A5053661157- Advanced Polymer Synthesis and Characterization
- Lipid Membrane Structure and Behavior
- Polymer Surface Interaction Studies
- Nanoparticle-Based Drug Delivery
- biodegradable polymer synthesis and properties
- Mass Spectrometry Techniques and Applications
- RNA Interference and Gene Delivery
- Advanced Drug Delivery Systems
- Surfactants and Colloidal Systems
- Nanocomposite Films for Food Packaging
- Nanoplatforms for cancer theranostics
- Supramolecular Chemistry and Complexes
- Hydrogels: synthesis, properties, applications
- Studies on Chitinases and Chitosanases
- Dendrimers and Hyperbranched Polymers
- Radioactive element chemistry and processing
- Chemical Synthesis and Analysis
- Electrostatics and Colloid Interactions
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Porphyrin and Phthalocyanine Chemistry
- Analytical Chemistry and Chromatography
- Carbon dioxide utilization in catalysis
- Nanopore and Nanochannel Transport Studies
- Advancements in Transdermal Drug Delivery
Université Claude Bernard Lyon 1
2016-2025
Centre National de la Recherche Scientifique
2015-2025
Université Jean Monnet
2022-2025
Institut National des Sciences Appliquées de Lyon
2015-2025
Ingenierie des Materiaux polymeres
2015-2024
École Polytechnique
2013
bioMérieux (France)
1998-2009
École Normale Supérieure de Lyon
1998-2008
École Nationale Supérieure de Chimie de Montpellier
2004-2008
Institut Charles Gerhardt Montpellier
2008
Poly(acrylic acid), PAA, was prepared by controlled radical polymerization with reversible addition−fragmentation chain transfer. Using trithiocarbonic acid dibenzyl ester, 1, and bis(1-phenylethyl) 2, as transfer agents (CTA), the is for low ratios [AA]:[CTA]. At higher ratios, plagued to solvent. Transfer polymer also detected at high conversion, shown presence of branches in NMR spectroscopy. In its neutralized form, PAA chains are not all terminated a thiol end group, elemental analysis,...
ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication the EditorNEXTControlled Radical Polymerization of Acrylic Acid in Protic MediaCatherine Ladavière, Nicole Dörr, and Jérôme P. ClaverieView Author Information LCPP CPE/CNRS 43, Bd 11 Novembre 1918, BP 2077, 69616 Villeurbanne Cedex, France Cite this: Macromolecules 2001, 34, 16, 5370–5372Publication Date (Web):June 28, 2001Publication History Received27 February 2001Revised30 May 2001Published online28 June inissue 1 July...
Dual systems combining Zn(C6F5)2 with an organic base (an amine or a phosphine) promote the controlled ring-opening polymerization of lactide and ε-caprolactone. The Lewis pairs cooperate to activate monomers, affording well-defined high molecular weight cyclic polyesters. Efficient chain-extension gives access block copolymers.
Biocompatible and biodegradable assemblies consisting of spherical particles coated with lipid layers were prepared from sub-micrometer poly(lactic acid) mixtures composed 1,2-dipalmitoyl-sn-glycero-3-phosphocholine 1,2-dipalmitoyl-3-trimethylammonium-propane. These original colloidal assemblies, named LipoParticles, are a great interest in biotechnology biomedicine. Nevertheless, major limitation their use is poor stability toward ionic strength. Indeed, electrostatic repulsions failed to...
The preparation of a homogeneous series chitin/chitosan oligomers (chito-oligomers) with the same distribution degrees polymerization (DP) ranging from 2 to 12, but various average N-acetylation (DA) 0 90% is described. This DA-series was obtained according two-step chemical process involving (i) production well-defined mixture glucosamine (GlcN) by acid hydrolysis fully N-deacetylated chitosan and after selective precipitations products, (ii) partial GlcN units these hydro-alcoholic...
Superparamagnetic iron oxide nanoparticles (SPIONs) have great potential for biomedical applications as multipurpose magnetic resonance imaging (MRI) contrast agents, and some systems already been approved by The United States Food Drug Administration clinical use. behavior, high saturation, fast synthesis are the major advantages of these nanomaterials. Polymer coatings often used to prevent cluster formation improve biocompatibility nanoparticles. In this work, we propose use chitosan (CS)...
Mass spectrometry techniques, specifically matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) and electrospray ionization (ESI-TOF) are of considerable interest for characterizing very attractive polymers resulting from controlled radical polymerizations (CRP). This work proposes a systematic experimental comparison both methods to analyze polystyrene prepared by five different CRP: nitroxide-mediated polymerization (mediated...
A matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI−TOF MS) study of N-acryloylmorpholine (NAM) homopolymers, as obtained by reversible addition−fragmentation chain transfer (RAFT) polymerization technique, is reported. Polymerization NAM was performed in dioxane using azobis(isobutyronitrile) (AIBN) initiator and tert-butyl dithiobenzoate RAFT agent. Polymer samples low molecular weights (<10 000 g mol-1) polydispersity indices (PDI < 1.1) were obtained,...
A model study was investigated to develop colloidal supramolecular assemblies consisting of particles coated with lipid layers. The interactions between monodisperse sulfate-charged poly(styrene) submicrometer and zwitterionic/cationic vesicles composed 1,2-dipalmitoyl-sn-glycero-3-phosphocholine 1,2-dipalmitoyl-3-trimethylammonium propane were considered. influence relevant experimental parameters on the final associations examined by quasi-elastic light scattering point out some new...
The existence of two mechanisms involved in the ultrasonically induced depolymerization chitosan is evidenced. first leads to a rapid scission polymer chains and lowering polydispersity, second responsible for obtaining short oligomers with polydispersity increase. A systematic experimental study allowed us identify quantify main parameters influencing chain kinetics. Consequently, using "master curve" approach, general law variation molecular weight during proposed. This can be used various...
The approval of two mRNA vaccines as urgent prophylactic treatments against Covid-19 made them a realistic alternative to conventional vaccination methods. However, naked is rapidly degraded by the body and cannot effectively penetrate cells. Vectors capable addressing these issues while allowing endosomal escape are therefore needed. To date, most widely used vectors for this purpose have been lipid-based vectors. Thus, we designed an innovative vector called LipoParticles (LP) consisting...
Abstract The hydrolysis of dihydrazides was studied at different pH values in water 25 °C. resulting species were analyzed by HPLC, 1 H‐NMR, and MALDI‐TOF mass spectrometry. Among these species, unexpected molecules bearing carboxylate moieties detected. Based on this analysis, a 2‐step mechanism proposed involving the formation cyclic linear intermediates before addition molecule to lead moieties. first step shown be rate‐determining catalyzed acidic conditions. To best our knowledge, study...
Abstract Low‐molecular‐weight poly(acrylic acid) (PAA) was synthesized by reversible addition fragmentation chain transfer polymerization with a trithiocarbonate as chain‐transfer agent (CTA). With combination of NMR spectroscopy and matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry, the PAA end‐groups polymer were analyzed before after neutralization sodium hydroxide. The prior to is made up expected chain‐ends H‐terminated chains issued from reaction solvent....
Supramolecular miktoarm stars (AB2 type) composed of poly (methyl methacrylate)-polystyrene2 (PMMA-PS2), poly(isoprene)-polystyrene2 (PI-PS2), and poly(vinyl acetate)-polystyrene2 (PVAc-PS2) were successfully synthesized by assembling reversible addition−fragmentation chain transfer (RAFT)-polymerized chains bearing hydrogen-bonding heterocomplementary associating units. To this end, thymine diaminopyridine-functionalized agents designed to efficiently mediate the polymerization vinyl...
We report an original strategy toward the straightforward preparation of precisely defined telechelic H-bonding polymers and generation supramolecular block copolymers thereof. Making use α,ω-functionalized symmetrical trithiocarbonate bearing thymine groups at both chain ends, a series heterocomplementary were effortlessly generated by RAFT polymerization in one step process. The resulting macromolecules selectively interacted with α-DAP-functionalized chains to afford solution bulk. These...
Intracellular pathogenic bacteria can lead to some of the most life-threatening infections. By evolving a number ingenious mechanisms, these have ability invade, colonize and survive in host cells active or latent forms over prolonged period time. A variety nanoparticulate systems been developed optimize delivery antibiotics. Main advantages as compared with free drugs are an efficient drug encapsulation, protection from inactivation, targeting infection sites possibility deliver by...
The radical telomerization of vinylidene fluoride (or 1,1-difluoroethylene, VDF) with iodotrifluoromethane initiated by tert-butyl peroxypivalate is presented. VDF telomers obtained were characterized 1H and 19F NMR spectroscopy matrix-assisted laser desorption−ionization time-of-flight mass spectrometry (MALDI TOF MS) that revealed low polydispersity indexes showing a pseudo-living character this reaction regarded as an iodine transfer polymerization process. CF3 CF2I end groups appear...