It was proposed that resveratrol, a polyphenolic antioxidant and calorie restriction mimetic could promote longevity but subsequent studies not prove this. The original proposal based on the fact grape-derived activate antiaging gene Sirt1. Most agree indeed grape activates Sirt1, question remains whether Sirt1 is cause or consequence of resveratrol treatment. Subsequently, mitochondrial Sirt3 found to be activated. present study ischemic reperfusion (I/R) in rat hearts demonstrates Foxo3a...

This study tested the hypothesis that induction of autophagy by producing therapeutic amounts endoplasmic reticulum (ER) stress in heart before an ischemic insult would ameliorate/reduce subsequent lethal myocardial ischemic/reperfusion (I/R) injury (similar to preconditioning). A dose-response with both tunicamycin and thapsigargin was performed determine optimal dose (0.3 mg/kg) for inducing cardioprotection. The Sprague-Dawley rats weighing between 250 300 g were randomly assigned into...

<b>Objectives:</b> The study was conducted to assess knowledge, attitude, and practice regarding insulin use among diabetic patients in tertiary care hospitals. <br> <b>Materials Methods:</b> Type 1 2 patients, aged 18 years above, attending the Medicine/Endocrinology out-patient department or admitted as in-patients three hospitals around Kolkata were enrolled. A pretested structured questionnaire comprising of 51 items administered through face-to-face interview. Responses from 385...

Lipid rafts represent a sub-compartment of the plasma membrane that co-ordinate and regulate varieties signalling processes, whereas caveolins are integral protein lipid raft. Recent evidence demonstrated pivotal role in cardioprotection against ischaemic injury, although their mechanism action is not clear. However, new understanding epigenetic modification during ischaemia reperfusion suggests additional targeted approaches have been explored before. To study caveolin on regulation,...

Resveratrol, a constituent of red wine, and γ-tocotrienol, palm oil are important for cardioprotection. Although microRNAs known regulators genes involved in cardiac remodelling, the regulatory pathway involving microRNA has not been studied so far. We explored cardioprotection by resveratrol, longevinex γ-tocotrienol ischaemia/reperfusion(I/R) model rat determined miRNA profile from isolated RNA. Systemic analyses array theirs targets were using number computational approaches. Resveratrol...

Citicoline is a novel neuroprotective agent used in acute stroke with significantly favorable outcome.A hundred patients who suffered from either an ischemic and hemorrhagic presented to the hospital within 48 h of onset were enrolled for study. Of these 100 (age- sex-matched), 50 treated citicoline along standard management considered as 'cases'. The other administered treatment 'controls.' baseline parameters was assessed using National Institute Health Stroke Scale. reassessed at follow...

Diabetes mellitus is the most common endocrinological disease associated with different life-threatening infections. Urinary Tract Infection one of them which may lead to Intensive care Unit admission and even death. In this study, we would like find out spectrum uropathogen its antibiotic sensitivity, so that can choose empirical antibiotics early save lives.To uropathogens in Diabetic patients attending Clinic a tertiary hospital Antibiotic sensitivity pattern isolated bacteria.In...

Coenzyme Q10 (CoQ10) has been extensively studied as adjunctive therapy for ischemic heart disease, and its cardioprotective ability is well-established. The mitochondrial respiratory chain contains several coenzymes, including CoQ1, CoQ2, CoQ4, CoQ6, CoQ7, CoQ8, CoQ9, CoQ10. It not known whether other CoQs, especially equally present study was designed to determine if CoQ9 could protect guinea pig hearts from ischemia reperfusion injury. Guinea pigs were randomly divided into three groups:...

Malaria is known for its protean manifestations and multi systemic complications. Acute pancreatitis as a consequence of falciparum malaria rare in the literature. We report case complicated by acute pancreatitis.

Chronic arsenicosis is a major health and occupational problem in rural parts of West Bengal such as the Gangetic plain India. occurs due to accidental ingestion repeated amounts small doses by those working with metal or taking food drink which there are traces arsenic. exposure may result accumulation hair, nail, skin. Arsenic can also cross placenta. Papillon-Lefθvre syndrome rare disease characterized skin lesions caused palmar-plantar hyperkeratosis severe periodontal destruction...

Recurrent pyogenic liver abscess since childhood is an uncommon finding in clinical medicine. Papillon-Lefèvre syndrome (PLS) a rare disease characterized by skin lesions caused palmar-plantar hyperkeratosis, and severe periodontal destruction involving both the primary permanent dentitions. Till date, more than 200 cases have been reported worldwide. In addition to oral findings, patients may immune suppression increased susceptibility bacteria, associated with recurrent infections of skin....

Malaria poses a major public health problem in India, where it is endemic, especially severe malaria caused by Plasmodium falciparum infestation. There have been great changes the clinical manifestation of over past couple decades, with shift from cerebral to fever jaundice, renal failure, bleeding diathesis, and multi-organ dysfunction syndrome. Here, we discuss two cases which presented extremely uncommon neurological manifestations.

Introduction: Psoriasis is a chronic, inflammatory, immune-mediated skin disease affecting approximately 2-3% of the global population. Besides traditional co-morbidities associated with psoriasis, an emerging co-morbidity metabolic syndrome. and syndrome are likely linked together due to underlying chronic inflammatory nature in large part, increased tumor necrosis factor-alpha. Aim: To study association between psoriasis its components. Materials Methods: A case-control, hospital-based...

Systemic lupus erythematosus is an autoimmune systemic disease, particularly affecting women of reproductive age group. Male and associated nephropathy very uncommon. Elderly male presenting with still a rare finding in literature. We report case 67-year-old heavy proteinuria. also conclude that sex patient no bar for lupus, every physician must consider disease even elderly patients.

A hepatobronchial fistula is an anatomic communication between the liver parenchyma and bronchial tree. Major causes of such fistulae include inflammatory conditions resulting from obstruction biliary tract infectious processes, as pyogenic abscesses, amebiasis, hydatid cysts. We report a rare case patient (with chronic, recurrent hepatic abscess), who suffered persistent, productive cough with green colored sputum fistula.

Spontaneous rectus sheath hematoma occurs commonly in patients with coagulation disorder or as a complication of anticoagulant therapy. Glanzmann's thrombasthenia (GT) usually presents mucocutaneous bleed, menorrhagia, hematoma/hemarthrosis and, rarely, visceral hematoma. We report case spontaneous an emergency patient GT, very rare presentation. In this case, 14-year-old girl presented acute pain abdomen and palpable mass at the left lower abdomen. She was investigated found to have which

Pheochromocytomas are relatively uncommon tumors, with prevalence of 0.3-0.95% in autopsy series. Patients pheochromocytomas have a potentially curable cause hypertension. Following surgical removal pheochromocytoma 80% patients expected to become normotensive. Persistent post-operative hypertension may be due residual tumor, metastatic disease or intra-operative injury the renal artery kidney. Around 20% will remain hypertensive without biochemical evidence tumor; however, associated...