clustering size IPCs and expression genes including c-peptide, pancreas/duodenum homeobox protein 1 (PDX1), insulin, somatostatin, glucagon Nkx6.1 in ESC-derived In addition, We found...
10.12717/dr.2019.23.4.391
article
EN
Development & Reproduction
2019-12-01
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