Integrating self-healing capability into supramolecular architectures is an interesting strategy, and can considerably enhance the performance broaden scope of applications for this important class polymers. Herein we report rational design novel V-shaped barbiturate (Ba) functionalized soft-hard-soft triblock copolymers with a reversible healing motif in central part hard block, which undergoes autonomic repair at 30 °C. The designed synthesis also offers suitable macromolecular building...

Hydrogen bonds (H-bonds) constitute highly relevant structural units of molecular self-assembly. They bridge biological and synthetic sciences, implementing dynamic properties into materials molecules, not achieved via purely covalent bonds. Phase segregation on the other hand represents another important assembly principle, responsible for, e.g., cell compartimentation, membrane-formation, microphase in polymers. Yet, despite expanding elegant strategies supramolecular polymers,...

Abstract High‐performance adhesives are of great interest in view industrial demand. We herein identify a straightforward synthetic strategy towards universal hydrogen‐bonded (H‐bonded) polymeric adhesives, using side‐chain barbiturate (Ba) and Hamilton wedge (HW) functionalized copolymer. Starting from rubbery copolymer containing thiolactone derivatives, Ba HW moieties tethered as pendant groups via an efficient one‐pot two‐step amine‐thiol‐bromo conjugation. Hetero‐complementary Ba/HW...

Adhesive bonding to diverse substances is vital a great number of the established, cutting-edge and emerging applications. We have witnessed, in last few years, transformative progress achieving robust adhesive tunable debonding behavior, which mostly employing supramolecular forces. Among forces, contribution hydrogen-bonds (H-bonds) adhesives, on modality directionality, selectivity sensitivity, can function as nano-scaled agents for improved interfacial interactions, thus paved novel...

The outcomes of combined cancer therapy are largely related to loading content and contribution each therapeutic agent; however, fine-tuning the ratio two coloaded components toward precise is a great challenge still remains in its infancy. We herein develop supramolecular polymer scaffold optimize coloading chemotherapeutic agent photosensitizer through hydrogen-bonding (H-bonding) interaction, for maximizing efficacy intelligent chemo/photodynamic therapies (CT/PDT). To do so, we first...

Abstract The structural rigidity of thiourea (TU) motifs has made them useful in supramolecular (bio)materials. However, the role TU motif a single system endowing dual noncovalent interactions, i.e., Hydrogen‐bonding (H‐bonding) association and metal‐coordination interaction, to afford nanomedicine is still unexplored. Herein smart polymeric constructed via privileged toward synergistic chemo/chemodynamic (CT/CDT) cancer therapy reported. study first synthesized six‐arm star‐shaped...

Photonic crystals (PCs) are ideal candidates for reflective color pigments with high purity and brightness due to tunable optical stop band. Herein, the generation of PC microspheres through 3D confined supramolecular assembly block copolymers (polystyrene-block-poly(2-vinylpyridine), PS-b-P2VP) small molecules (3-n-pentadecylphenol, PDP) in emulsion droplets is demonstrated. The intrinsic structural colors effectively regulated by tuning hydrogen-bonding interaction between P2VP blocks PDP,...

Abstract Precise cancer nanomedicine requires rational molecular instructions of therapeutic agents. Harnessing the structure‐property‐function relationships represents a practical strategy toward smart and effective nanomedicine. A structurally novel hydrogen‐bonded (H‐bonded) supramolecular nanoformulation generated by orthogonal self‐sorting assembly chemo‐prodrug (FPtF) phototherapeutics (BPeB) is here reported, to reach an autonomous with improved anti‐tumor efficacy combining...

Supramolecular miktoarm stars (AB2 type) composed of poly (methyl methacrylate)-polystyrene2 (PMMA-PS2), poly(isoprene)-polystyrene2 (PI-PS2), and poly(vinyl acetate)-polystyrene2 (PVAc-PS2) were successfully synthesized by assembling reversible addition−fragmentation chain transfer (RAFT)-polymerized chains bearing hydrogen-bonding heterocomplementary associating units. To this end, thymine diaminopyridine-functionalized agents designed to efficiently mediate the polymerization vinyl...

We report an original strategy toward the straightforward preparation of precisely defined telechelic H-bonding polymers and generation supramolecular block copolymers thereof. Making use α,ω-functionalized symmetrical trithiocarbonate bearing thymine groups at both chain ends, a series heterocomplementary were effortlessly generated by RAFT polymerization in one step process. The resulting macromolecules selectively interacted with α-DAP-functionalized chains to afford solution bulk. These...

