A5062258444- Memory and Neural Mechanisms
- Zebrafish Biomedical Research Applications
- Circadian rhythm and melatonin
- Alzheimer's disease research and treatments
- Microplastics and Plastic Pollution
- Financial Distress and Bankruptcy Prediction
- Effects and risks of endocrine disrupting chemicals
- Auditing, Earnings Management, Governance
- Neurological disorders and treatments
- Constraint Satisfaction and Optimization
- Geographic Information Systems Studies
- Inclusive Education and Diversity
- Atmospheric chemistry and aerosols
- Botulinum Toxin and Related Neurological Disorders
- Hereditary Neurological Disorders
- Odor and Emission Control Technologies
- Neuroscience and Neuropharmacology Research
- Neurological Disease Mechanisms and Treatments
- Polymer Science and PVC
- Air Quality Monitoring and Forecasting
- Semantic Web and Ontologies
- Stroke Rehabilitation and Recovery
- Taxation and Compliance Studies
University of Alabama at Birmingham Hospital
2025
University College London
2018-2024
McGill University
2016
Ipsen (United Kingdom)
2008
Background: Every minute is crucial in treating acute ischemic stroke (AIS), as the effectiveness of intravenous thrombolysis and endovascular therapy highly time-dependent. AHA/ASA guidelines recommend door-to-needle (DTN) times less than 60 minutes for at least 85% AIS patients treated with IV thrombolytics, further goals achieving DTN within 45 75% patients, 30 50% patients. However, a third meet these time frames, prompting implementation Launchpad protocol to hasten patient triage...
The regular firing pattern exhibited by medial entorhinal (mEC) grid cells of locomoting rodents is hypothesized to provide spatial metric information relevant for navigation. development virtual reality (VR) head-fixed mice confers a number experimental advantages and has become increasingly popular as method investigating spatially-selective cells. Recent experiments using 1D VR linear tracks have shown that some mEC multiple fields in space, analogous on real tracks. We recorded from the...
Therapeutic botulinum neurotoxin type A preparations have found an increasing number of clinical uses for a large variety neuromuscular disorders and dermatological conditions. The accurate determination potency in the application toxins is critical to ensuring efficacy safety, currently achieved by using lethal dose (LD50) assay mice. Ethical concerns operational constraints associated with this prompted development alternative systems that could potentially lead its replacement. As one...
Alzheimer's disease (AD) is characterised by progressive memory decline associated with hippocampal degeneration. However, the specific physiological mechanisms underlying dysfunction in AD remain poorly understood and improved knowledge may aid both diagnosis help identify new avenues for therapeutic intervention. We investigated how disruptions reactivations relate to place cell stability spatial deficits an mouse model. Using APP knock-in model 'NL-G-F', we conducted simultaneous...
Abstract The regular firing pattern exhibited by medial entorhinal (mEC) grid cells of locomoting rodents is hypothesized to provide spatial metric information relevant for navigation. development virtual reality (VR) head-fixed mice confers a number experimental advantages and has become increasingly popular as method investigating spatially-selective cells. Recent experiments using 1D VR linear tracks have shown that some mEC multiple fields in space, analogous on real tracks. We recorded...
We use Hidden Markov and Semi-Markov Models to study persistence of the compliance impact for tax examinations Employee Business Expense (EBE). Using panels yearly returns taxpayers reporting EBE, we compare future filing behavior those audited not audited, by fitting comp aring both groups. The state space is EBE compliance. observation vectors are a function reported line item amounts series annual filed starting two years after year audits, baseline year. functions used create proxies...