A5062138581- Fashion and Cultural Textiles
- Advanced NMR Techniques and Applications
- Prion Diseases and Protein Misfolding
- Crafts, Textile, and Design
- Alzheimer's disease research and treatments
- Cultural Industries and Urban Development
- Visual Culture and Art Theory
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Innovative Microfluidic and Catalytic Techniques Innovation
- Solid-state spectroscopy and crystallography
- Pharmacogenetics and Drug Metabolism
- Total Knee Arthroplasty Outcomes
- Medical Practices and Rehabilitation
- Quantum Dots Synthesis And Properties
- Trace Elements in Health
- Graphic Design and Typography
- Zeolite Catalysis and Synthesis
- Metabolomics and Mass Spectrometry Studies
- Art, Politics, and Modernism
- Infectious Encephalopathies and Encephalitis
- Clinical practice guidelines implementation
- Chalcogenide Semiconductor Thin Films
- Poxvirus research and outbreaks
- Glass properties and applications
TU Bergakademie Freiberg
2021
Heinrich Heine University Düsseldorf
2006-2021
Forschungszentrum Jülich
2018-2021
TU Dortmund University
2010-2014
University of the Arts London
2013
University of Duisburg-Essen
2009
Alb Fils Kliniken
2004
Aims: The introduction of clearly defined histopathological criteria for a standardised evaluation the periprosthetic membrane, which can appear in cases total joint arthroplasty revision surgery. Methods: Based on histomorphological criteria, four types membrane were defined: wear particle induced type (detection foreign body particles; macrophages and multinucleated giant cells occupy at least 20% area; I); infectious (granulation tissue with neutrophilic granulocytes, plasma few, if any,...
Human PrP (huPrP) is a high-affinity receptor for oligomeric amyloid β (Aβ) protein aggregates. Binding of Aβ oligomers to membrane-anchored huPrP has been suggested trigger neurotoxic cell signaling in Alzheimer's disease, while an N-terminal soluble fragment can sequester and reduce their toxicity. Synthetic species are known be heterogeneous, dynamic, transient, rendering structural investigation particularly challenging. Here, using preserve by coprecipitating them into large...
Over the course of twentieth century, availability cheap, mass-produced fashion has contributed to a decline in everyday domestic mending skills. Indeed, as mass-manufactured goods have become cheaper for global population it normative consumer behaviour dispose any item that is less than perfect, even when damage entirely superficial, leading Clark claim that: ‘mending died out’ (2008: 435).
 However, recent years there been an apparent revival mending, aided and evidenced by emergence...
The resolution of the three-dimensional structure infectious prions at atomic level is pivotal to understand pathobiology Transmissible Spongiform Encephalopathies (TSE), but has been long hindered due certain particularities these proteinaceous pathogens. Difficulties related their purification from brain homogenates disease-affected animals were resolved almost a decade ago by development in vitro recombinant prion propagation systems giving rise highly prions. However, lack knowledge...
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of people worldwide. One AD hallmark the aggregation β-amyloid (Aβ) into soluble oligomers and insoluble fibrils. Several studies have reported rather than fibrils are most toxic species in progression. Aβ bind with high affinity to membrane-associated prion protein (PrP), leading signaling across cell membrane, which makes Aβ–PrP interaction an attractive therapeutic target. Here, probing this more...
Colloidal CdS nanoparticles are conjugated with a variety of proteins, including enhanced yellow fluorescent protein, tobacco etch virus protease (TEV), lysozyme, and bacterial cytochrome P450 CYP152A1, the photochemical properties resulting conjugates analyzed by EPR spectroscopy hydroxyl radical-specific fluorimetric assay. While irradiation bare colloids leads to photogeneration superoxide radicals, it is surprisingly observed that coating particles proteins effectively suppresses...
We present a microfluidic device for coupled phase I/phase II metabolic reactions in vitro. The chip consists of microchannels, which are used as packed bed reactor compartments, filled with superparamagnetic microparticles bearing recombinant microsomal I cytochrome P450 or conjugating enzymes (UDP-glucuronosyltransferase). Online coupling the LC/MS enabled quantitative assessment transformations, demonstrated two different substrates, 7-benzyloxy-4-trifluoromethylcoumarin (BFC) and...
Konig aims to identify the most distinctive or enduring elements of fashion text appearing in Vogue between 1980 and 2001; analyse closely content, tone, lexicon, cultural references order patterns continuity change. Once these parameters have been established, author argues that it becomes possible contextualise findings within a framework existing work this area, discuss broader issues pertaining language textual constructions world. The article concludes written is less rigid predictable...
Fluorescence resonance energy transfer (FRET) combined with confocal laser microscopy is a powerful tool to analyze protein−protein interaction in vivo . We have applied this combination study the assembly of hypoxia‐inducible factor (HIF) complex living cells under hypoxic conditions. In hypoxia, basic helix‐loop‐helix/Period/ARNT/Single‐minded (PAS) proteins HIF‐1α and HIF‐2α accumulate are translocated into nucleus. Here, dimerize HIF‐1β, also known as aryl hydrocarbon receptor nuclear...
BACKGROUND AND RESEARCH GOAL: All German hospitals have to participate by law in comparative performance assessment, so called external quality assurance (QA). However, there is only limited research showing a positive impact of such state- and nationwide QA programmes. This article analyses whether the surgical gynaecological care Hessian changed after receiving regular feedback on between 1998 2002.Secondary data analysis from all with services Hesse (n = 84) was performed. The requirement...
ABSTRACT Human PrP (huPrP) is a high-affinity receptor for oligomeric Aβ. Synthetic Aβ species are known to be heterogeneous, dynamic and transient, rendering their structural investigation particularly challenging. Here, we used huPrP preserve oligomers by co-precipitating them into large hetero-assemblies investigate the conformation of Aβ(1-42) in complex solid-state MAS NMR spectroscopy. The disordered N-terminal region becomes immobilized therefore visible dipolar spectra without...