Tumor recurrence and metastasis are the main causes of cancer mortality; traditional chemotherapeutic drugs have severe toxicity side effects in treatment. To overcome these issues, here, we present a pH-responsive, self-destructive intelligent nanoplatform for magnetic resonance/fluorescence dual-mode image-guided mitochondrial membrane potential damage (MMPD)/photodynamic (PDT)/photothermal (PTT)/immunotherapy breast treatment with external near infrared (NIR) light irradiation. do so,...

The field of anticancer nanomedicine seeks to boost the arsenal's exploitation with intelligent performance. One opportunistic choice comes from fabrication amphiphilic polymer micelles that are reversibly crosslinked. Here, hydrogen-bond (H-bond)-driven core-crosslinked supramolecular (FUS/ICG@PEDD) constructed, co-loading α,ω-functionalized symmetrical H-bonding prodrug 5-fluorouracil-acetic acid–SS–5-fluorouracil-acetic acid (FUS) and a dual photothermal/photodynamic agent (indocyanine...

One of the major goals biomedical science is to pioneer advanced strategies toward precise and smart medicine. Hydrogen-bonding (H-bonding) assembly incorporated with an aggregation-induced emission (AIE) capability can serve as a powerful tool for developing supramolecular nanomedicine clear tumor imaging therapeutic performance. We here report H-bonded polymeric nanoformulation AIE characteristic antitumor therapy. To do so, we first design structurally novel tetraphenylethylene...

In this work, it is reported that large-area (centimeter-scale) arrays of non-close-packed polystyrene-tethered gold nanorod (AuNR@PS) can be prepared through a liquid-liquid interfacial assembly method. Most importantly, the orientation AuNRs in controlled by changing intensity and direction electric field applied solvent annealing process. The interparticle distance AuNR tuned varying length polymer ligands. Moreover, AuNR@PS with short PS ligand are favorited to form orientated assistance...

Heterotelechelic poly(n-butyl acrylate)s (PnBuA) bearing two different and complementing supramolecular groups (namely, barbiturate (Ba) the Hamilton wedge (HW)) at their α-end ω-end (Ba–PnBuA–HW) were prepared by a combination of reversible addition–fragmentation chain transfer (RAFT) process thio–bromo click reaction. The successful synthesis heterotelechelic H-bonding polymer Ba–PnBuA–HW (Mn,NMR = 7700 g/mol, Mn,SEC 7500 PDI 1.25) was proven 1H NMR MALDI-TOF mass spectrometry....

Complete cancer cure and healing are still difficult, owing to its complexity heterogeneity. Integration of supramolecular forces, for example, hydrogen bonds (H-bonds), anti-cancer nanomedicine affords new scaffolds biomedical material decoration, featuring the advantages dynamic property easier processability. Here, we target construction H-bond-mediated polymer micelles, loaded with a chemotherapeutic drug along photothermal agent synergistic chemo-/photothermal therapies (CT/PTT). To do...

Abstract Adhesive conducting elastomers are rising materials towards cutting‐edge applications in wearable and implantable soft electronics. Yet, engineering the conductive adhesives with robust tunable interfacial bonding strength is still its infancy stage. We herein identify a structurally novel supramolecular polymer scaffold, characterized by synergistic coexistence of hydrogen‐bonding (H−bonding) interactions electrostatic ionic junctions, endowing elastic remarkable...

A novel dextran-SG1 macro-alkoxyamine was designed to afford amphiphilic linear block copolymers synthesized by nitroxide mediated polymerization toward the formation of hierarchically structured bio-resourced honeycomb films.

Abstract Integrating self‐healing capability into supramolecular architectures is an interesting strategy, and can considerably enhance the performance broaden scope of applications for this important class polymers. Herein we report rational design novel V‐shaped barbiturate (Ba) functionalized soft–hard–soft triblock copolymers with a reversible healing motif in central part hard block, which undergoes autonomic repair at 30 °C. The designed synthesis also offers suitable macromolecular...

The facile preparation of novel supramolecular (ABAC)_n multiblock copolymers from Hamilton wedge and barbiturate functionalized H-bonding RAFT agents is reported.